Sphingolipid metabolism, apoptosis and resistance to cytotoxic agents: can we interfere? (Q36648396)

15 August 2017

title

Sphingolipid metabolism, apoptosis and resistance to cytotoxic agents: can we interfere? (English)

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15 August 2017

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Rizzieri KE

1

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15 August 2017

Hannun YA

series ordinal

2

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15 August 2017

publication date

1 January 1998

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15 August 2017

published in

Drug Resistance Updates

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15 August 2017

volume

1

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15 August 2017

issue

6

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15 August 2017

page(s)

359-376

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Genotoxic-stress-response genes and growth-arrest genes. gadd, MyD, and other genes induced by treatments eliciting growth arrest

15 August 2017

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Phospholipase A2 is necessary for tumor necrosis factor alpha-induced ceramide generation in L929 cells

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Role for ceramide in cell cycle arrest.

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Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation

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Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor

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7 January 2021

Involvement of a ceramide activated protein phosphatase in the differentiation of neuroblastoma Neuro2a cells

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7 January 2021

Ceramide induces apoptosis in PC12 cells

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7 January 2021

CD95/Fas-induced ceramide formation proceeds with slow kinetics and is not blocked by caspase-3/CPP32 inhibition

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7 January 2021

Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway

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Regulation of lipid signaling pathways for cell survival and apoptosis by bcl-2 in prostate carcinoma cells

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7 January 2021

Functions of ceramide in coordinating cellular responses to stress

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7 January 2021

Tumour necrosis factor-alpha induces superoxide anion generation in mitochondria of L929 cells

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7 January 2021

TNF alpha alters mitochondrial membrane potential in L929 but not in TNF alpha-resistant L929.12 cells: relationship with the expression of stress proteins, annexin 1 and superoxide dismutase activity

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7 January 2021

Signalling mechanisms and oxidative stress in apoptosis

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7 January 2021

Redox signalling and the control of cell growth and death

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7 January 2021

Small stress proteins as novel regulators of apoptosis. Heat shock protein 27 blocks Fas/APO-1- and staurosporine-induced cell death.

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7 January 2021

Apoptosis or necrosis: intracellular levels of glutathione influence mode of cell death

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7 January 2021

Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis

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7 January 2021

Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration

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7 January 2021

Functions of sphingolipids and sphingolipid breakdown products in cellular regulation

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7 January 2021

The mechanism of action of the nitrosourea anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase.

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7 January 2021

Hypoxia and resistance to hydrogen peroxide confer resistance to tumor necrosis factor in murine L929 cells.

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7 January 2021

Fas-mediated apoptosis is modulated by intracellular glutathione in human T cells

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7 January 2021

Depletion in vitro of mitochondrial glutathione in rat hepatocytes and enhancement of lipid peroxidation by adriamycin and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)

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7 January 2021

The use of 1H spin echo NMR and HPLC to confirm doxorubicin induced depletion of glutathione in the intact HeLa cell

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7 January 2021

The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses

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7 January 2021

The 70-kilodalton heat-shock proteins of the SSA subfamily negatively modulate heat-shock-induced accumulation of trehalose and promote recovery from heat stress in the yeast, Saccharomyces cerevisiae

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7 January 2021

Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae

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7 January 2021

Heat-induced elevation of ceramide in Saccharomyces cerevisiae via de novo synthesis

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7 January 2021

Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation

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7 January 2021

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

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7 January 2021

Fumonisin toxicity and sphingolipid biosynthesis.

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7 January 2021

Signal transduction through lipid second messengers

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7 January 2021

Enzymology of long-chain base synthesis by liver: characterization of serine palmitoyltransferase in rat liver microsomes

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7 January 2021

Metabolism of Sphingosine Bases, VIII. Distribution, Isolation and Properties of D-3-Oxosphinganine Reductase. Stereospecificity of the NADPH-dependent Reduction Reaction of 3-Oxodihydrosphingosine(2-Amino-1-hydroxyoctadecane-3-one)

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7 January 2021

An update of the enzymology and regulation of sphingomyelin metabolism

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7 January 2021

Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum

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7 January 2021

Conversion of dihydroceramide into ceramide: involvement of a desaturase

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7 January 2021

A Novel Enzyme That Cleaves the N-Acyl Linkage of Ceramides in Various Glycosphingolipids as Well as Sphingomyelin to Produce Their Lyso Forms

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7 January 2021

Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses

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7 January 2021

Kinase suppressor of Ras is ceramide-activated protein kinase

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7 January 2021

Phosphorylation of Raf by ceramide-activated protein kinase

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7 January 2021

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid

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7 January 2021

Sphingomyelinases in cell regulation

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7 January 2021

Acid sphingomyelinase from human urine: purification and characterization.

