Linkage and association studies of the susceptibility genes for type 2 diabetes (Q36550050)

14 August 2017

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title

Linkage and association studies of the susceptibility genes for type 2 diabetes (English)

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14 August 2017

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Qing-Yang Huang

1

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PubMed ID

16875315

14 August 2017

Meng-Rong Cheng

series ordinal

2

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PubMed ID

16875315

14 August 2017

Sen-Lin Ji

series ordinal

3

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14 August 2017

1 July 2006

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Journal of Genetics and Genomics

14 August 2017

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14 August 2017

33

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14 August 2017

7

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14 August 2017

573-589

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Genetic factors in type 2 diabetes: the end of the beginning?

14 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24.

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Genome-wide and fine-mapping linkage studies of type 2 diabetes and glucose traits in the Old Order Amish: evidence for a new diabetes locus on chromosome 14q11 and confirmation of a locus on chromosome 1q21-q24.

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Genome-wide search for type 2 diabetes/impaired glucose homeostasis susceptibility genes in the Chinese: significant linkage to chromosome 6q21-q23 and chromosome 1q21-q24.

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Genome-wide Scan for Type 2 Diabetes Loci in Hong Kong Chinese and Confirmation of a Susceptibility Locus on Chromosome 1q21-q25

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A genome-wide scan for loci linked to plasma levels of glucose and HbA(1c) in a community-based sample of Caucasian pedigrees: The Framingham Offspring Study

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Liver pyruvate kinase polymorphisms are associated with type 2 diabetes in northern European Caucasians

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Mapping NIDDM Susceptibility Loci in French Families: Studies With Markers in the Region of NIDDM1 on Chromosome 2q

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A genome-wide search for type II diabetes susceptibility genes in Chinese Hans

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27.

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

SNP43 of CAPN10 and the risk of type 2 Diabetes in African-Americans: the Atherosclerosis Risk in Communities Study

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Haplotype combinations of calpain 10 gene polymorphisms associate with increased risk of impaired glucose tolerance and type 2 diabetes in South Indians

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Homozygous combination of calpain 10 gene haplotypes is associated with type 2 diabetes mellitus in a Polish population

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Variants in the calpain-10 gene predispose to insulin resistance and elevated free fatty acid levels

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A genomewide search for type 2 diabetes-susceptibility genes in indigenous Australians

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Genomewide search for type 2 diabetes susceptibility genes in four American populations

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: the Botnia study

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A Genome Scan for Type 2 Diabetes Susceptibility Loci in a Genetically Isolated Population

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Association between Ala54Thr substitution of the fatty acid-binding protein 2 gene with insulin resistance and intra-abdominal fat thickness in Japanese men.

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

FABP2 genotype is associated with insulin sensitivity in older women

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A major locus for fasting insulin concentrations and insulin resistance on chromosome 6q with strong pleiotropic effects on obesity-related phenotypes in nondiabetic Mexican Americans

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Novel susceptibility gene for late-onset NIDDM is localized to human chromosome 12q

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A Gene Conferring Susceptibility to Type 2 Diabetes in Conjunction With Obesity Is Located on Chromosome 18p11

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A Genome-Wide Search for Type 2 Diabetes Susceptibility Genes in West Africans: The Africa America Diabetes Mellitus (AADM) Study

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Evidence of a novel type 2 diabetes locus 50 cM centromeric to NIDDM2 on chromosome 12q.

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A genome-wide scan for type 2 diabetes in African-American families reveals evidence for a locus on chromosome 6q.

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Factors of insulin resistance syndrome--related phenotypes are linked to genetic locations on chromosomes 6 and 7 in nondiabetic mexican-americans

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Examination of candidate chromosomal regions for type 2 diabetes reveals a susceptibility locus on human chromosome 8p23.1.

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

The 3'-untranslated region polymorphism of the gene for skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in the type 2 diabetic Japanese population.

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Variation in the AU(AT)-Rich Element within the 3'-Untranslated Region of PPP1R3 Is Associated with Variation in Plasma Glucose in Aboriginal Canadians

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A genome-wide scan in type 2 diabetes mellitus provides independent replication of a susceptibility locus on 18p11 and suggests the existence of novel Loci on 2q12 and 19q13.

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A Genome-Wide Search for Genes Involved in Type 2 Diabetes in a Recently Genetically Isolated Population From the Netherlands

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Further evidence for a susceptibility locus for type 2 diabetes on chromosome 20q13.1-q13.2.

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi jewish population.

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Polymorphisms in both promoters of hepatocyte nuclear factor 4-alpha are associated with type 2 diabetes in the Amish

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Common Variants of the Hepatocyte Nuclear Factor-4 P2 Promoter Are Associated With Type 2 Diabetes in the U.K. Population

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Searching for osteoporosis genes in the post-genome era: progress and challenges

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Sib-pair linkage analysis for susceptibility genes for microvascular complications among Pima Indians with type 2 diabetes. Pima Diabetes Genes Group.

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: identification of a Pro12Ala PPAR gamma 2 missense mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: association with type 2 diabetes and trait differences.

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

The Pro12 -->Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53).

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Complex haplotypes of the PGC-1alpha gene are associated with carbohydrate metabolism and type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Association study designs for complex diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Exploring the dense mapping of a region of potential linkage in complex disease: an example in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

A Second-Stage Genome Scan for QTLs Influencing BMD Variation

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

High-resolution haplotype structure in the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21.

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Haplotype variation and linkage disequilibrium in 313 human genes

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Spotting the target: microarrays for disease gene discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

1 reference

7 January 2021

Multilocus linkage tests based on affected relative pairs.

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

Multi-center genetic study of hypertension: The Family Blood Pressure Program (FBPP).

1 reference

https://api.crossref.org/works/10.1016%2FS0379-4172%2806%2960087-5

7 January 2021

10.1016/S0379-4172(06)60087-5

Identifiers

DOI

1 reference

14 August 2017

1 reference

PubMed ID

16875315