Pharmacogenetics of uridine diphosphoglucuronosyltransferase (UGT) 1A family members and its role in patient response to irinotecan (Q36551126)

14 August 2017

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title

Pharmacogenetics of uridine diphosphoglucuronosyltransferase (UGT) 1A family members and its role in patient response to irinotecan (English)

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14 August 2017

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Swati Nagar

1

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14 August 2017

Rebecca L Blanchard

series ordinal

2

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14 August 2017

language of work or name

English

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publication date

1 January 2006

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14 August 2017

published in

Drug Metabolism Reviews

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14 August 2017

volume

38

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14 August 2017

issue

3

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14 August 2017

page(s)

393-409

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Genetic polymorphisms of the UDP-glucuronosyltransferase 1A7 gene and irinotecan toxicity in Japanese cancer patients

14 August 2017

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Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism?

21 January 2018

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The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome

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Genetic variation of human UDP-glucuronosyltransferase: implications in disease and drug glucuronidation

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Bilirubin mono- and di-glucuronide formation by purified rat liver microsomal bilirubin UDP-glucuronyltransferase

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Specificity of human UDP-glucuronosyltransferases and xenobiotic glucuronidation

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UDP-glucuronosyltransferases

21 January 2018

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Joint effects between UDP-glucuronosyltransferase 1A7 genotype and dietary carcinogen exposure on risk of colon cancer.

21 January 2018

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Irinotecan: a new antineoplastic agent for the management of colorectal cancer

21 January 2018

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Clinical pharmacokinetics of irinotecan

21 January 2018

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Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications

21 January 2018

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Evidence for overlapping active sites for 17 alpha-ethynlestradiol and bilirubin in the human major bilirubin UDPglucuronosyltransferase

21 January 2018

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Factors influencing the cellular accumulation of SN-38 and camptothecin

21 January 2018

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ABCG2 pharmacogenetics: ethnic differences in allele frequency and assessment of influence on irinotecan disposition

21 January 2018

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The importance of tumor glucuronidase in the activation of irinotecan in a mouse xenograft model.

21 January 2018

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Detection of UGT1A10 polymorphisms and their association with orolaryngeal carcinoma risk

21 January 2018

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Saccharic acid 1.4-lactone protects against CPT-11-induced mucosa damage in rats

21 January 2018

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Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38).

21 January 2018

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Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver.

21 January 2018

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Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus

21 January 2018

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Pharmacogenomics of human UDP-glucuronosyltransferase enzymes

21 January 2018

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Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene

21 January 2018

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Human liver UDP-glucuronosyltransferase isoforms involved in the glucuronidation of 7-ethyl-10-hydroxycamptothecin

21 January 2018

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Haplotypes of variants in the UDP-glucuronosyltransferase1A9 and 1A1 genes.

21 January 2018

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Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan

21 January 2018

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Irinotecan therapy in a 12-year-old girl with recurrent brain stem glioma and without functional polymorphisms in UGT1A1 activity: case report

21 January 2018

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UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity

21 January 2018

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Functional Characterization of Human UDP-Glucuronosyltransferase 1A9 Variant, D256N, Found in Japanese Cancer Patients

21 January 2018

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Functional Characterization of Wild-type and Variant (T202I and M59I) Human UDP-glucuronosyltransferase 1A10

21 January 2018

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Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38), an active metabolite of irinotecan (CPT-11), by human UGT1A1 variants, G71R, P229Q, and Y486D.

21 January 2018

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Genetic polymorphism in the phenobarbital-responsive enhancer module of the UDP-glucuronosyltransferase 1A1 gene and irinotecan toxicity

21 January 2018

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Frequent co-occurrence of the TATA box mutation associated with Gilbert’s syndrome (UGT1A1*28) with other polymorphisms of the UDP-glucuronosyltransferase-1 locus (UGT1A6*2 and UGT1A7*3) in Caucasians and Egyptians

21 January 2018

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Gilbert's syndrome is caused by a heterozygous missense mutation in the gene for bilirubin UDP-glucuronosyltransferase

21 January 2018

1 reference

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UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: I. Identification of polymorphisms in the 5'-regulatory and exon 1 regions, and association with human liver UGT1A6 gene expression and glucuronidation

21 January 2018

1 reference

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UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S).

21 January 2018

1 reference

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Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene

21 January 2018

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Lessons learned from the irinotecan metabolic pathway

21 January 2018

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Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism predicts the risk of gastrointestinal toxicity and fatigue induced by irinotecan-based chemotherapy.

21 January 2018

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Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer

21 January 2018

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Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells

21 January 2018

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Inhibition of beta-glucuronidase by natural glucuronides of kampo medicines using glucuronide of SN-38 (7-ethyl-10-hydroxycamptothecin) as a substrate.

21 January 2018

1 reference

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Influence of genetic variants in UGT1A1 and UGT1A9 on the in vivo glucuronidation of SN-38.

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530600739835

Combined polymorphisms in UDP-glucuronosyltransferases 1A1 and 1A6: implications for patients with Gilbert's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600739835

Relevance of different UGT1A1 polymorphisms in irinotecan-induced toxicity: a molecular and clinical study of 75 patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600739835

Three novel single nucleotide polymorphisms in UGT1A10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600739835

UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600739835

Phase I pharmacokinetic, food effect, and pharmacogenetic study of oral irinotecan given as semisolid matrix capsules in patients with solid tumors

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530600739835

Protective effects of kampo medicines and baicalin against intestinal toxicity of a new anticancer camptothecin derivative, irinotecan hydrochloride (CPT-11), in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600739835

Differential rates of glucuronidation for 7-ethyl-10-hydroxy-camptothecin (SN-38) lactone and carboxylate in human and rat microsomes and recombinant UDP-glucuronosyltransferase isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600739835

Endogenous substrates for UDP-glucuronosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600739835

Human UDP-glucuronosyltransferases: metabolism, expression, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600739835

Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600739835

Glucuronidation and the UDP-glucuronosyltransferases in health and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600739835

A novel polymorphism in the promoter region of human UGT1A9 gene (UGT1A9*22) and its effects on the transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600739835

Pharmacogenetic profiling across the irinotecan pathway in Asian patients with cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600739835

10.1080/03602530600739835

21 January 2018

Identifiers

DOI

1 reference

14 August 2017

1 reference