Mechanisms of disease: Pathway-selective insulin resistance and microvascular complications of diabetes (Q36575450)

15 August 2017

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title

Mechanisms of disease: Pathway-selective insulin resistance and microvascular complications of diabetes (English)

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15 August 2017

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Per-Henrik Groop

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15 August 2017

2

Carol Forsblom

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15 August 2017

Merlin C Thomas

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15 August 2017

1 December 2005

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Nature Clinical Practice Endocrinology and Metabolism

15 August 2017

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15 August 2017

1

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15 August 2017

100-110

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15 August 2017

2

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Global prevalence of diabetes: estimates for the year 2000 and projections for 2030

15 August 2017

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https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Effects of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Peroxisome proliferator-activated receptor family and its relationship to renal complications of the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Normal valine disposal in obese subjects with impaired glucose disposal: evidence for selective insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Metabolic consequences of hyperinsulinaemia imposed on normal rats on glucose handling by white adipose tissue, muscles and liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Insulin resistance, hypertension and microalbuminuria in patients with type 2 (non-insulin-dependent) diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Type 2 diabetes: principles of pathogenesis and therapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Cellular mechanisms of insulin resistance

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Defective nitric oxide synthesis: a link between metabolic insulin resistance, sympathetic overactivity and cardiovascular morbidity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Insulin stimulates both endothelin and nitric oxide activity in the human forearm.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Activation of the endothelin system in insulin resistance.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Microvascular function in human diabetes. A physiological perspective

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Metabolic syndrome and hypertension: pathophysiology and molecular basis of insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Metabolic syndrome in type 1 diabetes: association with diabetic nephropathy and glycemic control (the FinnDiane study).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Insulin resistance and endothelial dysfunction in type 2 diabetes patients with or without microalbuminuria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Insulin action and skeletal muscle blood flow in patients with Type 1 diabetes and microalbuminuria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Increased urinary albumin excretion, insulin resistance, and related cardiovascular risk factors in patients with type 2 diabetes: evidence of a sex-specific association

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Increased transcapillary escape rate of albumin in nondiabetic men in response to hyperinsulinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Differential Regulation of Early Growth Response Gene-1 Expression by Insulin and Glucose in Vascular Endothelial Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Markers of insulin resistance are strong risk factors for retinopathy incidence in type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Insulin resistance and proliferative retinopathy: a cross-sectional, case-control study in 115 patients with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Different patterns of insulin resistance in relatives of type 1 diabetic patients with retinopathy or nephropathy: the Genesis France-Belgium Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Plasma glucose and prediction of microvascular disease and mortality: evaluation of 1997 American Diabetes Association and 1999 World Health Organization criteria for diagnosis of diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Insulin activates vascular endothelial growth factor in vascular smooth muscle cells: influence of nitric oxide and of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Insulin resistance. Does it play a role in peripheral neuropathy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

The spectrum of neuropathy in diabetes and impaired glucose tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Endoneurial capillary abnormalities presage deterioration of glucose tolerance and accompany peripheral neuropathy in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Peripheral neuropathy and microangiopathy in rats with insulinoma: association with chronic hyperinsulinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Direct insulin signaling of neurons reverses diabetic neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Insulin enhances mitochondrial inner membrane potential and increases ATP levels through phosphoinositide 3-kinase in adult sensory neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Opposing extracellular signal-regulated kinase and Akt pathways control Schwann cell myelination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Effect of sodium intake on blood pressure and albuminuria in Type 2 diabetic patients: the role of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Hemodynamic and renal responses to chronic hyperinsulinemia in obese, insulin-resistant dogs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Insulin's acute effects on glomerular filtration rate correlate with insulin sensitivity whereas insulin's acute effects on proximal tubular sodium reabsorption correlation with salt sensitivity in normal subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Insulin inhibits dexamethasone effect on angiotensinogen gene expression and induction of hypertrophy in rat kidney proximal tubular cells in high glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Biochemistry and molecular cell biology of diabetic complications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Improved insulin sensitivity is associated with restricted intake of dietary glycoxidation products in the db/db mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Evidence that pioglitazone, metformin and pentoxifylline are inhibitors of glycation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

A nutrient-sensing pathway regulates leptin gene expression in muscle and fat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Role of hexosamines in insulin resistance and nutrient sensing in human adipose and muscle tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Aldose reductase inhibitor improves insulin-mediated glucose uptake and prevents migration of human coronary artery smooth muscle cells induced by high glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Partial gene deletion of endothelial nitric oxide synthase predisposes to exaggerated high-fat diet-induced insulin resistance and arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Polycystic ovary syndrome is associated with endothelial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Fetal growth and glucose and insulin metabolism in four-year-old Indian children

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Birth weight is inversely correlated to adult systolic blood pressure and pulse pressure in type 1 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Insulin action during acute starvation: Evidence for selective insulin resistance in normal man

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Insulin resistance of puberty: a defect restricted to peripheral glucose metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

Insulin action is associated with endothelial function in hypertension and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

7 January 2021

Insulin resistance precedes microalbuminuria in patients with insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

7 January 2021

Effects of insulin on renal haemodynamics and sodium handling in normal subjects

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

7 January 2021

Insulin resistance, elevated glomerular filtration fraction, and renal injury

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

7 January 2021

High expression of PKC-MAPK pathway mRNAs correlates with glomerular lesions in human diabetic nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

7 January 2021

Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

7 January 2021

Arterio-venous shunting and proliferating new vessels in acute painful neuropathy of rapid glycaemic control (insulin neuritis)

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

7 January 2021

Insulin resistance in essential hypertension

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

7 January 2021

Renal handling of urate and sodium during acute physiological hyperinsulinaemia in healthy subjects

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

7 January 2021

The renal response to exogenous insulin in non-insulin-dependent diabetes mellitus in relation to blood pressure and cardiovascular hormonal status

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

7 January 2021

Acute reversal of lipid-induced muscle insulin resistance is associated with rapid alteration in PKC-theta localization

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

7 January 2021

Risk of advanced diabetic nephropathy in type 1 diabetes is associated with endothelial nitric oxide synthase gene polymorphism

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0046

7 January 2021

Identifiers

DOI

10.1038/NCPENDMET0046

1 reference

15 August 2017

1 reference

PubMed ID

16929378