A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease (Q36580714)

15 August 2017

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A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease (English)

1 reference

15 August 2017

1 reference

19

Alexis Brice

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Florian Mittag

Florian Mittag

13

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Finja Büchel

Finja Buchel

7

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Huw R Morris

Huw R Morris

29

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Claudia Schulte

Claudia Schulte

15

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Maria Martinez

Maria Martinez

25

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Jose Bras

Jose M Bras

9

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Peter Holmans

Peter Holmans

1

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Nicholas W. Wood

Nicholas W Wood

International Parkinson's Disease Genomics Consortium

24

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5

International Parkinson's Disease Genomics Consortium

1 reference

15 August 2017

22

Thomas Gasser

1 reference

15 August 2017

28

John Hardy

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15 August 2017

23

Peter Heutink

1 reference

15 August 2017

17

Rita Guerreiro

1 reference

15 August 2017

16

Alexandra Durr

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15 August 2017

26

Andrew B Singleton

1 reference

15 August 2017

4

Manu Sharma

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15 August 2017

18

Dena Hernandez

1 reference

ORCID Public Data File 2021

15 August 2017

1 reference

J Raphael Gibbs

14

J Raphael Gibbs

1 reference

15 August 2017

3

Lesley Jones

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15 August 2017

Valentina Escott-Price

2

Valentina Moskvina

1 reference

15 August 2017

6

Alexey Vedernikov

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15 August 2017

11

Nayia Nicolaou

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15 August 2017

12

Javier Simón-Sánchez

1 reference

15 August 2017

20

Hreinn Stefánsson

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15 August 2017

21

Kari Majamaa

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15 August 2017

27

Michael A Nalls

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15 August 2017

Mohamad Saad

8

1 reference

15 August 2017

Francesco Bettella

10

1 reference

15 August 2017

Nigel M Williams

30

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15 August 2017

7 December 2012

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15 August 2017

Human Molecular Genetics

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15 August 2017

22

1 reference

15 August 2017

5

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15 August 2017

1039-1049

1 reference

Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease

15 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Direct observation of the interconversion of normal and toxic forms of α-synuclein

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

KEGG for integration and interpretation of large-scale molecular data sets

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

A two-stage meta-analysis identifies several new loci for Parkinson's disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Genome-wide association study confirms extant PD risk loci among the Dutch

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

CD3 in Lewy pathology: does the abnormal recall of neurodevelopmental processes underlie Parkinson's disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Genome-wide association study reveals genetic risk underlying Parkinson's disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Using prior knowledge and genome-wide association to identify pathways involved in multiple sclerosis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Pathway and network-based analysis of genome-wide association studies in multiple sclerosis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Innate and adaptive immunity for the pathobiology of Parkinson's disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

The effect of onset age on the clinical features of Parkinson's disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Genomewide association study for susceptibility genes contributing to familial Parkinson disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Whole genome survey of coding SNPs reveals a reproducible pathway determinant of Parkinson disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

The Mouse Genome Database (MGD): mouse biology and model systems

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Pathway-based approaches for analysis of genomewide association studies

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

A genomic pathway approach to a complex disease: axon guidance and Parkinson disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

High-resolution whole-genome association study of Parkinson disease.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

A common LRRK2 mutation in idiopathic Parkinson's disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

The Gene Ontology (GO) database and informatics resource

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Incidence of Parkinson's disease: variation by age, gender, and race/ethnicity

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Alzheimer's disease and Parkinson's disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Peripheral cytokines profile in Parkinson's disease.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

Genome-wide association study confirms BST1 and suggests a locus on 12q24 as the risk loci for Parkinson's disease in the European population

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

LRRK2 is expressed in B-2 but not in B-1 B cells, and downregulated by cellular activation.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

On multiple-testing correction in genome-wide association studies

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

p53 protein, interferon-gamma, and NF-kappaB levels are elevated in the parkinsonian brain.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561909

An improved Bonferroni procedure for multiple tests of significance

20 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FHMG%2FDDS492

21 January 2018

Identifiers

DOI

10.1093/HMG/DDS492

1 reference

15 August 2017

1 reference

15 August 2017

1 reference