NF-kappaB signaling: pros and cons of altering NF-kappaB as a therapeutic approach (Q36631434)

15 August 2017

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title

NF-kappaB signaling: pros and cons of altering NF-kappaB as a therapeutic approach (English)

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15 August 2017

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Laurence J Egan

1

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15 August 2017

Murat Toruner

series ordinal

2

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15 August 2017

language of work or name

English

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publication date

1 August 2006

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Annals of the New York Academy of Sciences

15 August 2017

published in

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15 August 2017

volume

1072

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15 August 2017

page(s)

114-122

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Multiple nuclear factors interact with the immunoglobulin enhancer sequences

15 August 2017

cites work

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Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism

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Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B

21 January 2018

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Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms

21 January 2018

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21 January 2018

Signaling to NF-kappaB

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The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

21 January 2018

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The IKK NF-kappa B system: a treasure trove for drug development

21 January 2018

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Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

21 January 2018

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Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa

21 January 2018

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Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis

21 January 2018

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Inhibition of interleukin-1-stimulated NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity

21 January 2018

1 reference

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The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

21 January 2018

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Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

21 January 2018

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Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti

21 January 2018

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IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis

21 January 2018

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Mature T cells depend on signaling through the IKK complex.

21 January 2018

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IkappaB kinase signaling is essential for maintenance of mature B cells

21 January 2018

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Decreased Bax expression by mucosal T cells favours resistance to apoptosis in Crohn's disease

21 January 2018

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DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA.

21 January 2018

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IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

21 January 2018

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Role of EHEC O157:H7 virulence factors in the activation of intestinal epithelial cell NF-kappaB and MAP kinase pathways and the upregulated expression of interleukin 8.

21 January 2018

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Analysis by high density cDNA arrays of altered gene expression in human intestinal epithelial cells in response to infection with the invasive enteric bacteria Salmonella

21 January 2018

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IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium

21 January 2018

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NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.

21 January 2018

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Cancer prevention in inflammatory bowel disease and the chemoprophylactic potential of 5-aminosalicylic acid

21 January 2018

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Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo

21 January 2018

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I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss

21 January 2018

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https://api.crossref.org/works/10.1196%2FANNALS.1326.009

21 January 2018

Identifiers

DOI

10.1196/ANNALS.1326.009

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15 August 2017

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