Exploiting our knowledge of NF-kappaB signaling for the treatment of mammary cancer (Q36561723)

14 August 2017

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title

Exploiting our knowledge of NF-kappaB signaling for the treatment of mammary cancer (English)

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14 August 2017

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Michael C Haffner

1

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PubMed ID

16900390

14 August 2017

Chiara Berlato

series ordinal

2

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PubMed ID

16900390

14 August 2017

Wolfgang Doppler

series ordinal

3

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14 August 2017

1 January 2006

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Journal of Mammary Gland Biology and Neoplasia

14 August 2017

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14 August 2017

11

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14 August 2017

1

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14 August 2017

63-73

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https://scigraph.springernature.com/pub.10.1007/s10911-006-9013-5

14 August 2017

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Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation

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A role for NF-kappa B activation in perforin expression of NK cells upon IL-2 receptor signaling

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Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK.

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Selective recognition of the activated form of transcription factor NF-kappa B by a monoclonal antibody

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TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway

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12 December 2020

COX-2 inhibitors for the prevention of breast cancer

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12 December 2020

IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy

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12 December 2020

Perturbation of beta1-integrin function in involuting mammary gland results in premature dedifferentiation of secretory epithelial cells

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A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation).

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The role of prolactin in mammary carcinoma

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In vivo transfection of cis element "decoy" against nuclear factor-kappaB binding site prevents myocardial infarction

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12 December 2020

Apoptosis induction by a novel retinoid-related molecule requires nuclear factor-kappaB activation.

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Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

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Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs

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Role of NF-κB in p53-mediated programmed cell death

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12 December 2020

Both N- and C-terminal domains of parathyroid hormone-related protein increase interleukin-6 by nuclear factor-kappa B activation in osteoblastic cells.

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Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.

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12 December 2020

The clinical significance between activation of nuclear factor kappa B transcription factor and overexpression of HER-2/neu oncoprotein in Taiwanese patients with breast cancer

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Chemoprevention: an essential approach to controlling cancer

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12 December 2020

HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway

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12 December 2020

Mechanisms of bone metastasis

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12 December 2020

NF-kappaB activity in transgenic mice: developmental regulation and tissue specificity.

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12 December 2020

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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12 December 2020

NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4

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12 December 2020

Estrogen withdrawal-induced NF-kappaB activity and bcl-3 expression in breast cancer cells: roles in growth and hormone independence

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12 December 2020

Rapamycin inhibits proteasome activator expression and proteasome activity

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12 December 2020

Anticancer agent CHS 828 suppresses nuclear factor-kappa B activity in cancer cells through downregulation of IKK activity

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12 December 2020

Revisiting immunosurveillance and immunostimulation: Implications for cancer immunotherapy

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12 December 2020

NF-kappaB inhibits apoptosis in murine mammary epithelia

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Inhibition of NFkappaB increases the efficacy of cisplatin in in vitro and in vivo ovarian cancer models

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Loss of nuclear factor-kappaB is tumor promoting but does not substitute for loss of p53.

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Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice

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Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase.

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12 December 2020

Activation of NF-kappaB/Rel occurs early during neoplastic transformation of mammary cells

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12 December 2020

Selective activation of NF-kappa B subunits in human breast cancer: potential roles for NF-kappa B2/p52 and for Bcl-3

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12 December 2020

A Phase I study of CHS 828 in patients with solid tumor malignancy

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12 December 2020

IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

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12 December 2020

Host microenvironment in breast cancer development: inflammatory cells, cytokines and chemokines in breast cancer progression: reciprocal tumor-microenvironment interactions

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12 December 2020

The sesquiterpene lactone parthenolide in combination with docetaxel reduces metastasis and improves survival in a xenograft model of breast cancer.

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12 December 2020

Apoptosis caused by chemotherapeutic inhibition of nuclear factor-kappaB activation

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12 December 2020

The proteasome: a suitable antineoplastic target

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12 December 2020

NF-kappaB regulation in the immune system

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12 December 2020

NF-kappaB as a therapeutic target in cancer

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12 December 2020

ERBB receptors and cancer: the complexity of targeted inhibitors

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12 December 2020

Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer.

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12 December 2020

Targeting of nuclear factor kappaB Pathways by dehydroxymethylepoxyquinomicin, a novel inhibitor of breast carcinomas: antitumor and antiangiogenic potential in vivo.

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12 December 2020

NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia

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12 December 2020

NF-kappaB in cancer--a friend turned foe.

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12 December 2020

Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]

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12 December 2020

NF-kappaB in mammary gland development and breast cancer

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12 December 2020

The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase

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12 December 2020

The role of the ubiquitination-proteasome pathway in breast cancer: applying drugs that affect the ubiquitin-proteasome pathway to the therapy of breast cancer

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12 December 2020

Nuclear localisation of nuclear factor-kappaB transcription factors in prostate cancer: an immunohistochemical study

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12 December 2020

Inducible IkappaB kinase/IkappaB kinase epsilon expression is induced by CK2 and promotes aberrant nuclear factor-kappaB activation in breast cancer cells

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12 December 2020

Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cells

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12 December 2020

Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex

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12 December 2020

Thalidomide in cancer medicine

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12 December 2020

Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence

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12 December 2020

Tumour-educated macrophages promote tumour progression and metastasis

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12 December 2020

Inhibition of tumor necrosis factor-alpha -induced nuclear translocation and activation of NF-kappa B by dehydroxymethylepoxyquinomicin

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12 December 2020

Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cells

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12 December 2020

Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone

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12 December 2020

Treatment of advanced breast cancer: the good, the bad and the ugly

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12 December 2020

Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks

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12 December 2020

Selective inhibition of NF-?B in dendritic cells by the NEMO-binding domain peptide blocks maturation and prevents T cell proliferation and polarization

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12 December 2020

Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer

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12 December 2020

Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells

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12 December 2020

Shaping the nuclear action of NF-kappaB

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12 December 2020

Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex

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12 December 2020

Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors

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12 December 2020

The three Es of cancer immunoediting

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12 December 2020

Activation of NF-kappaB p50/p65 is regulated in the developing mammary gland and inhibits STAT5-mediated beta-casein gene expression

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12 December 2020

Insulin-like growth factors and neoplasia.

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12 December 2020

Expression of ErbB2 enhances radiation-induced NF-kappaB activation

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12 December 2020

Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity

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12 December 2020

Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB

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12 December 2020

The IKK NF-kappa B system: a treasure trove for drug development

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12 December 2020

The replacement of ATP by the competitive inhibitor emodin induces conformational modifications in the catalytic site of protein kinase CK2

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12 December 2020

Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.

1 reference

12 December 2020

Missing pieces in the NF-kappaB puzzle

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12 December 2020

The Role of c-erbB-2 as a predictive factor in breast cancer

1 reference

12 December 2020

10.1007/S10911-006-9013-5

Identifiers

DOI

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14 August 2017

1 reference

PubMed ID

16900390