Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor (Q36555534)

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scientific article published on October 1995

Language	Label	Description	Also known as
English	Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor	scientific article published on October 1995

Statements

scholarly article

1 reference

Europe PubMed Central

14 August 2017

Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor (English)

1 reference

Europe PubMed Central

14 August 2017

cholecalciferol

1 reference

based on heuristic

inferred from title

Lynn P. Freedman

3

object named as

L P Freedman

1 reference

Europe PubMed Central

14 August 2017

author name string

I Alroy

1

1 reference

Europe PubMed Central

14 August 2017

T L Towers

2

1 reference

Europe PubMed Central

14 August 2017

language of work or name

0 references

publication date

1 October 1995

1 reference

Europe PubMed Central

14 August 2017

Molecular and Cellular Biology

1 reference

Europe PubMed Central

14 August 2017

15

1 reference

Europe PubMed Central

14 August 2017

5789-5799

1 reference

Europe PubMed Central

14 August 2017

10

1 reference

Europe PubMed Central

14 August 2017

Fos is a preferential target of glucocorticoid receptor inhibition of AP-1 activity in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

30 September 2017

The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

30 September 2017

Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

30 September 2017

Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene.

1 reference

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30 September 2017

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1 reference

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30 September 2017

Retinoid X receptors stimulate and 9-cis retinoic acid inhibits 1,25-dihydroxyvitamin D3-activated expression of the rat osteocalcin gene

1 reference

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30 September 2017

DNA target selectivity by the vitamin D3 receptor: mechanism of dimer binding to an asymmetric repeat element

1 reference

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30 September 2017

Analysis of the preexisting and nuclear forms of nuclear factor of activated T cells.

1 reference

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30 September 2017

Characterization of a negative retinoic acid response element in the murine Oct4 promoter

1 reference

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30 September 2017

Nuclear receptor/AP-1 interaction

1 reference

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30 September 2017

Isolation of the cyclosporin-sensitive T cell transcription factor NFATp

1 reference

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30 September 2017

NF-AT components define a family of transcription factors targeted in T-cell activation

1 reference

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Ligand modulates the conversion of DNA-bound vitamin D3 receptor (VDR) homodimers into VDR-retinoid X receptor heterodimers

1 reference

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30 September 2017

A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1.

1 reference

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30 September 2017

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1 reference

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30 September 2017

DNA sequences that act as high affinity targets for the vitamin D3 receptor in the absence of the retinoid X receptor.

1 reference

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30 September 2017

NF-AT-AP-1 and Rel-bZIP: hybrid vigor and binding under the influence

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30 September 2017

Influence of a steroid receptor DNA-binding domain on transcriptional regulatory functions

1 reference

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30 September 2017

The role of NFATp in cyclosporin A-sensitive tumor necrosis factor-alpha gene transcription

1 reference

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30 September 2017

Signal transmission between the plasma membrane and nucleus of T lymphocytes

1 reference

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30 September 2017

Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins

1 reference

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30 September 2017

NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus

1 reference

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30 September 2017

Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3

1 reference

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30 September 2017

T-cell growth factor: complete nucleotide sequence and organization of the gene in normal and malignant cells

1 reference

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30 September 2017

1 alpha,25-dihydroxyvitamin D3 induces maturation of the human monocyte cell line U937, and, in association with a factor from human T lymphocytes, augments production of the monokine, mononuclear cell factor

1 reference

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30 September 2017

Induction of monocytic differentiation and bone resorption by 1,25-dihydroxyvitamin D3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

30 September 2017

Inhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

30 September 2017

1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

30 September 2017

Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

30 September 2017

Characterization of antigen receptor response elements within the interleukin-2 enhancer

1 reference

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30 September 2017

A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

30 September 2017

The immunobiology of vitamin D.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

30 September 2017

Granulocyte-macrophage colony-stimulating factor. Sensitive and receptor-mediated regulation by 1,25-dihydroxyvitamin D3 in normal human peripheral blood lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

30 September 2017

Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3. Specific inhibition at the level of messenger RNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

30 September 2017

Cloning and expression of full-length cDNA encoding human vitamin D receptor

1 reference

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30 September 2017

Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation

1 reference

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Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1 reference

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Novel pathway for thyroid hormone receptor action through interaction with jun and fos oncogene activities

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30 September 2017

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

30 September 2017

Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

30 September 2017

Regulatory crosstalk at composite response elements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

30 September 2017

Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

30 September 2017

The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

30 September 2017

Cross-coupling of signal transduction pathways: zinc finger meets leucine zipper.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

30 September 2017

Vitamin D3 receptors: structure and function in transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

