Thiazolidinediones: potential as therapeutics for psoriasis and perhaps other hyperproliferative skin disease (Q36623091)

15 August 2017

1 reference

title

Thiazolidinediones: potential as therapeutics for psoriasis and perhaps other hyperproliferative skin disease (English)

1 reference

15 August 2017

James Varani

1

1 reference

15 August 2017

Narasimharao Bhagavathula

series ordinal

2

1 reference

15 August 2017

Charles N Ellis

series ordinal

3

1 reference

15 August 2017

Harrihar A Pershadsingh

series ordinal

4

1 reference

15 August 2017

language of work or name

English

0 references

publication date

1 November 2006

1 reference

Expert Opinion on Investigational Drugs

15 August 2017

1 reference

15 August 2017

15

1 reference

15 August 2017

11

1 reference

15 August 2017

1453-1468

1 reference

Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor

15 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Peroxisome proliferator activated receptors: transcriptional regulators of adipogenesis, lipid metabolism and more....

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Peroxisome proliferator-activated receptors and skin development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

The mechanisms of action of PPARs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Combinatorial control of gene expression by nuclear receptors and coregulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

In vivo activation of PPAR target genes by RXR homodimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Dysregulation of the peroxisome proliferator-activated receptor target genes by XPD mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

PPAR alpha inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

PPARgamma regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Tissue-selective, bidirectional regulation of PEX11 alpha and perilipin genes through a common peroxisome proliferator response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

The organization, promoter analysis, and expression of the human PPARgamma gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

PPARgamma3 mRNA: a distinct PPARgamma mRNA subtype transcribed from an independent promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Alpha-Lipoic acid-based PPARgamma agonists for treating inflammatory skin diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 3. Structure-activity relationship and optimization of the N-aryl substituent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Molecular recognition of fatty acids by peroxisome proliferator-activated receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Fatty acid transduction of nitric oxide signaling: multiple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferator-activated receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Role of peroxisome proliferator-activated receptor gamma and its ligands in non-neoplastic and neoplastic human urothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Peroxisome proliferator-activated receptor gamma-dependent and -independent growth inhibition of gastrointestinal tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

PPARgamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Peroxisome proliferator-activated receptor-gamma induces regression of endometrial explants in a rat model of endometriosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Pro-inflammatory properties for thiazolidinediones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Peroxisome proliferator-activated receptor gamma-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase sign

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Capsaicin, a spicy component of hot pepper, induces apoptosis by activation of the peroxisome proliferator-activated receptor gamma in HT-29 human colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Activation of PPARgamma is not involved in butyrate-induced epithelial cell differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Ligands and activators of nuclear hormone receptors regulate epidermal differentiation during fetal rat skin development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Modulation of keratinocyte gene expression and differentiation by PPAR-selective ligands and tetradecylthioacetic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Disruption of transforming growth factor beta signaling and profibrotic responses in normal skin fibroblasts by peroxisome proliferator-activated receptor gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Expression and function of peroxisome proliferator-activated receptors in human melanocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Functions of peroxisome proliferator-activated receptors (PPAR) in skin homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Peroxisome proliferator-activated receptors in cutaneous biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Troglitazone inhibits cyclin D1 expression and cell cycling independently of PPARgamma in normal mouse skin keratinocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Troglitazone improves psoriasis and normalizes models of proliferative skin disease: ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Rosiglitazone inhibits proliferation, motility, and matrix metalloproteinase production in keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

BP-1107 [{2-[4-(2,4-dioxo-thiazolidin-5-ylmethyl)-phenoxy]-ethyl}-methyl-amide]: a novel synthetic thiazolidinedione that inhibits epidermal hyperplasia in psoriatic skin-severe-combined immunodeficient mouse transplants after topical application

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Human skin levels of retinoic acid and cytochrome P-450-derived 4-hydroxyretinoic acid after topical application of retinoic acid in vivo compared to concentrations required to stimulate retinoic acid receptor-mediated transcription in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Shifts in the concentrations of magnesium and calcium in early porcine and rat wound fluids activate the cell migratory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

All-trans retinoic acid (RA) stimulates events in organ-cultured human skin that underlie repair. Adult skin from sun-protected and sun-exposed sites responds in an identical manner to RA while neonatal foreskin responds differently

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Anti-CD11a ameliorates disease in the human psoriatic skin-SCID mouse transplant model: comparison of antibody to CD11a with Cyclosporin A and clobetasol propionate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Heparin-binding epidermal-growth-factor-like growth factor activation of keratinocyte ErbB receptors Mediates epidermal hyperplasia, a prominent side-effect of retinoid therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Psoriasis: a T-cell-mediated autoimmune disease induced by streptococcal superantigens?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early-onset, psoriasis-like skin pathology: expression of amphiregulin in the basal epidermis is also associated with synovitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Separation of retinoid-induced epidermal and dermal thickening from skin irritation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Topical treatment with thiazolidinediones, activators of peroxisome proliferator-activated receptor-gamma, normalizes epidermal homeostasis in a murine hyperproliferative disease model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Regulation of cell motility by mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Association of mitogen-activated protein kinase with the microtubule cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

c-Jun-dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Enhancement of fibroblast collagenase-1 (MMP-1) gene expression by tumor promoter okadaic acid is mediated by stress-activated protein kinases Jun N-terminal kinase and p38.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Defective E-cadherin/catenin complexes in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Peroxisome proliferator-activated receptor gamma activation can regulate beta-catenin levels via a proteasome-mediated and adenomatous polyposis coli-independent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Peroxisome proliferator-activated receptor gamma inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

The annual cost of psoriasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

The mechanisms of action of cyclosporin A in the treatment of psoriasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Improvement in psoriasis with rosiglitazone in a diabetic and a nondiabetic patient

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Pioglitazone: a promising therapy for psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Pilot trial: Pioglitazone versus placebo in patients with plaque psoriasis (the P6).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Potential therapeutic role of peroxisome proliferator activated receptor-gamma agonists in psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Effect of topical PPARbeta/delta and PPARgamma agonists on plaque psoriasis. A pilot study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

PPAR-gamma agonists: therapeutic role in diabetes, inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Expression and Localization of Peroxisome Proliferator-Activated Receptors and Nuclear Factor κB in Normal and Lesional Psoriatic Skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

Loss-of-Function Mutations in PPARγ Associated with Human Colon Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.15.11.1453

10.1517/13543784.15.11.1453

21 January 2018

Identifiers

DOI

1 reference

15 August 2017

1 reference