Pharmacological utility of melatonin in the treatment of septic shock: experimental and clinical evidence (Q36582757)

15 August 2017

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title

Pharmacological utility of melatonin in the treatment of septic shock: experimental and clinical evidence (English)

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15 August 2017

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Russel J Reiter

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15 August 2017

Marina Sánchez Hidalgo

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object named as

Marina Sánchez-Hidalgo

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15 August 2017

Germaine Escames

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15 August 2017

Darío Acuña-Castroviejo

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15 August 2017

Luis Carlos López

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15 August 2017

Dun-xian Tan

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15 August 2017

Maria Dolores Maldonado

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15 August 2017

Josefa León

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1 September 2006

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Journal of Pharmacy and Pharmacology

15 August 2017

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15 August 2017

58

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9

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15 August 2017

1153-1165

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Melatonin, mitochondria, and cellular bioenergetics

15 August 2017

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https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin, mitochondrial homeostasis and mitochondrial-related diseases

21 January 2018

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https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin and nitric oxide: two required antagonists for mitochondrial homeostasis

21 January 2018

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https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Role of the neutrophil in septic shock and the adult respiratory distress syndrome

21 January 2018

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https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

The chemistry of melatonin's interaction with reactive species

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Epidemiology of sepsis: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

21 January 2018

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https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis

21 January 2018

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Sepsis in the critically ill patient

21 January 2018

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https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin modulates mesenteric blood flow and TNFalpha concentrations after lipopolysaccharide challenge

21 January 2018

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https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide

21 January 2018

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The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group

21 January 2018

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Efficacy and safety of recombinant human activated protein C for severe sepsis

21 January 2018

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Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome

21 January 2018

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Nitrosation of melatonin by nitric oxide and peroxynitrite

21 January 2018

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https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

The role of mitochondrial nitric oxide synthase in inflammation and septic shock

21 January 2018

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https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

An assessment of plasma histamine concentrations during documented endotoxic shock

21 January 2018

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Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase

21 January 2018

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https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Analysis of the pathways of nitric oxide utilization in mitochondria

21 January 2018

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https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

The international sepsis forum consensus conference on definitions of infection in the intensive care unit

21 January 2018

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https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Depletion of liver glutathione potentiates the oxidative stress and decreases nitric oxide synthesis in a rat endotoxin shock model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Nitric oxide, complex I, and the modulation of mitochondrial reactive species in biology and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin protects against MPTP/MPP+ -induced mitochondrial DNA oxidative damage in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

The immunopathogenesis of sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Plasma antioxidant potential in severe sepsis: a comparison of survivors and nonsurvivors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Severity of sepsis alters the effects of superoxide anion inhibition in a rat sepsis model

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Risk and the efficacy of antiinflammatory agents: retrospective and confirmatory studies of sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Biochemistry of mitochondrial nitric-oxide synthase

21 January 2018

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https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin and vitamin E limit nitric oxide-induced lipid peroxidation in rat brain homogenates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Mechanisms of N-methyl-D-aspartate receptor inhibition by melatonin in the rat striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin counteracts inducible mitochondrial nitric oxide synthase-dependent mitochondrial dysfunction in skeletal muscle of septic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin alleviates behavioral deficits associated with apoptosis and cholinergic system dysfunction in the APP 695 transgenic mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Reactive oxygen species as mediators of organ dysfunction caused by sepsis, acute respiratory distress syndrome, or hemorrhagic shock: potential benefits of resuscitation with Ringer's ethyl pyruvate solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Increased levels of malondialdehyde and nitrite/nitrate in the blood of asphyxiated newborns: reduction by melatonin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Effects of melatonin treatment in septic newborns.

21 January 2018

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https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Oxidative and inflammatory parameters in respiratory distress syndrome of preterm newborns: beneficial effects of melatonin

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin reduces oxidative stress in surgical neonates.

21 January 2018

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https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Production of nitric oxide by mitochondria

21 January 2018

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https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Advances in sepsis therapy

21 January 2018

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https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

LPS induction of gene expression in human monocytes

21 January 2018

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https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Redox imbalance in the critically ill.

