Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells (Q36595297)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23115273%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

title

Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells (English)

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16 February 2020

1 reference

1

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16 February 2020

author name string

Olga Shestova

2

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16 February 2020

Lanwei Xu

3

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16 February 2020

Jon C Aster

4

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16 February 2020

Warren S Pear

5

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16 February 2020

language of work or name

English

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publication date

31 October 2012

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16 February 2020

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16 February 2020

volume

121

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16 February 2020

issue

6

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16 February 2020

page(s)

905-917

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LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance.

16 February 2020

cites work

1 reference

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Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.

9 September 2017

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A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.

9 September 2017

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Ex vivo expansion of human hematopoietic stem and progenitor cells

9 September 2017

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Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells

9 September 2017

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Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells

9 September 2017

1 reference

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Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution

9 September 2017

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Hedgehog signaling is dispensable for adult hematopoietic stem cell function

9 September 2017

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The canonical Notch signaling pathway: unfolding the activation mechanism

9 September 2017

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Targeting the Notch1 and mTOR pathways in a mouse T-ALL model

9 September 2017

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Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1

9 September 2017

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Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

Molecular genetics of T cell development

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

Notch signaling controls multiple steps of pancreatic differentiation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

Osteoblastic cells regulate the haematopoietic stem cell niche

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells

9 September 2017

1 reference

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Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells

9 September 2017

1 reference

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The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells

9 September 2017

1 reference

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Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1.

9 September 2017

1 reference

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A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome

30 September 2017

1 reference

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Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

Notch1-induced delay of human hematopoietic progenitor cell differentiation is associated with altered cell cycle kinetics

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

The Notch/Jagged pathway inhibits proliferation of human hematopoietic progenitors in vitro

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

Notch1 expression in early lymphopoiesis influences B versus T lineage determination.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567338

Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity

4 December 2018

1 reference

12 December 2020

Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell

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12 December 2020

Notch signaling induces apoptosis in primary human CD34+ hematopoietic progenitor cells

1 reference

12 December 2020

Characterization of a progenitor cell population in childhood T-cell acute lymphoblastic leukemia

1 reference

12 December 2020

The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stem cells

1 reference

12 December 2020

Expression of CD34 and CD7 on human T-cell acute lymphoblastic leukemia discriminates functionally heterogeneous cell populations

1 reference

12 December 2020

10.1182/BLOOD-2012-03-416503

Identifiers

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23115273%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

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16 February 2020

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