Molecular basis of the glomerular filtration: nephrin and the emerging protein complex at the podocyte slit diaphragm (Q36652540)

15 August 2017

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title

Molecular basis of the glomerular filtration: nephrin and the emerging protein complex at the podocyte slit diaphragm (English)

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15 August 2017

Anu Pätäri-Sampo

1

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15 August 2017

Pekka Ihalmo

series ordinal

2

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15 August 2017

Harry Holthöfer

series ordinal

3

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15 August 2017

language of work or name

English

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publication date

1 January 2006

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15 August 2017

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15 August 2017

volume

38

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15 August 2017

issue

7

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15 August 2017

page(s)

483-492

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Porous substructure of the glomerular slit diaphragm in the rat and mouse

15 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Stability and leakiness: opposing challenges to the glomerulus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Renal papillary necrosis induced by naproxen

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Recent advances in congenital nephrotic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Structure of the gene for congenital nephrotic syndrome of the finnish type (NPHS1) and characterization of mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Mutation spectrum in the nephrin gene (NPHS1) in congenital nephrotic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Proteinuria and prenatal diagnosis of congenital nephrosis in fetal carriers of nephrin gene mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Determinants of vascular permeability in the kidney glomerulus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Nephrin localizes at the podocyte filtration slit area and is characteristically spliced in the human kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Nephrin is specifically located at the slit diaphragm of glomerular podocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

The molecular structure of cell adhesion molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Nephrin and Neph1 co-localize at the podocyte foot process intercellular junction and form cis hetero-oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Nephrin promotes cell-cell adhesion through homophilic interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Cloning and expression of the rat nephrin homolog.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Nephritogenic mAb 5-1-6 is directed at the extracellular domain of rat nephrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Nephrin localizes to the slit pore of the glomerular epithelial cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

N-linked glycosylation is critical for the plasma membrane localization of nephrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Alternative splicing of the mRNA coding for the human endothelial angiotensin-converting enzyme: a new mechanism for solubilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Molecular cloning and characterization of an endogenous antisense transcript of Nphs1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Involvement of lipid rafts in nephrin phosphorylation and organization of the glomerular slit diaphragm

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Cloning of rat nephrin: expression in developing glomeruli and in proteinuric states

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Recurrence of nephrotic syndrome after transplantation in CNF is due to autoantibodies to nephrin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Recurrence of nephrotic syndrome in kidney grafts of patients with congenital nephrotic syndrome of the Finnish type: role of nephrin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Vascular endothelial growth factor and nephrin interact and reduce apoptosis in human podocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

VEGF and the quest for tumour angiogenesis factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Inflammatory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

PPARalpha activation upregulates nephrin expression in human embryonic kidney epithelial cells and podocytes by a dual mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Pioglitazone reduces urinary podocyte excretion in type 2 diabetes patients with microalbuminuria

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Filtrin is a novel member of nephrin-like proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Actin Filament Organization of Foot Processes in Rat Podocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Comparative promoter analysis allows de novo identification of specialized cell junction-associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Genetic dissection of cadherin function during nephrogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Precocious mammary gland development in P-cadherin-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Hypotrichosis with juvenile macular dystrophy is caused by a mutation in CDH3, encoding P-cadherin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

A novel protein, densin, expressed by glomerular podocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Interaction of endogenous nephrin and CD2-associated protein in mouse epithelial M-1 cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

CD2-associated protein directly interacts with the actin cytoskeleton.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Podocyte slit-diaphragm protein nephrin is linked to the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Genotype/phenotype correlations of NPHS1 and NPHS2 mutations in nephrotic syndrome advocate a functional inter-relationship in glomerular filtration

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Early glomerular filtration defect and severe renal disease in podocin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Podocin localizes in the kidney to the slit diaphragm area

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Interaction with podocin facilitates nephrin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

SRC-family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Disease-causing missense mutations in NPHS2 gene alter normal nephrin trafficking to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Diversity among tight junctions in rat kidney: glomerular slit diaphragms and endothelial junctions express only one isoform of the tight junction protein ZO-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

The tight junction protein ZO-1 is concentrated along slit diaphragms of the glomerular epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Transmembrane proteins of tight junctions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

A quantitative immunofluorescence study of glomerular cell adhesion proteins in proteinuric states

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

Neutralization of Circulating Vascular Endothelial Growth Factor (VEGF) by Anti-VEGF Antibodies and Soluble VEGF Receptor 1 (sFlt-1) Induces Proteinuria

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07853890600978149

10.1080/07853890600978149

21 January 2018

Identifiers

DOI

1 reference

15 August 2017

1 reference