Controlling protein compartmentalization to overcome disease (Q36592228)

15 August 2017

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title

Controlling protein compartmentalization to overcome disease (English)

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15 August 2017

James R Davis

1

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15 August 2017

Mudit Kakar

series ordinal

2

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15 August 2017

Carol S Lim

series ordinal

3

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15 August 2017

publication date

13 September 2006

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15 August 2017

published in

Pharmaceutical Research

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15 August 2017

volume

24

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15 August 2017

issue

1

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15 August 2017

page(s)

17-27

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Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay

15 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS11095-006-9133-Z

Interactions between a nuclear transporter and a subset of nuclear pore complex proteins depend on Ran GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9133-Z

Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9133-Z

Nuclear transport and cancer: from mechanism to intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9133-Z

Phase I trial of elactocin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9133-Z

Discrimination between NL1- and NL2-mediated nuclear localization of the glucocorticoid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9133-Z

Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9133-Z

Ca2+-dependent nuclear export mediated by calreticulin

21 January 2018

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12 December 2020

A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly

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12 December 2020

BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export

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12 December 2020

Major binding sites for the nuclear import receptor are the internal nucleoporin Nup153 and the adjacent nuclear filament protein Tpr

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12 December 2020

Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export

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12 December 2020

A nuclear export signal in Kap95p is required for both recycling the import factor and interaction with the nucleoporin GLFG repeat regions of Nup116p and Nup100p

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12 December 2020

The GLFG repetitive region of the nucleoporin Nup116p interacts with Kap95p, an essential yeast nuclear import factor

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12 December 2020

Calreticulin Is a receptor for nuclear export

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12 December 2020

BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention

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12 December 2020

Structural Basis for the Cytoskeletal Association of Bcr-Abl/c-Abl

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12 December 2020

Nucleocytoplasmic shuttling of the progesterone receptor

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12 December 2020

Variants of the carboxyl-terminal KDEL sequence direct intracellular retention.

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12 December 2020

Transport into and out of the nucleus

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12 December 2020

Identification and characterization of a ligand-regulated nuclear export signal in androgen receptor

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12 December 2020

Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

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12 December 2020

Nuclear Ras: unexpected subcellular distribution of oncogenic forms

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12 December 2020

Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis

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12 December 2020

Nucleocytoplasmic transport: the soluble phase

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12 December 2020

The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review

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12 December 2020

The dopamine D3 receptor interacts with itself and the truncated D3 splice variant d3nf: D3-D3nf interaction causes mislocalization of D3 receptors

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12 December 2020

Nuclear envelope permeability

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12 December 2020

Transport between the cell nucleus and the cytoplasm

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12 December 2020

Peptide-directed suppression of a pro-inflammatory cytokine response

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12 December 2020

Ratjadone and leptomycin B block CRM1-dependent nuclear export by identical mechanisms.

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12 December 2020

A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export

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12 December 2020

DNA binding domains in diverse nuclear receptors function as nuclear export signals.

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12 December 2020

Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription

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12 December 2020

Mapping nucleolar localization sequences of 1A6/DRIM

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12 December 2020

RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains

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12 December 2020

Clinical implications of the p53 tumor-suppressor gene

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12 December 2020

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

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12 December 2020

Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain

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12 December 2020

Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa B subunit

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12 December 2020

Cytoplasmic mislocalization of p27Kip1 protein is associated with constitutive phosphorylation of Akt or protein kinase B and poor prognosis in acute myelogenous leukemia

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12 December 2020

Ratjadones inhibit nuclear export by blocking CRM1/exportin 1.

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12 December 2020

Bidirectional on/off switch for controlled targeting of proteins to subcellular compartments

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12 December 2020

Mutual regulation of c-Jun and ATF2 by transcriptional activation and subcellular localization

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12 December 2020

The LDL receptor locus in familial hypercholesterolemia: mutational analysis of a membrane protein

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12 December 2020

The location of the transport gate in the nuclear pore complex.

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12 December 2020

Steroid receptor interactions with heat shock protein and immunophilin chaperones

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12 December 2020

Mislocalization of membrane proteins associated with multidrug resistance in cisplatin-resistant cancer cell lines

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12 December 2020

Using nuclear targeting signals to enhance non-viral gene transfer

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12 December 2020

A C-terminal signal prevents secretion of luminal ER proteins

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12 December 2020

Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import

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12 December 2020

NDC1: a nuclear periphery component required for yeast spindle pole body duplication

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12 December 2020

The APC tumour suppressor has a nuclear export function.

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12 December 2020

Molecular cloning and functional expression of nucleolar phospholipid hydroperoxide glutathione peroxidase in mammalian cells

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12 December 2020

An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells

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12 December 2020

A short amino acid sequence able to specify nuclear location

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12 December 2020

Signals mediating nuclear targeting and their regulation: application in drug delivery

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12 December 2020

Nuclear localization and export signals of the human aryl hydrocarbon receptor

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12 December 2020

Mammalian alanine/glyoxylate aminotransferase 1 is imported into peroxisomes via the PTS1 translocation pathway. Increased degeneracy and context specificity of the mammalian PTS1 motif and implications for the peroxisome-to-mitochondrion mistargeti

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12 December 2020

A conserved tripeptide sorts proteins to peroxisomes

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12 December 2020

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12 December 2020

Medicine Nobel goes to pioneer of protein guidance mechanisms

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12 December 2020

A Nobel Prize for cell biology

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12 December 2020

The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their correct subcellular targeting: the N-terminal extenSion of VAMP4 contains a dominant autonomous targeting signal for the trans-Golgi network

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12 December 2020

Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase.

