Mechanisms of disease: Pre-eclampsia (Q36577103)

15 August 2017

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title

Mechanisms of disease: Pre-eclampsia (English)

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15 August 2017

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Giuseppe Remuzzi

3

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author name string

Marina Noris

series ordinal

1

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PubMed ID

16932375

15 August 2017

Norberto Perico

series ordinal

2

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15 August 2017

1 December 2005

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Nature Clinical Practice Nephrology

15 August 2017

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15 August 2017

1

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15 August 2017

2

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15 August 2017

98-114; quiz 120

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Eclampsia: a 13-year experience at a United States tertiary care center.

15 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

Changing paternity and the risk of preeclampsia/eclampsia in the subsequent pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

Accuracy of urinalysis dipstick techniques in predicting significant proteinuria in pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

World Health Organization systematic review of screening tests for preeclampsia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

Histomorphometry of the human placenta in maternal preeclampsia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

Human trophoblast invasion and spiral artery transformation: the role of nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

Angiopoietin-1 and angiopoietin-2 activate trophoblast Tie-2 to promote growth and migration during placental development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

Invasive cytotrophoblasts manifest evidence of oxidative stress in preeclampsia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia, and intrauterine growth retardation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

Forearm blood flow in pre‐eclampsia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

Nitric oxide in different types of hypertension during pregnancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

Vascular endothelial growth factor enhances glomerular capillary repair and accelerates resolution of experimentally induced glomerulonephritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

Lipid peroxidation in pregnancy: new perspectives on preeclampsia

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCPNEPH0035

Reversible intracerebral pathologic entities mediated by vascular autoregulatory dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

Evidence of accelerated platelet production and consumption in nonthrombocytopenic preeclampsia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

Maternal mortality: confidential enquiries into maternal deaths in the United Kingdom

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

The relationship between calcium intake and edema-, proteinuria-, and hypertension-getosis: an hypothesis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

The Interval between Pregnancies and the Risk of Preeclampsia

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https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

The birth interval hypothesis-does it really indicate the end of the primipaternity hypothesis

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https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies

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https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Pre-eclampsia matters

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https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

1 reference

7 January 2021

Increased frequency of genetic thrombophilia in women with complications of pregnancy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Role of malnutrition in pre-eclampsia and eclampsia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

A molecular variant of angiotensinogen associated with preeclampsia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Evidence for a familial pregnancy-induced hypertension locus in the eNOS-gene region

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

The factor V Leiden mutation may predispose women to severe preeclampsia.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia

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https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Factor V Leiden and thermolabile methylenetetrahydrofolate reductase gene variants in an East Anglian preeclampsia cohort

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https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Susceptibility loci for preeclampsia on chromosomes 2p25 and 9p13 in Finnish families

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https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

A genome-wide scan for preeclampsia in the Netherlands

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https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

A genome scan in families from Australia and New Zealand confirms the presence of a maternal susceptibility locus for pre-eclampsia, on chromosome 2

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

The parent-of-origin effect of 10q22 in pre-eclamptic females coincides with two regions clustered for genes with down-regulated expression in androgenetic placentas

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Disentangling fetal and maternal susceptibility for pre-eclampsia: a British multicenter candidate-gene study

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Should the definition of preeclampsia include a rise in diastolic blood pressure of >/=15 mm Hg to a level <90 mm Hg in association with proteinuria?

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Random urinary protein-to-creatinine ratio for prediction of significant proteinuria in women with preeclampsia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

The detection, investigation and management of hypertension in pregnancy: executive summary

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

ACOG technology assessment. Genetics and molecular diagnostic testing. Number 1, July 2002. American College of Obstetrics and Gynecology

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https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Risk for subsequent coronary artery disease after preeclampsia

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https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Severe maternal morbidity associated with hypertensive disorders in pregnancy in the United States

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https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Adverse perinatal outcomes are significantly higher in severe gestational hypertension than in mild preeclampsia

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https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Pre-eclampsia and the hypertensive disorders of pregnancy

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https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Priming and remodelling of human placental bed spiral arteries during pregnancy--a review

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome?

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Pre-eclampsia and Maternal Anaemia Display Reduced Apoptosis and Opposite Invasive Phenotypes of Extravillous Trophoblast

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https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

The frequency and severity of placental findings in women with preeclampsia are gestational age dependent

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Natural killer cells and pregnancy

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https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

NK cells and trophoblasts: partners in pregnancy

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https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion?

