The twenty-year story of a plant-based vaccine against hepatitis B: stagnation or promising prospects? (Q36590168)

15 August 2017

2 references

4 November 2019

25 October 2022

1 reference

The twenty-year story of a plant-based vaccine against hepatitis B: stagnation or promising prospects? (English)

1 reference

genetically modified plant

15 August 2017

1 reference

4 November 2019

1 reference

22 October 2019

1 reference

4 November 2019

1

Tomasz Pniewski

1 reference

PMCID

3565360

15 August 2017

language of work or name

English

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publication date

21 January 2013

8 references

International Journal of Molecular Sciences

15 August 2017

23 March 2019

21 March 2019

20 June 2019

29 June 2019

22 October 2019

4 November 2019

25 October 2022

8 references

15 August 2017

23 March 2019

21 March 2019

20 June 2019

29 June 2019

22 October 2019

4 November 2019

25 October 2022

14

1 reference

15 August 2017

1

1 reference

15 August 2017

1978-1998

1 reference

Creative Commons Attribution 3.0 Unported

15 August 2017

7 references

23 March 2019

21 March 2019

20 June 2019

29 June 2019

22 October 2019

4 November 2019

on focus list of Wikimedia project

25 October 2022

copyright status

copyrighted

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ScienceSource

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cites work

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9 September 2017

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Hepatitis B virus morphogenesis

9 September 2017

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Saponin-adjuvanted particulate vaccines for clinical use.

9 September 2017

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Hepatitis B virus infection: epidemiology and vaccination

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Expression of hepatitis B surface antigen in transgenic banana plants

9 September 2017

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9 September 2017

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9 September 2017

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Immunogenicity in humans of an edible vaccine for hepatitis B.

9 September 2017

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Envelopment of the hepatitis B virus nucleocapsid

9 September 2017

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Critical overview and outlook: pathogenesis, prevention, and treatment of hepatitis and hepatocarcinoma caused by hepatitis B virus

9 September 2017

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A "NEW" ANTIGEN IN LEUKEMIA SERA

9 September 2017

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Role of secretory antibodies in the defence against infections

9 September 2017

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9 September 2017

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A plant signal peptide-hepatitis B surface antigen fusion protein with enhanced stability and immunogenicity expressed in plant cells

9 September 2017

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Immunity induced after a feed of antigen during early life: oral tolerance v. sensitisation

9 September 2017

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Oral immunization with hepatitis B surface antigen expressed in transgenic plants

9 September 2017

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9 September 2017

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9 September 2017

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Immune response to a new hepatitis B vaccine in healthcare workers who had not responded to standard vaccine: randomised double blind dose-response study

9 September 2017

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Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.

9 September 2017

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Tolerance, danger, and the extended family

9 September 2017

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Immunogenicity of transgenic plant-derived hepatitis B surface antigen

9 September 2017

1 reference

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Expression of hepatitis B surface antigen in transgenic plants

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565360

Plant expression, lyophilisation and storage of HBV medium and large surface antigens for a prototype oral vaccine formulation

9 September 2017

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Comparative immunogenicity of a PreS/S hepatitis B vaccine in non- and low responders to conventional vaccine

30 September 2017

1 reference

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Risk analysis for plant-made vaccines

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565360

Secretion of hepatitis B surface antigen in transformed tobacco cell suspension cultures

30 September 2017

1 reference

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Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565360

Hepatitis B surface antigen (HBsAg) expression in plant cell culture: Kinetics of antigen accumulation in batch culture and its intracellular form

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565360

Antibody responses to preS components after immunization of children with low doses of BioHepB.

30 September 2017

1 reference

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Physicochemical and immunological characterization of hepatitis B virus envelope particles exclusively consisting of the entire L (pre-S1 + pre-S2 + S) protein

30 September 2017

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Expression of hepatitis B virus middle and large surface antigen genes in Saccharomyces cerevisiae.

30 September 2017

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Enterically induced immunologic tolerance. I. Induction of suppressor T lymphoyctes by intragastric administration of soluble proteins

30 September 2017

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Production of highly concentrated, heat-stable hepatitis B surface antigen in maize

30 September 2017

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Bioencapsulation of the hepatitis B surface antigen and its use as an effective oral immunogen

28 June 2018

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Low-dose oral immunization with lyophilized tissue of herbicide-resistant lettuce expressing hepatitis B surface antigen for prototype plant-derived vaccine tablet formulation

28 June 2018

1 reference

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A DNA replicon system for rapid high-level production of virus-like particles in plants

28 June 2018

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Expression of the human hepatitis B virus large surface antigen gene in transgenic tomato plants

28 June 2018

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Human hepatitis B vaccine from recombinant yeast

28 June 2018

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Absorption of antigens after oral immunisation and the simultaneous induction of specific systemic tolerance

28 June 2018

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28 June 2018

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Extremely high-level and rapid transient protein production in plants without the use of viral replication

20 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565360

Synthesis of hepatitis B virus surface antigen in tomato plants transgenic for the preS2-S gene

20 September 2018

1 reference

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Immunogenicity of recombinant hepatitis B virus surface antigen fused with preS1 epitopes expressed in rice seeds

20 September 2018

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20 September 2018

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20 September 2018

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Solution conformation of an immunodominant epitope in the hepatitis B virus preS2 surface antigen

20 September 2018

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Expression, purification and characterization of the Hepatitis B virus entire envelope large protein in Pichia pastoris

20 September 2018

1 reference

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Recombinant virus-like particles as a carrier of B- and T-cell epitopes of hepatitis C virus (HCV).