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7 January 2021

Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione

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7 January 2021

Ceramide: an intracellular mediator of apoptosis and growth suppression

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7 January 2021

Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis

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7 January 2021

Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine

1 reference

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7 January 2021

(1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase

1 reference

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7 January 2021

Changing J774A.1 cells to new medium perturbs multiple signaling pathways, including the modulation of protein kinase C by endogenous sphingoid bases

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2898%2980012-5

7 January 2021

Programmed cell death induced by ceramide

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2898%2980012-5

7 January 2021

Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2898%2980012-5

7 January 2021

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

1 reference

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7 January 2021

Direct evidence for an important role of sphingomyelinase in ultraviolet-induced activation of c-Jun N-terminal kinase

1 reference

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7 January 2021

Caspases: intracellular signaling by proteolysis

1 reference

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7 January 2021

Bik and Bak Induce Apoptosis Downstream of CrmA but Upstream of Inhibitor of Apoptosis

1 reference

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7 January 2021

The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis

1 reference

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7 January 2021

Activation of CPP32-like protease in tumor necrosis factor-induced apoptosis is dependent on mitochondrial function

1 reference

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7 January 2021

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

1 reference

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7 January 2021

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

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7 January 2021

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

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7 January 2021

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

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7 January 2021

Cytochrome c: can't live with it--can't live without it.

1 reference

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7 January 2021

Bcl-2 acts upstream of the PARP protease and prevents its activation

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2898%2980012-5

7 January 2021

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

1 reference

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7 January 2021

Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide

1 reference

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7 January 2021

The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transition

1 reference

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7 January 2021

TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2898%2980012-5

7 January 2021

Acidic sphingomyelinase mediates entry of N. gonorrhoeae into nonphagocytic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2898%2980012-5

7 January 2021

CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase.

1 reference

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7 January 2021

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2898%2980012-5

7 January 2021

Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.

1 reference

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7 January 2021

Lymphocyte activation in health and disease

1 reference

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7 January 2021

Dexamethasone increases neutral sphingomyelinase activity and sphingosine levels in 3T3-L1 fibroblasts

1 reference

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7 January 2021

Protein kinase CbetaII activation by 1-beta-D-arabinofuranosylcytosine is antagonistic to stimulation of apoptosis and Bcl-2alpha down-regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2898%2980012-5

7 January 2021

Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis

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https://api.crossref.org/works/10.1016%2FS1368-7646%2898%2980012-5

7 January 2021

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

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https://api.crossref.org/works/10.1016%2FS1368-7646%2898%2980012-5

7 January 2021

P-glycoprotein expression in the Golgi apparatus of multidrug-resistant cells.

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https://api.crossref.org/works/10.1016%2FS1368-7646%2898%2980012-5

7 January 2021

Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis.

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7 January 2021

Accumulation of glucosylceramides in multidrug-resistant cancer cells

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7 January 2021

Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2898%2980012-5

7 January 2021

Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24 kDa apoptotic protease (AP24).

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2898%2980012-5

7 January 2021

Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2898%2980012-5

7 January 2021

1H NMR ganglioside ceramide resonance region on the differential diagnosis of low and high malignancy of brain gliomas

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https://api.crossref.org/works/10.1016%2FS1368-7646%2898%2980012-5

7 January 2021

Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines

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https://api.crossref.org/works/10.1016%2FS1368-7646%2898%2980012-5

7 January 2021

A possible role of sphingosine in induction of apoptosis by tumor necrosis factor-alpha in human neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2898%2980012-5

7 January 2021

Induction of apoptosis and potentiation of TNF- and Fas-mediated apoptosis in U937 cells by the xanthogenate compound D609

1 reference

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7 January 2021

Ultrastructural changes in the Golgi apparatus and secretory granules of HL-60 cells treated with the imino sugar N-butyldeoxynojirimycin

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2898%2980012-5

7 January 2021

Induction of glucosylceramide synthase by synthase inhibitors and ceramide

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7 January 2021

Glucosphingolipids as sites of action in the chemotherapy of cancer

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7 January 2021

Antitumor activity via inhibition of glycosphingolipid biosynthesis.

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7 January 2021

Synthesis and antiproliferative activity of cytidine-5'-alkylphosphonophosphates and structurally related compounds.

1 reference

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7 January 2021

Analogs of alkyllysophospholipids: Chemistry, effects on the molecular level and their consequences for normal and malignant cells

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7 January 2021

New nucleoside-5'-alkylphosphonophosphates and related compounds containing 2'-deoxycytidine, thymidine and adenosine as nucleoside component. Syntheses and their effects on tumor cell growth in vitro.

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7 January 2021

10.1016/S1368-7646(98)80012-5

Identifiers

DOI

1 reference

15 August 2017

1 reference