Role of the aryl hydrocarbon receptor in drug metabolism (Q36572621)

15 August 2017

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title

Role of the aryl hydrocarbon receptor in drug metabolism (English)

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15 August 2017

Preeti Ramadoss

1

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15 August 2017

Craig Marcus

series ordinal

2

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15 August 2017

Gary H Perdew

series ordinal

3

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15 August 2017

language of work or name

English

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publication date

1 June 2005

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Expert Opinion on Drug Metabolism & Toxicology

15 August 2017

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15 August 2017

1

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15 August 2017

9-21

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15 August 2017

1

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Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin

15 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Aryl hydrocarbon receptor response to indigoids in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Aryl hydrocarbon receptor-mediated induction of microsomal drug-metabolizing enzyme activity by indirubin and indigo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Aspartate aminotransferase generates proagonists of the aryl hydrocarbon receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Role of the aryl hydrocarbon receptor in the development of control and 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed male mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Aryl hydrocarbon receptor-deficient mice generate normal immune responses to model antigens and are resistant to TCDD-induced immune suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Long-term hazards of polychlorinated dibenzodioxins and polychlorinated dibenzofurans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

The role of chaperone proteins in the aryl hydrocarbon receptor core complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Nuclear localization and export signals of the human aryl hydrocarbon receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Nucleocytoplasmic shuttling of the aryl hydrocarbon receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Subcellular localization of the aryl hydrocarbon receptor is modulated by the immunophilin homolog hepatitis B virus X-associated protein 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Analysis of the complex relationship between nuclear export and aryl hydrocarbon receptor-mediated gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

p27(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

A novel induction mechanism of the rat CYP1A2 gene mediated by Ah receptor-Arnt heterodimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Dioxin-responsive AHRE-II gene battery: identification by phylogenetic footprinting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

2,3,7,8-Tetrachlorodibenzo-p-dioxin blocks androgen-dependent cell proliferation of LNCaP cells through modulation of pRB phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Role of the aryl hydrocarbon receptor in cell cycle regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

The RelA NF-kappaB subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

The choice of proton pump inhibitor: does it matter?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Signal transduction-mediated activation of the aryl hydrocarbon receptor in rat hepatoma H4IIE cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Regulation of dioxin receptor function by omeprazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Use of 2-azido-3-[125I]iodo-7,8-dibromodibenzo-p-dioxin as a probe to determine the relative ligand affinity of human versus mouse aryl hydrocarbon receptor in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Different structural requirements of the ligand binding domain of the aryl hydrocarbon receptor for high- and low-affinity ligand binding and receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Differences in inducibility of CYP1A1-mRNA by benzimidazole compounds between human and mouse cells: evidences of a human-specific signal transduction pathway for CYP1A1 induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Methyl-substituted diindolylmethanes as inhibitors of estrogen-induced growth of T47D cells and mammary tumors in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Indole-3-carbinol and 3,3′-diindolylmethane induce apoptosis in human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Indole-3-carbinol induces a G1 cell cycle arrest and inhibits prostate-specific antigen production in human LNCaP prostate carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Analysis of the antiestrogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in human ovarian carcinoma BG-1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Identification of a motif within the 5' regulatory region of pS2 which is responsible for AP-1 binding and TCDD-mediated suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Modulation of oestrogen receptor signalling by association with the activated dioxin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Polymorphisms in the human AH receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Human aryl hydrocarbon receptor polymorphisms that result in loss of CYP1A1 induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Divergent roles of hepatitis B virus X-associated protein 2 (XAP2) in human versus mouse Ah receptor complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Comparative analysis of dioxin response elements in human, mouse and rat genomic sequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Pharmacogenetics of the major polymorphic metabolizing enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

The drug salicylamide is an antagonist of the aryl hydrocarbon receptor that inhibits signal transduction induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Regulation, function, and tissue-specific expression of cytochrome P450 CYP1B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Unraveling gene-gene interactions regulated by ligands of the aryl hydrocarbon receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Polymorphisms of the CYP1B1 gene have higher risk for prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Expression of CYP1B1 in human adult and fetal tissues and differential inducibility of CYP1B1 and CYP1A1 by Ah receptor ligands in human placenta and cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Human CYP1B1 is regulated by estradiol via estrogen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Role of the aryl hydrocarbon receptor and Cyp1b1 in the antiestrogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Modification of ocular defects in mouse developmental glaucoma models by tyrosinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Pharmacogenetics of the cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Human drug metabolising cytochrome P450 enzymes: properties and polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Functional analysis of six different polymorphic CYP1B1 enzyme variants found in an Ethiopian population

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Impact of Agent Orange exposure among Korean Vietnam veterans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Transcript profiling of enzymes involved in detoxification of xenobiotics and reactive oxygen in human normal and simian virus 40 T antigen-immortalized oral keratinocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Polymorphisms in the CYP1B1 gene are associated with increased risk of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

CYP1B1 expression in prostate is higher in the peripheral than in the transition zone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Docetaxel (Taxotere) is not metabolized by recombinant human CYP1B1 in vitro, but acts as an effector of this isozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Cytochrome P450 CYP1B1 protein expression: a novel mechanism of anticancer drug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Discovery of cytochrome P450 1B1 inhibitors as new promising anti-cancer agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Functional significance of a C-->A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Identification of a novel dioxin-inducible cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Identification of genetic polymorphisms of CYP2S1 in a Finnish Caucasian population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.9

21 January 2018

Identifiers

DOI

10.1517/17425255.1.1.9

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15 August 2017

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