Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13. (Q36638798)

15 August 2017

Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13. (English)

1 reference

15 August 2017

1 reference

GOA release 2020-03-11

Kohtalo Dmel_CG8491

1 reference

GOA release 2020-03-11

Skuld Dmel_CG9936

1 reference

GOA release 2020-03-11

Inés Carrera

1

0 references

Florence Janody

object named as

Florence Janody

2

0 references

Jessica E Treisman

object named as

Jessica E Treisman

5

0 references

author name string

Nina Leeds

3

1 reference

15 August 2017

Fabien Duveau

4

1 reference

15 August 2017

language of work or name

English

0 references

publication date

1 May 2008

1 reference

Proceedings of the National Academy of Sciences of the United States of America

15 August 2017

1 reference

15 August 2017

105

1 reference

15 August 2017

18

1 reference

15 August 2017

6644-6649

1 reference

Transcriptional control of cell-cycle quiescence during C. elegans development

15 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

CDK8 is a stimulus-specific positive coregulator of p53 target genes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Distinct roles for Mediator Cdk8 module subunits in Drosophila development.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

A subunit of the mediator complex regulates vertebrate neuronal development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Mediator modulates Gli3-dependent Sonic hedgehog signaling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

A Mediator-responsive form of metazoan RNA polymerase II.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Transcription under the control of nuclear Arm/beta-catenin.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Zebrafish Trap230/Med12 is required as a coactivator for Sox9-dependent neural crest, cartilage and ear development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Genome-wide location of the coactivator mediator: Binding without activation and transient Cdk8 interaction on DNA.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Genome-wide occupancy profile of mediator and the Srb8-11 module reveals interactions with coding regions

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Dissecting nuclear Wingless signalling: recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

The mammalian Mediator complex and its role in transcriptional regulation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Interactions between subunits of Drosophila Mediator and activator proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

The yeast Mediator complex and its regulation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Functional genomic analysis of the Wnt-wingless signaling pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Mediator requirement for both recruitment and postrecruitment steps in transcription initiation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

The Saccharomyces cerevisiae Srb8-Srb11 complex functions with the SAGA complex during Gal4-activated transcription

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Identification and in vivo role of the Armadillo-Legless interaction.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Ras induces mediator complex exchange on C/EBP beta

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Pygopus residues required for its binding to Legless are critical for transcription and development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Srb10/Cdk8 regulates yeast filamentous growth by phosphorylating the transcription factor Ste12.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Transcriptional activating regions target a cyclin-dependent kinase.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

A component of the ARC/Mediator complex required for TGF beta/Nodal signalling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

pygopus Encodes a nuclear protein essential for wingless/Wnt signaling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Repression of Teashirt marks the initiation of wing development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Structure, function, and activator-induced conformations of the CRSP coactivator

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

TFIIH is negatively regulated by cdk8-containing mediator complexes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

A C. elegans mediator protein confers regulatory selectivity on lineage-specific expression of a transcription factor gene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Srb/mediator proteins interact functionally and physically with transcriptional repressor Sfl1.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

SSN genes that affect transcriptional repression in Saccharomyces cerevisiae encode SIN4, ROX3, and SRB proteins associated with RNA polymerase II

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

A kinase-cyclin pair in the RNA polymerase II holoenzyme.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Pygopus, a nuclear PHD-finger protein required for Wingless signaling in Drosophila

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Proximal-distal axis formation in the Drosophila leg.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Direct and long-range action of a wingless morphogen gradient

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

wingless refines its own expression domain on the Drosophila wing margin.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Transcription of the segment-polarity gene wingless in the imaginal discs of Drosophila, and the phenotype of a pupal-lethal wg mutation

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Association of an activator with an RNA polymerase II holoenzyme

28 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Two subunits of the Drosophila mediator complex act together to control cell affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Components of the transcriptional Mediator complex are required for asymmetric cell division in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

A complex of Armadillo, Legless, and Pygopus coactivates dTCF to activate wingless target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Pygopus and legless provide essential transcriptional coactivator functions to armadillo/beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Differing strategies for the establishment and maintenance of teashirt and homothorax repression in the Drosophila wing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Antagonistic interactions between wingless and decapentaplegic responsible for dorsal-ventral pattern in the Drosophila Leg.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Direct and long-range action of a DPP morphogen gradient.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Wingless-independent association of Pygopus with dTCF target genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Mediator is a transducer of Wnt/beta-catenin signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

The Ras/PKA signaling pathway directly targets the Srb9 protein, a component of the general RNA polymerase II transcription apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Control of a genetic regulatory network by a selector gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0709749105

Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373359

GAL4 Is Regulated by the RNA Polymerase II Holoenzyme–Associated Cyclin-Dependent Protein Kinase SRB10/CDK8

20 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18451032

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0709749105

1 reference

15 August 2017

0 references

1 reference

15 August 2017

PubMed publication ID

18451032

1 reference