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Expression of mRNA for vascular endothelial growth factor in human placenta

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

VEGF mRNA levels in placentae from pregnancies complicated by pre-eclampsia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Circulating angiogenic factors and the risk of preeclampsia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Trophoblast expression of fms-like tyrosine kinase 1 is not required for the establishment of the maternal-fetal interface in the mouse placenta

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

The L-arginine-nitric oxide pathway

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https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Nitric oxide synthase activity and localization do not change in uterus and placenta during human parturition.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Expression of endothelial nitric oxide synthase by extravillous trophoblast cells in the human placenta

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Immunohistochemical localization of endothelial nitric oxide synthase in human villous and extravillous trophoblast populations and expression during syncytiotrophoblast formation in vitro.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Placental endothelial nitric oxide synthase localization and expression in normal human pregnancy and pre-eclampsia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Regulation of metalloproteinases by nitric oxide in human trophoblast cells in culture

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

New aspects in the pathophysiology of preeclampsia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Induction of VE-cadherin in rat placental trophoblasts by VEGF through a NO-dependent pathway

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

The role of vasoactive molecules of endothelial origin in the pathophysiology of normal pregnancy and pregnancy-induced hypertension

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Superoxide production and reactive oxygen species signaling by endothelial nitric-oxide synthase

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury

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https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors

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https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

L-arginine depletion in preeclampsia orients nitric oxide synthase toward oxidant species

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Single-channel basis for conductance increase induced by isoflurane in Shaker H4 IR K(+) channels

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Nitric oxide dysfunction in the pathophysiology of preeclampsia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Early second-trimester maternal hyperandrogenemia and subsequent preeclampsia: a prospective study

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Evidence Supporting a Beneficial Role for Long-Term L-Arginine Supplementation in High-Risk Pregnancies

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Effect of quercetine and glutathione on the level of superoxide dismutase, catalase, malonyldialdehyde, blood pressure and neonatal outcome in a rat model of pre-eclampsia induced by NG-nitro-L-arginine-methyl ester

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Adriana and Luisa Castellucci Award lecture 2001. Hypoxia inducible factor-1: oxygen regulation of trophoblast differentiation in normal and pre-eclamptic pregnancies--a review

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Inhibition of TGF-beta 3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Role of the renin-angiotensin system in the pathogenesis of preeclampsia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

The renin-aldosterone system during normal and hypertensive pregnancy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Eicosanoids in preeclampsia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

The role of nitric oxide in the pathogenesis of preeclampsia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Plasma concentrations of endogenous inhibitor of nitric oxide synthesis in normal pregnancy and pre-eclampsia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Cyclic guanosine 3',5' monophosphate concentrations in pre-eclampsia: effects of hydralazine

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Preeclampsia. Part 1: clinical and pathophysiologic considerations

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Soluble fms-like Tyrosine Kinase 1

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Circulating levels of the antiangiogenic marker sFLT-1 are increased in first versus second pregnancies

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Soluble VEGF receptor Flt1: the elusive preeclampsia factor discovered?

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Hypoxia-induced increase in soluble Flt-1 production correlates with enhanced oxidative stress in trophoblast cells from the human placenta

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Reductions of vascular endothelial growth factor and placental growth factor concentrations in severe preeclampsia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Urinary Placental Growth Factor and Risk of Preeclampsia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Neutralization of Circulating Vascular Endothelial Growth Factor (VEGF) by Anti-VEGF Antibodies and Soluble VEGF Receptor 1 (sFlt-1) Induces Proteinuria

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Pre-eclampsia and trisomy 13: a possible association

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Increased AT(1) receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

AT(1) receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factor

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human mesangial cells and induce interleukin-6 and plasminogen activator inhibitor-1 secretion

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human trophoblast cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

High glucose causes upregulation of cyclooxygenase-2 and alters prostanoid profile in human endothelial cells: role of protein kinase C and reactive oxygen species

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Effects of prolonged oral supplementation with l-arginine on blood pressure and nitric oxide synthesis in preeclampsia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Vitamin C and E supplementation in women at risk of preeclampsia is associated with changes in indices of oxidative stress and placental function

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

The vitamin E debate: implications for ongoing trials of pre-eclampsia prevention

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Hepatic infarction in preeclampsia as part of the HELLP syndrome: CT appearance

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Markers for endothelial injury, clotting and platelet activation in preeclampsia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Unraveling the mysteries of preeclampsia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0035

7 January 2021

Identifiers

DOI

10.1038/NCPNEPH0035

1 reference

15 August 2017

1 reference

PubMed ID

16932375