20 September 2018

1 reference

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Rapid, high-level production of hepatitis B core antigen in plant leaf and its immunogenicity in mice

20 September 2018

1 reference

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The use of viral vectors to produce hepatitis B virus core particles in plants

20 September 2018

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Virus-like particle expression and assembly in plants: hepatitis B and Norwalk viruses

20 September 2018

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Expression of the hepatitis B surface S and preS2 antigens in tubers of Solanum tuberosum.

20 September 2018

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Immune responses in human volunteers upon oral administration of a rodent-adapted strain of poliomyelitis virus

20 September 2018

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Recombinant hepatitis B core antigen carrying preS1 epitopes induce immune response against chronic HBV infection.

20 September 2018

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Efficacy of GM-CSF as an Adjuvant to Hepatitis B Vaccination in Patients with Chronic Renal Failure—Results of a Prospective, Randomized Trial

20 September 2018

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Oral immunization of animals with transgenic cherry tomatillo expressing HBsAg

20 September 2018

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Activation of antigen-presenting cells by immunostimulatory plant DNA: a natural resource for potential adjuvant.

20 September 2018

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Toward the global elimination of hepatitis B virus transmission

20 September 2018

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Induction of strong hepatitis B virus (HBV) specific T helper cell and cytotoxic T lymphocyte responses by therapeutic vaccination in the trimera mouse model of chronic HBV infection.

20 September 2018

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Oral administration of hepatitis E virus-like particles induces a systemic and mucosal immune response in mice

20 September 2018

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Mucosal immunization against hepatitis B virus by intranasal co-administration of recombinant hepatitis B surface antigen and recombinant cholera toxin B subunit as an adjuvant

20 September 2018

1 reference

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A plant-derived edible vaccine against hepatitis B virus.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565360

Application of the human hepatitis B virus core antigen from transgenic tobacco plants for serological diagnosis

20 September 2018

1 reference

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Production of hepatitis B surface antigen in transgenic plants for oral immunization

20 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.3390%2FIJMS14011978

Evaluation of the immune response following a short oral vaccination schedule with hepatitis B antigen encapsulated into alginate-coated chitosan nanoparticles

21 January 2018

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Crossref

https://api.crossref.org/works/10.3390%2FIJMS14011978

Physical, chemical and immunological stability of CHO-derived hepatitis B surface antigen (HBsAg) particles

21 January 2018

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12 December 2020

Expression of hepatitis B surface antigen in tobacco cell suspension cultures

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12 December 2020

Mucosal immunization using recombinant plant-based oral vaccines

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12 December 2020

Nanogram doses of alum-adjuvanted HBs antigen induce humoral immune response in mice when orally administered

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12 December 2020

Oral immunization against hepatitis B using bile salt stabilized vesicles (bilosomes)

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12 December 2020

Oral administration of low doses of plant-based HBsAg induced antigen-specific IgAs and IgGs in mice, without increasing levels of regulatory T cells

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12 December 2020

Recombinant interferon-alpha therapy for acute hepatitis B: a randomized, double-blind, placebo-controlled trial

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12 December 2020

Oral immunization of human with transgenic lettuce expressing hepatitis B surface antigen

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12 December 2020

Improved immunogenicity in mice of a mammalian cell-derived recombinant hepatitis B vaccine containing pre-S1 and pre-S2 antigens as compared with conventional yeast-derived vaccines

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12 December 2020

Oral immunogenicity of potato-derived HBsAg middle protein in BALB/c mice

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12 December 2020

The worldwide impact of vaccination on the control and protection of viral hepatitis B

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12 December 2020

Anergic T cells actively suppress T cell responses via the antigen-presenting cell

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Modulating dendritic cells to optimize mucosal immunization protocols

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12 December 2020

Obtaining tomato plants transgenic for the preS2-S-HDEL gene, which synthesize the major hepatitis B surface antigen

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12 December 2020

Process options in hepatitis B surface antigen extraction from transgenic potato

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The newly licensed hepatitis B vaccine. Characteristics and indications for use

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A multi-center controlled study of rapid hepatitis B vaccination using a novel triple antigen recombinant vaccine

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[Analysis of transgenic tobacco plants carrying the gene for the surface antigen of the hepatitis B virus]

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Expression and characterization of hepatitis B surface antigen in transgenic potato plants

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Agrobacterium-mediated transformation of yellow lupin to generate callus tissue producing HBV surface antigen in a long-term culture

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12 December 2020

Specific vaccine therapy in chronic hepatitis B: induction of T cell proliferative responses specific for envelope antigens

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12 December 2020

The kinetics of oral hyposensitization to a protein antigen are determined by immune status and the timing, dose and frequency of antigen administration

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12 December 2020

Identifiers

DOI

10.3390/IJMS14011978

1 reference

15 August 2017

1 reference

15 August 2017

1 reference

PMCID

3565360