Repeated cycles of Clostridium-directed enzyme prodrug therapy result in sustained antitumour effects in vivo (Q36611812)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17024128%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

title

Repeated cycles of Clostridium-directed enzyme prodrug therapy result in sustained antitumour effects in vivo (English)

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20 December 2019

11

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20 December 2019

Thomas E Vaughan

5

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20 December 2019

Jozef Anné

8

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20 December 2019

Nigel P Minton

12

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20 December 2019

author name string

J Theys

1

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20 December 2019

O Pennington

2

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20 December 2019

L Dubois

3

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20 December 2019

G Anlezark

4

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20 December 2019

A Mengesha

6

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20 December 2019

W Landuyt

7

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20 December 2019

P J Burke

9

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20 December 2019

P Dûrre

10

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20 December 2019

P Lambin

13

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20 December 2019

language of work or name

English

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publication date

3 October 2006

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British Journal of Cancer

20 December 2019

published in

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20 December 2019

volume

95

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20 December 2019

issue

9

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20 December 2019

page(s)

1212-1219

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Effect of hypoxia on Ad5 infection, transgene expression and replication.

20 December 2019

cites work

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30 September 2017

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Mechanism of cell death induced by the novel enzyme-prodrug combination, nitroreductase/CB1954, and identification of synergism with 5-fluorouracil

30 September 2017

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Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

30 September 2017

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Combination bacteriolytic therapy for the treatment of experimental tumors

30 September 2017

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Combined adenovirus-mediated nitroreductase gene delivery and CB1954 treatment: a well-tolerated therapy for established solid tumors

30 September 2017

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Improvement of Clostridium tumour targeting vectors evaluated in rat rhabdomyosarcomas

30 September 2017

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Chemotherapeutic tumour targeting using clostridial spores

30 September 2017

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Further progress with oncolysis due to apathogenic clostridia

30 September 2017

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Anaerobic bacteria as a delivery system for cancer gene therapy: in vitro activation of 5-fluorocytosine by genetically engineered clostridia.

30 September 2017

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Physical characterisation of the Escherichia coli B gene encoding nitroreductase and its over-expression in Escherichia coli K12.

28 June 2018

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The pMTL nic- cloning vectors. I. Improved pUC polylinker regions to facilitate the use of sonicated DNA for nucleotide sequencing

28 June 2018

1 reference

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Colonisation of Clostridium in the body is restricted to hypoxic and necrotic areas of tumours.

28 June 2018

1 reference

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Hypoxia reduces adenoviral replication in cancer cells by downregulation of viral protein expression

20 September 2018

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Quorum sensing in Clostridium difficile: analysis of a luxS-type signalling system.

20 September 2018

1 reference

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Conjugative transfer of clostridial shuttle vectors from Escherichia coli to Clostridium difficile through circumvention of the restriction barrier

20 September 2018

1 reference

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Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis

20 September 2018

1 reference

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Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures.

20 September 2018

1 reference

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Bacillus amyloliquefaciens orthologue of Bacillus subtilis ywrO encodes a nitroreductase enzyme which activates the prodrug CB 1954.

20 September 2018

1 reference

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Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum.

20 September 2018

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Nitroreductase-mediated cell ablation is very rapid and mediated by a p53-independent apoptotic pathway

20 September 2018

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Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment

20 September 2018

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The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)

20 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJC.6603367

Chemotherapeutic tumour targeting using clostridial spores

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJC.6603367

Conjugative plasmid transfer from Escherichia coli to Clostridium acetobutylicum

21 January 2018

1 reference

12 December 2020

ONCOLYSIS BY CLOSTRIDIA. I. ACTIVITY OF CLOSTRIDIUM BUTYRICUM (M-55) AND OTHER NONPATHOGENIC CLOSTRIDIA AGAINST THE EHRLICH CARCINOMA

1 reference

12 December 2020

Introduction of genes for leucine biosynthesis from Clostridium pasteurianum into C. acetobutylicum by cointegrate conjugal transfer

1 reference

12 December 2020

Secretory production of biologically active rat interleukin-2 by Clostridium acetobutylicum DSM792 as a tool for anti-tumor treatment

1 reference

12 December 2020

Expression of cloned homologous fermentative genes in Clostridium acetobutylicum ATCC 824

1 reference

12 December 2020

Expression of Escherichia coli B nitroreductase in established human tumor xenografts in mice results in potent antitumoral and bystander effects upon systemic administration of the prodrug CB1954

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.BJC.6603367

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17024128%20AND%20SRC:MED&resulttype=core&format=json

release_3rxzaekgengixfu7aqquhcifqe

20 December 2019

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/3rxzaekgengixfu7aqquhcifqe

24 November 2022

mapped directly with Wikidata item

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17024128%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

PubMed publication ID

17024128

1 reference