Pharmacokinetic and pharmacodynamic properties of canakinumab, a human anti-interleukin-1β monoclonal antibody (Q36644667)

15 August 2017

1 reference

22 January 2024

Pharmacokinetic and pharmacodynamic properties of canakinumab, a human anti-interleukin-1β monoclonal antibody (English)

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cryopyrin-associated periodic syndrome

15 August 2017

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16 February 2023

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27 September 2019

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20 November 2019

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inferred from abstract

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3

Christiane Rordorf

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15 August 2017

1

Abhijit Chakraborty

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15 August 2017

2

Stacey Tannenbaum

1 reference

15 August 2017

7

Sandip Roy

1 reference

15 August 2017

5

David Floch

1 reference

15 August 2017

6

Hermann Gram

1 reference

15 August 2017

Philip J Lowe

4

1 reference

15 August 2017

1 June 2012

12 references

Clinical Pharmacokinetics

15 August 2017

12 March 2019

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12 references

15 August 2017

12 March 2019

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25 April 2019

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15 August 2017

e1-18

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15 August 2017

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https://scigraph.springernature.com/pub.10.2165/11599820-000000000-00000

15 August 2017

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Population pharmacokinetics of therapeutic monoclonal antibodies

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Use of canakinumab in the cryopyrin-associated periodic syndrome

30 September 2017

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In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes

30 September 2017

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TLR4-dependent and -independent regulation of hepatic cytochrome P450 in mice with chemically induced inflammatory bowel disease

30 September 2017

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30 September 2017

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The human anti-IL-1 beta monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis

30 September 2017

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Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes.

30 September 2017

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Interleukin-1-receptor antagonist in type 2 diabetes mellitus

30 September 2017

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A pilot study of IL-1 inhibition by anakinra in acute gout

30 September 2017

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The pharmacokinetics and pharmacodynamics of monoclonal antibodies--mechanistic modeling applied to drug development.

30 September 2017

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A mechanism-based binding model for the population pharmacokinetics and pharmacodynamics of omalizumab.

30 September 2017

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Is IL-1 a good therapeutic target in the treatment of arthritis?

30 September 2017

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Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade

30 September 2017

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Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist

30 September 2017

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NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

30 September 2017

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Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes

30 September 2017

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Imbalanced secretion of IL-1beta and IL-1RA in Chlamydia pneumoniae-infected mononuclear cells from COPD patients

30 September 2017

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De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases

30 September 2017

1 reference

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The fourth dimension of life: fractal geometry and allometric scaling of organisms.

30 September 2017

1 reference

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Induction of interleukin 1 receptor antagonist after interleukin 1 therapy in patients with cancer.

30 September 2017

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A general model for the origin of allometric scaling laws in biology

30 September 2017

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A better cell line for making hybridomas secreting specific antibodies

30 September 2017

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Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist.

28 June 2018

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Interleukin‐1β and interleukin‐1ra levels in nasal lavages during experimental rhinovirus infection in asthmatic and non‐asthmatic subjects

21 January 2018

1 reference

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Enhanced production of biologically active interleukin-1 alpha and interleukin-1 beta by psoriatic epidermal cells ex vivo: evidence of increased cytosolic interleukin-1 beta levels and facilitated interleukin-1 release.

21 January 2018

1 reference

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Developmental pharmacokinetics of morphine and its metabolites in neonates, infants and young children.

21 January 2018

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Effect of interleukin-6 neutralization on CYP3A11 and metallothionein-1/2 expressions in arthritic mouse liver.

21 January 2018

1 reference

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Two-year results from an open-label, multicentre, phase III study evaluating the safety and efficacy of canakinumab in patients with cryopyrin-associated periodic syndrome across different severity phenotypes

21 January 2018

1 reference

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Prevention of experimental autoimmune encephalomyelitis in the common marmoset (Callithrix jacchus) using a chimeric antagonist monoclonal antibody against human CD40 is associated with altered B cell responses

21 January 2018

1 reference

12 December 2020

Rilonacept for the treatment of cryopyrin-associated periodic syndromes (CAPS)

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic modeling of a humanized anti-IL-13 antibody in naive and Ascaris-challenged cynomolgus monkeys

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12 December 2020

Recommendations for the design and optimization of immunoassays used in the detection of host antibodies against biotechnology products

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12 December 2020

Monoclonal antibody pharmacokinetics and pharmacodynamics

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Identifiers

DOI

1 reference

PMCID

3584253

Dimensions Publication ID

15 August 2017

0 references

1 reference

15 August 2017

1 reference

PMCID

3584253