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12 December 2020

Nuclear targeting peptide scaffolds for lipofection of nondividing mammalian cells

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12 December 2020

Protein ZIP codes make Nobel journey

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12 December 2020

Mechanisms of Receptor-Mediated Nuclear Import and Nuclear Export

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12 December 2020

Erythropoietin promotes resistance against the Abl tyrosine kinase inhibitor imatinib (STI571) in K562 human leukemia cells.

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12 December 2020

Single translation--dual destination: mechanisms of dual protein targeting in eukaryotes

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12 December 2020

A genetic approach to mapping the p53 binding site in the MDM2 protein

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12 December 2020

Identification of a functional nuclear export sequence in BRCA1.

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12 December 2020

Importin α: a multipurpose nuclear-transport receptor

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12 December 2020

Nuclear export of the glucocorticoid receptor is accelerated by cell fusion-dependent release of calreticulin.

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12 December 2020

Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts

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12 December 2020

Mechanisms of nuclear transport and interventions

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12 December 2020

Model system to study classical nuclear export signals

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12 December 2020

Kinetic characterization of the human retinoblastoma protein bipartite nuclear localization sequence (NLS) in vivo and in vitro. A comparison with the SV40 large T-antigen NLS

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12 December 2020

Nuclear export: DNA-binding domains find a surprising partner

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12 December 2020

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

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12 December 2020

Expression of wild type and mutant ELOVL4 in cell culture: subcellular localization and cell viability.

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12 December 2020

Nuclear-cytoplasmic shuttling of BARD1 contributes to its proapoptotic activity and is regulated by dimerization with BRCA1

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12 December 2020

Mechanisms of progesterone receptor export from nuclei: role of nuclear localization signal, nuclear export signal, and ran guanosine triphosphate

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12 December 2020

Regulation of tumor suppressors by nuclear-cytoplasmic shuttling

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12 December 2020

Binding-, intracellular transport-, and biosynthesis-defective mutants of vasopressin type 2 receptor in patients with X-linked nephrogenic diabetes insipidus

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12 December 2020

In or out? Regulating nuclear transport

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12 December 2020

Nuclear transport and transcriptional regulation

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12 December 2020

Architecture of the Xenopus nuclear pore complex revealed by three-dimensional cryo-electron microscopy.

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12 December 2020

Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion

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12 December 2020

Nuclear export of phosphorylated galectin-3 regulates its antiapoptotic activity in response to chemotherapeutic drugs.

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12 December 2020

Deciphering networks of protein interactions at the nuclear pore complex

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12 December 2020

Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant

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12 December 2020

Molecular genetics of retinitis pigmentosa

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12 December 2020

NXT1 is necessary for the terminal step of Crm1-mediated nuclear export

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12 December 2020

NF-kappaB in cancer: from innocent bystander to major culprit

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12 December 2020

Mislocalization to the nuclear envelope: an effect of the dystonia-causing torsinA mutation.

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12 December 2020

Nup98 is a mobile nucleoporin with transcription-dependent dynamics

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12 December 2020

The nuclear pore complex: mediator of translocation between nucleus and cytoplasm

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12 December 2020

Molecular chaperoning of steroid hormone receptors

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12 December 2020

The nuclear export signal-dependent localization of oligonucleopeptides enhances the inhibition of the protein expression from a gene transcribed in cytosol

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12 December 2020

Effect of initial subcellular localization of progesterone receptor on import kinetics and transcriptional activity.

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12 December 2020

Bcr‐Abl upregulates cytosolic p21WAF‐1/CIP‐1 by a phosphoinositide‐3‐kinase (PI3K)‐independent pathway

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12 December 2020

Signals for sorting of transmembrane proteins to endosomes and lysosomes

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12 December 2020

A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals

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12 December 2020

Mechanisms of nuclear localization of the progesterone receptor: evidence for interaction between monomers

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12 December 2020

The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus

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12 December 2020

Correlation between structure and mass distribution of the nuclear pore complex and of distinct pore complex components

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12 December 2020

Peering through the pore: nuclear pore complex structure, assembly, and function

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12 December 2020

Nuclear transport: an emerging opportunity for drug targeting

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12 December 2020

A masked NES in INI1/hSNF5 mediates hCRM1-dependent nuclear export: implications for tumorigenesis

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12 December 2020

Dissection of a nuclear localization signal

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12 December 2020

Identification of nucleolus localization signal of betanodavirus GGNNV protein alpha

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12 December 2020

Localization of G-protein-coupled receptors in health and disease

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12 December 2020

Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors.

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12 December 2020

CRM1 is an export receptor for leucine-rich nuclear export signals

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12 December 2020

Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1

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12 December 2020

Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors

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12 December 2020

Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle

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12 December 2020

The nuclear pore complex: from molecular architecture to functional dynamics

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12 December 2020

Günter Blobel--still passionate after all these years

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12 December 2020

10.1007/S11095-006-9133-Z

Identifiers

DOI

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15 August 2017

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