Asthma: defining of the persistent adult phenotypes (Q36578781)

15 August 2017

1 reference

title

Asthma: defining of the persistent adult phenotypes (English)

1 reference

15 August 2017

0 references

1 reference

Sally E Wenzel

1

1 reference

PubMed ID

16935691

15 August 2017

language of work or name

English

0 references

publication date

1 August 2006

1 reference

15 August 2017

1 reference

15 August 2017

368

1 reference

15 August 2017

9537

1 reference

15 August 2017

804-813

1 reference

Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics

15 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Aspirin-induced asthma: advances in pathogenesis, diagnosis, and management

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

1 reference

7 January 2021

Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Severity assessment in asthma: An evolving concept

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Evidence of a role of tumor necrosis factor alpha in refractory asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

IL-11 expression is increased in severe asthma: association with epithelial cells and eosinophils.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Increased TGF-beta2 in severe asthma with eosinophilia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Differences in airway remodeling between subjects with severe and moderate asthma.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Neutrophilic inflammation in severe persistent asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Difficult-to-control asthma: clinical characteristics of steroid-insensitive asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Psychopathology in patients with severe asthma is associated with increased health care utilization

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Chemosensitivity and perception of dyspnea in patients with a history of near-fatal asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Dyspnoea at rest and at the end of different exercises in patients with near-fatal asthma.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Progression of asthma measured by lung function in the childhood asthma management program

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Polymorphisms in the IL4, IL4RA, and FCERIB genes and asthma severity

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

TGFbeta1 allele association with asthma severity.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Severe asthma treatment: need for characterising patients

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Steroid resistance in asthma: a major problem requiring novel solutions or a non-issue?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Significant variability in response to inhaled corticosteroids for persistent asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Corticosteroid-resistant bronchial asthma is associated with increased c-fos expression in monocytes and T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Decreased steroid responsiveness at night in nocturnal asthma. Is the macrophage responsible?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Histone acetylation and deacetylation: importance in inflammatory lung diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Low sputum eosinophils predict the lack of response to beclomethasone in symptomatic asthmatic patients

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Non-eosinophilic cor ticosteroid unresponsive asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

A randomized controlled trial on the effect of inhaled corticosteroids on airways inflammation in adult cigarette smokers

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Factors associated with persistent airflow limitation in severe asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Mortality and decline in lung function in 213 adults with bronchial asthma: a ten-year follow up

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

A 10 year follow up of 180 adults with bronchial asthma: factors important for the decline in lung function

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Proinflammatory cytokines in nasal secretions of allergic subjects after antigen challenge

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Environmental exposure to endotoxin and its relation to asthma in school-age children

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

High-affinity IgE receptor (FcepsilonRI)-bearing cells in bronchial biopsies from atopic and nonatopic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

1 reference

7 January 2021

Airway mucosal inflammation in occupational asthma induced by toluene diisocyanate

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Bronchial inflammation in occupational asthma due to western red cedar

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Reactive airways dysfunction syndrome due to chlorine: sequential bronchial biopsies and functional assessment

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Enhanced expression of the leukotriene C(4) synthase due to overactive transcription of an allelic variant associated with aspirin-intolerant asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Leukotriene-receptor expression on nasal mucosal inflammatory cells in aspirin-sensitive rhinosinusitis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Expression of interleukin-5 and granulocyte-macrophage colony-stimulating factor in aspirin-sensitive and non-aspirin-sensitive asthmatic airways

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Near-fatal asthma related to menstruation.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Female steroid hormones use signal transducers and activators of transcription protein-mediated pathways to modulate the expression of T-bet in epithelial cells: a mechanism for local immune regulation in the human reproductive tract

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Estrogen and progestagens differentially modulate vascular proinflammatory factors

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

IL-1beta-mediated proinflammatory responses are inhibited by estradiol via down-regulation of IL-1 receptor type I in uterine epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Female mice are more susceptible to the development of allergic airway inflammation than male mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Progesterone increases airway eosinophilia and hyper‐responsiveness in a murine model of allergic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Airway inflammation in premenstrual asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Spirometry and airway reactivity in elite track and field athletes.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Evidence of airway inflammation and remodeling in ski athletes with and without bronchial hyperresponsiveness to methacholine.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Airway immunopathology of asthma with exercise-induced bronchoconstriction

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Thermally induced asthma and airway drying.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

An investigation of the effects of heat and water exchange in the recovery period after exercise in children with asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

A comparative study of the effects of an inhaled corticosteroid, budesonide, and a β2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: A randomized, double-blind, parallel-group controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Serum levels of soluble IL-2R, IL-4, and soluble Fc epsilon RII in adult bronchial asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Evaluation of serum eosinophil cationic protein as a predictive marker for asthma exacerbation in patients with persistent disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen deposition

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Granulocyte activation markers in induced sputum: comparison between chronic obstructive pulmonary disease, asthma, and normal subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Comparison of leukocyte counts in sputum, bronchial biopsies, and bronchoalveolar lavage

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Heterogeneity of airway inflammation in persistent asthma : evidence of neutrophilic inflammation and increased sputum interleukin-8.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Eosinophilic Inflammation in Asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

The relationship between airways inflammation and asthma severity

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Relationship between induced sputum eosinophils and the clinical pattern of childhood asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Exhaled nitric oxide identifies the persistent eosinophilic phenotype in severe refractory asthma.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Use of exhaled nitric oxide measurements to guide treatment in chronic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Alveolar nitric oxide in adults with asthma: evidence of distal lung inflammation in refractory asthma.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

"Refractory" eosinophilic airway inflammation in severe asthma: effect of parenteral corticosteroids

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Time to death, airway wall inflammation and remodelling in fatal asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Asthma and cigarette smoking.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Bronchoalveolar neutrophilia during late asthmatic reactions induced by toluene diisocyanate

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Increase in airway neutrophils after oral but not inhaled corticosteroid therapy in mild asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoids

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation, and wound repair.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Characterization of within-subject responses to fluticasone and montelukast in childhood asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

Sputum analysis, bronchial hyperresponsiveness, and airway function in asthma: results of a factor analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2806%2969290-8

7 January 2021

10.1016/S0140-6736(06)69290-8

Identifiers

DOI

1 reference

15 August 2017

1 reference

PubMed ID

16935691