Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein. (Q36569418)

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22 February 2020

title

Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein (English)

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22 February 2020

5

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22 February 2020

6

Marie K Mankowski

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22 February 2020

7

Roger G Ptak

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22 February 2020

author name string

Isaac Zentner

1

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22 February 2020

Luz-Jeannette Sierra

2

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22 February 2020

Lina Maciunas

3

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22 February 2020

Andrei Vinnik

4

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22 February 2020

Julio Martín-García

8

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22 February 2020

Simon Cocklin

9

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22 February 2020

language of work or name

English

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publication date

29 November 2012

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Bioorganic & Medicinal Chemistry Letters

22 February 2020

published in

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volume

23

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22 February 2020

issue

4

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22 February 2020

page(s)

1132-1135

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Transcription Factor DLX5 As a New Target for Promising Antitumor Agents

22 February 2020

cites work

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Inhibiting early-stage events in HIV-1 replication by small-molecule targeting of the HIV-1 capsid

30 September 2017

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Structure-based drug design of a new chemical class of small molecules active against influenza A nucleoprotein in vitro and in vivo

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Application of a novel in silico high-throughput screen to identify selective inhibitors for protein-protein interactions

30 September 2017

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HIV-1 matrix organizes as a hexamer of trimers on membranes containing phosphatidylinositol-(4,5)-bisphosphate

30 September 2017

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Interaction between the human immunodeficiency virus type 1 Gag matrix domain and phosphatidylinositol-(4,5)-bisphosphate is essential for efficient gag membrane binding

30 September 2017

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Point Mutations in the HIV-1 Matrix Protein Turn Off the Myristyl Switch

30 September 2017

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Human immunodeficiency virus type 1 matrix protein assembles on membranes as a hexamer

30 September 2017

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30 September 2017

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Structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly.

30 September 2017

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Interactions of HIV-1 Gag with assembly cofactors

30 September 2017

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Oxadiazols: a new class of rationally designed anti-human immunodeficiency virus compounds targeting the nuclear localization signal of the viral matrix protein

30 September 2017

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Protein production by auto-induction in high density shaking cultures

30 September 2017

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Biologic and genetic characterization of a panel of 60 human immunodeficiency virus type 1 isolates, representing clades A, B, C, D, CRF01_AE, and CRF02_AG, for the development and assessment of candidate vaccines

30 September 2017

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Phosphatidylinositol (4,5) bisphosphate regulates HIV-1 Gag targeting to the plasma membrane

30 September 2017

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Drug-like annotation and duplicate analysis of a 23-supplier chemical database totalling 2.7 million compounds

30 September 2017

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Cell-type-dependent targeting of human immunodeficiency virus type 1 assembly to the plasma membrane and the multivesicular body

30 September 2017

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A myristoyl switch regulates membrane binding of HIV-1 Gag.

30 September 2017

1 reference

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Entropic switch regulates myristate exposure in the HIV-1 matrix protein

30 September 2017

1 reference

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Localization of human immunodeficiency virus type 1 Gag and Env at the plasma membrane by confocal imaging

30 September 2017

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Molecular modelling study of HIV p17gag (MA) protein shell utilising data from electron microscopy and X-ray crystallography

30 September 2017

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Use of calibrated viral load standards for group M subtypes of human immunodeficiency virus type 1 to assess the performance of viral RNA quantitation tests

30 September 2017

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Role of the Gag matrix domain in targeting human immunodeficiency virus type 1 assembly

30 September 2017

1 reference

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Development of calibrated viral load standards for group M subtypes of human immunodeficiency virus type 1 and performance of an improved AMPLICOR HIV-1 MONITOR test with isolates of diverse subtypes

30 September 2017

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Performance of the Affymetrix GeneChip HIV PRT 440 platform for antiretroviral drug resistance genotyping of human immunodeficiency virus type 1 clades and viral isolates with length polymorphisms

30 September 2017

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Binding of human immunodeficiency virus type 1 Gag to membrane: role of the matrix amino terminus.

30 September 2017

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Opposing effects of human immunodeficiency virus type 1 matrix mutations support a myristyl switch model of gag membrane targeting.

30 September 2017

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Human immunodeficiency virus type 1 protease triggers a myristoyl switch that modulates membrane binding of Pr55(gag) and p17MA.

30 September 2017

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Membrane binding of human immunodeficiency virus type 1 matrix protein in vivo supports a conformational myristyl switch mechanism

30 September 2017

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Differential membrane binding of the human immunodeficiency virus type 1 matrix protein

30 September 2017

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Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: implications for membrane association and assembly

30 September 2017

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Mutations in the N-terminal region of human immunodeficiency virus type 1 matrix protein block intracellular transport of the Gag precursor

30 September 2017

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Identification of a membrane-binding domain within the amino-terminal region of human immunodeficiency virus type 1 Gag protein which interacts with acidic phospholipids

30 September 2017

1 reference

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Single amino acid changes in the human immunodeficiency virus type 1 matrix protein block virus particle production

30 September 2017

1 reference

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Three-dimensional structure of the human immunodeficiency virus type 1 matrix protein

30 September 2017

1 reference

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Subgroup G HIV type 1 isolates from Nigeria

30 September 2017

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Genetic variation of HIV type 1 in four World Health Organization-sponsored vaccine evaluation sites: generation of functional envelope (glycoprotein 160) clones representative of sequence subtypes A, B, C, and E. WHO Network for HIV Isolation and C

30 September 2017

1 reference

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Variability of human immunodeficiency virus type 1 group O strains isolated from Cameroonian patients living in France

30 September 2017

1 reference

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Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1

30 September 2017

1 reference

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Myristoylation-dependent replication and assembly of human immunodeficiency virus 1

30 September 2017

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Basic local alignment search tool

30 September 2017

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Highly drug-resistant HIV-1 clinical isolates are cross-resistant to many antiretroviral compounds in current clinical development

30 September 2017

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Further evidence for hexagonal organization of HIV gag protein in prebudding assemblies and immature virus-like particles.

28 June 2018

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Fullerene-like organization of HIV gag-protein shell in virus-like particles produced by recombinant baculovirus

28 June 2018

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Characterization of an HIV-1 Isolate Displaying an Apparent Absence of Virion-Associated Reverse Transcriptase Activity

28 June 2018

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O(NlogN) continuous electrostatics method for fast calculation of solvation energies of biomolecules.

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HaloTag: a novel protein labeling technology for cell imaging and protein analysis

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Ligation independent cloning vectors for expression of SUMO fusions

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Assembly of human immunodeficiency virus precursor gag proteins

21 September 2018

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Antiviral inhibition of the HIV-1 capsid protein

21 September 2018

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21 September 2018

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Molecular dynamics analysis of HIV-1 matrix protein: clarifying differences between crystallographic and solution structures

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12 December 2020

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Comparison of methods for immobilization to carboxymethyl dextran sensor surfaces by analysis of the specific activity of monoclonal antibodies

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Implications for viral capsid assembly from crystal structures of HIV-1 Gag(1-278) and CA(N)(133-278)

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12 December 2020

10.1016/J.BMCL.2012.11.041

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release_bbr4llplj5ckvbf6bcm5svi6mq

22 February 2020

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22 February 2020

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