21 January 2018

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https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

The endothelium in sepsis: source of and a target for inflammation

21 January 2018

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https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Innate immune recognition of lipopolysaccharide by endothelial cells

21 January 2018

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https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Inhibition of nitric oxide synthase as a potential therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Free radicals and lipid peroxidation mediated injury in burn trauma: the role of antioxidant therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

A new therapeutic approach for the treatment of sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin synthesis in retina: circadian regulation of arylalkylamine N-acetyltransferase activity in cultured photoreceptor cells of embryonic chicken retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Lipopolysaccharide-binding protein is required to combat a murine gram-negative bacterial infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Clinical trials of controlled-release melatonin in children with sleep-wake cycle disorders

21 January 2018

1 reference

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Reactive changes of interstitial glia and pinealocytes in the rat pineal gland challenged with cell wall components from gram-positive and -negative bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress-induced apoptosis of rat brain astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Identification of a neuronal nitric oxide synthase in isolated cardiac mitochondria using electrochemical detection

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Synergistic effects of melatonin and deprenyl against MPTP-induced mitochondrial damage and DA depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Prophylactic use of melatonin protects against focal cerebral ischemia in mice: role of endothelin converting enzyme-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin in higher plants: occurrence and possible functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Tumor necrosis factor alpha and interleukin 1beta are responsible for in vitro myocardial cell depression induced by human septic shock serum

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Dietary supplementation with melatonin reduces levels of amyloid beta-peptides in the murine cerebral cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin and mitochondrial function

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin mitigates mitochondrial malfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Pathogenesis and treatment of disseminated intravascular coagulation in the septic patient

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Inactivation of catecholamines by superoxide gives new insights on the pathogenesis of septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

The epidemiology of sepsis in the United States from 1979 through 2000

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Distribution of melatonin in mammalian tissues: the relative importance of nuclear versus cytosolic localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Utility of high doses of melatonin as adjunctive anticonvulsant therapy in a child with severe myoclonic epilepsy: two years' experience.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

New issues about melatonin and its effects on the digestive system

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Heterogeneous expression of cell adhesion molecules by endothelial cells in ARDS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Impaired circadian rhythm of melatonin secretion in sedated critically ill patients with severe sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Recombinant human platelet-activating factor acetylhydrolase for treatment of severe sepsis: results of a phase III, multicenter, randomized, double-blind, placebo-controlled, clinical trial

21 January 2018

1 reference

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The protective effect of N-acetylcysteine on apoptotic lung injury in cecal ligation and puncture-induced sepsis model

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Pathogenetic mechanisms of septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin treatment protects against sepsis-induced functional and biochemical changes in rat ileum and urinary bladder

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Molecular basis of endothelial dysfunction in sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Ventilation with lower tidal volumes versus traditional tidal volumes in adults for acute lung injury and acute respiratory distress syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Drug intervention trials in sepsis: divergent results

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin: an antioxidant in edible plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

What constitutes a physiological concentration of melatonin?

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: a review of the evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin relieves the neural oxidative burden that contributes to dementias

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

The pineal gland hormone melatonin improves survival in a rat model of sepsis/shock induced by zymosan A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Regulation of antioxidant enzymes: a significant role for melatonin

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Therapeutic potential of superoxide dismutase mimetics as therapeutic agents in critical care medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Epidemiology of sepsis syndrome in 8 academic medical centers

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Acute renal failure and sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin protects against oxidative organ injury in a rat model of sepsis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin administration prevents lipopolysaccharide-induced oxidative damage in phenobarbital-treated animals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

On the role of melatonin in skin physiology and pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

The pathogenesis of septic shock.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Purification and characterization of a nitric-oxide synthase from rat liver mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Microglia play a role in mediating the effects of cytokines on the structure and function of the rat pineal gland

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Membrane-permeable radical scavengers (tempol) for shock, ischemia-reperfusion injury, and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Nitric oxide in septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin induces gamma-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

21 January 2018

Cyclooxygenases 1 and 2

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Immune cells: free radicals and antioxidants in sepsis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin protects fetal rat brain against oxidative mitochondrial damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin attenuates isoproterenol-induced protein kinase A overactivation and tau hyperphosphorylation in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Assessment of ability of murine and human anti-lipid A monoclonal antibodies to bind and neutralize lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Molecular structure of free radicals and their importance in biological reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

L-arginine transport and sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin prevents endotoxin-induced circulatory failure in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

The human pineal gland and melatonin in aging and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

Melatonin increases glutathione peroxidase activity and deformability of erythrocytes in septic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.58.9.0001

21 January 2018

Identifiers

DOI

10.1211/JPP.58.9.0001

1 reference

15 August 2017

1 reference