Retinoids cause apoptosis in pancreatic cancer cells via activation of RAR-gamma and altered expression of Bcl-2/Bax (Q36646046)

15 August 2017

Retinoids cause apoptosis in pancreatic cancer cells via activation of RAR-gamma and altered expression of Bcl-2/Bax (English)

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15 August 2017

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F Pettersson

1

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15 August 2017

A G Dalgleish

series ordinal

2

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15 August 2017

R P Bissonnette

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3

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15 August 2017

K W Colston

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4

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15 August 2017

language of work or name

English

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publication date

1 August 2002

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British Journal of Cancer

15 August 2017

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15 August 2017

87

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15 August 2017

5

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15 August 2017

555-561

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https://scigraph.springernature.com/pub.10.1038/sj.bjc.6600496

15 August 2017

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Transient expression of wild-type or mitochondrially targeted Bcl-2 induces apoptosis, whereas transient expression of endoplasmic reticulum-targeted Bcl-2 is protective against Bax-induced cell death

30 September 2017

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Evidence that retinoic acid receptor beta induction by retinoids is important for tumor cell growth inhibition

30 September 2017

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Differential effects of retinoic acid on growth and apoptosis in human colon cancer cell lines associated with the induction of retinoic acid receptor beta

30 September 2017

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The coregulator exchange in transcriptional functions of nuclear receptors

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BCL-2 family members and the mitochondria in apoptosis

30 September 2017

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Standard surgical treatment in pancreatic cancer

30 September 2017

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Current chemotherapeutic possibilities in pancreaticobiliary cancer

30 September 2017

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Apoptosis without caspases: an inefficient molecular guillotine?

30 September 2017

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Increasing the complexity of coactivation in nuclear receptor signaling

30 September 2017

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Retinoic acid receptor gamma1 expression determines retinoid sensitivity in pancreatic carcinoma cells

30 September 2017

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Antiproliferative activity and apoptosis induced by retinoic acid receptor-gamma selectively binding retinoids in neuroblastoma.

30 September 2017

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Modulation of p53, WAF1/p21 and BCL-2 expression during retinoic acid-induced differentiation of NB4 promyelocytic cells

30 September 2017

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Altered sensitivity to retinoid-induced apoptosis associated with changes in the subcellular distribution of Bcl-2.

30 September 2017

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Retinoid X receptor (RXR) within the RXR-retinoic acid receptor heterodimer binds its ligand and enhances retinoid-dependent gene expression

30 September 2017

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Biochemical pathways of retinoid transport, metabolism, and signal transduction

30 September 2017

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Retinoid-regulated expression of BCL-2 and tissue transglutaminase during the differentiation and apoptosis of human myeloid leukemia (HL-60) cells

30 September 2017

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Antiproliferative effects of the arotinoid Ro 40-8757 in human gastrointestinal and pancreatic cancer cell lines: combinations with 5-fluorouracil and interferon-alpha

30 September 2017

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Retinoids and chemoprevention: clinical and basic studies.

30 September 2017

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Retinoids: transport, metabolism, and mechanisms of action

30 September 2017

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Cancer combination chemotherapy with retinoids: experimental rationale

30 September 2017

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30 September 2017

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30 September 2017

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9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

30 September 2017

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Retinoids: effects on growth, differentiation, and nuclear receptor expression in human pancreatic carcinoma cell lines

30 September 2017

1 reference

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Differential and antagonistic effects of 9-cis-retinoic acid and vitamin D analogues on pancreatic cancer cells in vitro

30 September 2017

1 reference

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Overexpression of retinoic acid receptor beta in head and neck squamous cell carcinoma cells increases their sensitivity to retinoid-induced suppression of squamous differentiation by retinoids

28 June 2018

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Specific activation of retinoic acid receptors (RARs) and retinoid X receptors reveals a unique role for RARgamma in induction of differentiation and apoptosis of S91 melanoma cells

28 June 2018

1 reference

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Transactivation properties of retinoic acid and retinoid X receptors in mammalian cells and yeast. Correlation with hormone binding and effects of metabolism

28 June 2018

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Wild-type, mitochondrial and ER-restricted Bcl-2 inhibit DNA damage-induced apoptosis but do not affect death receptor-induced apoptosis.

28 June 2018

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Retinoic acid enhances the cytotoxic effects of gemcitabine and cisplatin in pancreatic adenocarcinoma cells

20 September 2018

1 reference

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Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event

20 September 2018

1 reference

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A phase II pilot trial of 13-cis retinoic acid and interferon-alpha in patients with advanced pancreatic carcinoma.

20 September 2018

1 reference

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A novel retinoic acid receptor-selective retinoid, ALRT1550, has potent antitumor activity against human oral squamous carcinoma xenografts in nude mice.

20 September 2018

1 reference

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Hypermethylation of multiple genes in pancreatic adenocarcinoma

20 September 2018

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12 December 2020

Experimental cancer of the lung.Inhibition by vitamin A of the induction of tracheobronchial squamous metaplasia and squamous cell tumors

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12 December 2020

Expression of retinoic acid receptor beta mediates retinoic acid-induced growth arrest and apoptosis in breast cancer cells

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12 December 2020

Enhancement of HL-60 differentiation by a new class of retinoids with selective activity on retinoid X receptor

1 reference

12 December 2020

All-trans-retinoic acid inhibits growth of human pancreatic cancer cell lines

1 reference

12 December 2020

1 reference

12 December 2020

Retinoic acid receptor beta regulates growth and differentiation in human pancreatic carcinoma cells

1 reference

12 December 2020

Mitochondrial permeability transition and release of cytochrome c induced by retinoic acids

1 reference

12 December 2020

Trends in indications and outcomes in the Whipple procedure over a 40-year period

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.BJC.6600496

1 reference

15 August 2017

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15 August 2017

1 reference