30 September 2017

Retinoic acid-induced down-regulation of the interleukin-2 promoter via cis-regulatory sequences containing an octamer motif

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

30 September 2017

The weak, fine-tuned binding of ubiquitous transcription factors to the II-2 enhancer contributes to its T cell-restricted activity

1 reference

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30 September 2017

DNA binding analysis of glucocorticoid receptor specificity mutants

1 reference

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30 September 2017

Vitamin D-mediated gene expression

1 reference

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30 September 2017

Interference of pathway specific transcription factors

1 reference

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30 September 2017

Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo

1 reference

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30 September 2017

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

1 reference

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Glucocorticoid-induced inhibition of T cell growth factor production. I. The effect on mitogen-induced lymphocyte proliferation

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30 September 2017

Transcriptional synergism between the vitamin D3 receptor and other nonreceptor transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

30 September 2017

Retinoic acid receptors and retinoid X receptor-alpha down-regulate the transforming growth factor-beta 1 promoter by antagonizing AP-1 activity

1 reference

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Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene

1 reference

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28 June 2018

1,25-Dihydroxyvitamin D3-regulated expression of genes involved in human T-lymphocyte proliferation and differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

28 June 2018

Regulation of human interleukin-2 gene: functional DNA sequences in the 5' flanking region for the gene expression in activated T lymphocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

28 June 2018

Mutations in the glucocorticoid receptor zinc finger region that distinguish interdigitated DNA binding and transcriptional enhancement activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

28 June 2018

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

1 reference

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28 June 2018

Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

28 June 2018

Ligand-activated thyroid hormone and retinoic acid receptors inhibit growth factor receptor promoter expression.

1 reference

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28 June 2018

Transcriptional regulation of the interleukin 2 gene by glucocorticoid hormones. Role of steroid receptor and antigen-responsive 5'-flanking sequences.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

28 June 2018

Transcription factor interactions: selectors of positive or negative regulation from a single DNA element.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

28 June 2018

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1 reference

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28 June 2018

Vitamin D receptor interaction with specific DNA. Association as a 1,25-dihydroxyvitamin D3-modulated heterodimer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

28 June 2018

Impairment of cytokine production in mice fed a vitamin D3-deficient diet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

28 June 2018

Nuclear factor of activated T cells contains Fos and Jun.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

28 June 2018

Functional interference between the ubiquitous and constitutive octamer transcription factor 1 (OTF-1) and the glucocorticoid receptor by direct protein-protein interaction involving the homeo subdomain of OTF-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

28 June 2018

The basic region of AP-1 specifies glucocorticoid receptor activity at a composite response element

1 reference

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28 June 2018

SPECIFIC HIGH-AFFINITY RECEPTORS FOR 1,25-DIHYDROXYVITAMIN D3IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS: PRESENCE IN MONOCYTES AND INDUCTION IN T LYMPHOCYTES FOLLOWING ACTIVATION

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230831

4 December 2018

T-cell activation. Transcriptional regulation in activated T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7565732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A similar DNA-binding motif in NFAT family proteins and the Rel homology region

1 reference

https://pubmed.ncbi.nlm.nih.gov/7565732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lymphokine regulation of activated (G1) lymphocytes. II. Glucocorticoid and anti-Tac-induced inhibition of human T lymphocyte proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7565732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1,25-dihydroxyvitamin D3: a novel immunoregulatory hormone

1 reference

https://pubmed.ncbi.nlm.nih.gov/7565732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1,25-Dihydroxyvitamin D3 inhibits antigen-induced T cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7565732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1,25-Dihydroxyvitamin D3 suppresses human T helper/inducer lymphocyte activity in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/7565732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of 1,25-dihydroxyvitamin D3 on human T lymphocyte activation and proliferation: a cell cycle analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/7565732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of 1,25-dihydroxyvitamin D3 on human lymphocytes and monocyte/macrophages: inhibition of interleukin-2 and augmentation of interleukin-1 production

1 reference

https://pubmed.ncbi.nlm.nih.gov/7565732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Negative regulation by glucocorticoids through interference with a cAMP responsive enhancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/7565732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of alpha-fetoprotein gene expression by antagonism between AP-1 and the glucocorticoid receptor at their overlapping binding site

1 reference

https://pubmed.ncbi.nlm.nih.gov/7565732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A T cell nuclear factor resembling NF-AT binds to an NF-kappa B site and to the conserved lymphokine promoter sequence “cytokine-1”

1 reference

https://pubmed.ncbi.nlm.nih.gov/7565732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA Binding Properties of the Vitamin D3Receptor Zinc Finger Region

1 reference

https://pubmed.ncbi.nlm.nih.gov/7565732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/7565732

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.15.10.5789

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

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