The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush (Q36567796)

15 August 2017

The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush (English)

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15 August 2017

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3

Eckhard Mandelkow

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15 August 2017

Daniel J Müller

4

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author name string

Susanne Wegmann

series ordinal

1

1 reference

15 August 2017

Izhar D Medalsy

series ordinal

2

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15 August 2017

language of work or name

English

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publication date

26 December 2012

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Proceedings of the National Academy of Sciences of the United States of America

15 August 2017

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15 August 2017

110

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15 August 2017

4

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15 August 2017

E313-21

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describes a project that uses

15 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3557036/fullTextXML

inferred from PubMed Central ID database lookup

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Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability

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A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

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Complementary dimerization of microtubule-associated tau protein: Implications for microtubule bundling and tau-mediated pathogenesis

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Structure of core domain of fibril-forming PHF/Tau fragments.

30 September 2017

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The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which tau mediates beta-amyloid-induced neurodegeneration.

30 September 2017

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The role of caspase cleavage of tau in Alzheimer disease neuropathology

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Tau aggregation is driven by a transition from random coil to beta sheet structure

30 September 2017

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Tau paired helical filaments from Alzheimer's disease brain and assembled in vitro are based on beta-structure in the core domain

30 September 2017

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Tau filaments from human brain and from in vitro assembly of recombinant protein show cross-beta structure

30 September 2017

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Predicting properties of intrinsically unstructured proteins

30 September 2017

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The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease

30 September 2017

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Structure of the alpha beta tubulin dimer by electron crystallography

30 September 2017

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MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

30 September 2017

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Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

30 September 2017

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Tau protein function in living cells

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Structural characterization of the core of the paired helical filament of Alzheimer disease

30 September 2017

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Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles.

30 September 2017

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Microtubule bundling by tau proteins in vivo: analysis of functional domains

30 September 2017

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Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin

30 September 2017

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Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

30 September 2017

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Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution

30 September 2017

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28 June 2018

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Structural stability of paired helical filaments requires microtubule-binding domains of Tau: A model for self-association

28 June 2018

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Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons

28 June 2018

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β-Sheet core of tau paired helical filaments revealed by solid-state NMR.

28 June 2018

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Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model

21 September 2018

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Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment

21 September 2018

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The core of tau-paired helical filaments studied by scanning transmission electron microscopy and limited proteolysis

21 September 2018

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Regions of tau implicated in the paired helical fragment core as defined by NMR.

21 September 2018

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Purification of recombinant tau protein and preparation of Alzheimer-paired helical filaments in vitro.

21 September 2018

1 reference

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Site-specific nitration and oxidative dityrosine bridging of the tau protein by peroxynitrite: implications for Alzheimer's disease

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557036

Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557036

On the rigidity of the cytoskeleton: are MAPs crosslinkers or spacers of microtubules?

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557036

Imaging and Quantifying Chemical and Physical Properties of Native Proteins at Molecular Resolution by Force-Volume AFM

21 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1212100110

Modulation of repulsive forces between neurofilaments by sidearm phosphorylation

21 January 2018

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12 December 2020

Molecular flexibility in microtubule proteins: proton nuclear magnetic resonance characterization

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12 December 2020

Domains of tau protein and interactions with microtubules

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12 December 2020

Entropic exclusion by neurofilament sidearms: a mechanism for maintaining interfilament spacing

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12 December 2020

The dynamic structure of filamentous tau

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1212100110

1 reference

15 August 2017

0 references

1 reference

15 August 2017

PubMed publication ID

23269837

1 reference