Expression of adenoviral E3 transgenes in beta cells prevents autoimmune diabetes (Q36575556)

15 August 2017

Expression of adenoviral E3 transgenes in beta cells prevents autoimmune diabetes (English)

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15 August 2017

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S Efrat

2

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author name string

M G von Herrath

series ordinal

1

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15 August 2017

M B Oldstone

series ordinal

3

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15 August 2017

M S Horwitz

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4

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15 August 2017

language of work or name

English

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publication date

1 September 1997

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Proceedings of the National Academy of Sciences of the United States of America

15 August 2017

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15 August 2017

94

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15 August 2017

18

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15 August 2017

9808-9813

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Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression

15 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23273

Interferon-gamma is essential for destruction of beta cells and development of insulin-dependent diabetes mellitus

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23273

Adenoviruses as gene-delivery vehicles

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23273

CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23273

Adenovirus genes that modulate the sensitivity of virus-infected cells to lysis by TNF.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23273

MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23273

Focal expression of interleukin-2 does not break unresponsiveness to "self" (viral) antigen expressed in beta cells but enhances development of autoimmune disease (diabetes) after initiation of an anti-self immune response

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23273

Virus and cytotoxic T lymphocytes: crucial role of viral peptide secondary structure in major histocompatibility complex class I interactions

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23273

Prolonged survival of pancreatic islet allografts mediated by adenovirus immunoregulatory transgenes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23273

E3 transcription unit of adenovirus

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23273

TNF alpha blockade in rheumatoid arthritis: rationale, clinical outcomes and mechanisms of action

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23273

Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23273

Molecular pathology of type 1 diabetes.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23273

Virus proteins that counteract host immune defenses

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23273

Herpes simplex virus turns off the TAP to evade host immunity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23273

Coexpression of B7-1 and viral ("self") transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23273

Analyses of the cytotoxic T lymphocyte responses to glycoprotein and nucleoprotein components of lymphocytic choriomeningitis virus

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23273

Fine dissection of a nine amino acid glycoprotein epitope, a major determinant recognized by lymphocytic choriomeningitis virus-specific class I-restricted H-2Db cytotoxic T lymphocytes

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23273

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23273

Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23273

How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model

28 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.94.18.9808

A viral inhibitor of peptide transporters for antigen presentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.94.18.9808

Major histocompatibility complex class I deficiency prolongs islet allograft survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.94.18.9808

Transient expression of genes transferred in vivo into heart using first-generation adenoviral vectors: role of the immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.94.18.9808

Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23273

Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic β cells

20 September 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.94.18.9808

An adenovirus type 2 glycoprotein blocks cell surface expression of human histocompatibility class I antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.94.18.9808

A Molecular Basis for MHC Class II—Associated Autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.94.18.9808

Indefinite survival of MHC class I-deficient murine pancreatic islet allografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.94.18.9808

21 January 2018

Identifiers

DOI

10.1073/PNAS.94.18.9808

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15 August 2017

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1 reference

15 August 2017

PubMed publication ID

9275207

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