Mechanisms of Disease: astrocytes in neurodegenerative disease (Q36658874)

15 August 2017

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title

Mechanisms of Disease: astrocytes in neurodegenerative disease (English)

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15 August 2017

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Nicholas J Maragakis

1

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PubMed ID

17117171

15 August 2017

Jeffrey D Rothstein

series ordinal

2

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15 August 2017

1 December 2006

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Nature Clinical Practice Neurology

15 August 2017

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15 August 2017

2

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15 August 2017

12

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15 August 2017

679-689

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https://api.crossref.org/works/10.1038%2FNCPNEURO0355

15 August 2017

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7 January 2021

Potassium buffering in the central nervous system

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

A multi-photon window onto neuronal-glial-vascular communication

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Astrocyte-mediated control of cerebral blood flow

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Glutamate transporters in glial plasma membranes: highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Expression of the glial glutamate transporter EAAT2 in the human CNS: an immunohistochemical study

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Localization of neuronal and glial glutamate transporters

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

GLIA: listening and talking to the synapse

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Functional hemichannels in astrocytes: a novel mechanism of glutamate release.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

The neurobiology of glia in the context of water and ion homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Astrocytic intermediate filaments: lessons from GFAP and vimentin knock-out mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Absence of glial fibrillary acidic protein and vimentin prevents hypertrophy of astrocytic processes and improves post-traumatic regeneration.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Functional changes of glial glutamate transporter GLT-1 during ischemia: an in vivo study in the hippocampal CA1 of normal mice and mutant mice lacking GLT-1.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Amygdala-kindled and pentylenetetrazole-induced seizures in glutamate transporter GLAST-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

A polymorphism in the EAAT2 promoter is associated with higher glutamate concentrations and higher frequency of progressing stroke

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Reactive astrocytes in neural repair and protection

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Gap junctions between cultured astrocytes: immunocytochemical, molecular, and electrophysiological analysis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Cardiac malformation in neonatal mice lacking connexin43.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Connexin43 null mutation increases infarct size after stroke

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Amyotrophic lateral sclerosis: pathogenesis, differential diagnoses, and potential interventions.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

The RNA of the glutamate transporter EAAT2 is variably spliced in amyotrophic lateral sclerosis and normal individuals

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Intron 7 retention and exon 9 skipping EAAT2 mRNA variants are not associated with amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS).

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Alzheimer's disease: genes, proteins, and therapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Spatial relationships between astrocytes and classical plaque components

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Alzheimer's amyloid beta-peptide enhances ATP/gap junction-mediated calcium-wave propagation in astrocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Calcium oscillations in type-1 astrocytes, the effect of a presenilin 1 (PS1) mutation

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Tau-positive glial inclusions in progressive supranuclear palsy, corticobasal degeneration and Pick's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Impaired glutamate transport in a mouse model of tau pathology in astrocytes.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Huntingtin protein colocalizes with lesions of neurodegenerative diseases: An investigation in Huntington's, Alzheimer's, and Pick's diseases

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Changes of NMDA receptor subunit (NR1, NR2B) and glutamate transporter (GLT1) mRNA expression in Huntington's disease--an in situ hybridization study.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Connexin expression in Huntington's diseased human brain

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Impaired glutamate uptake in the R6 Huntington's disease transgenic mice.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Clinical practice. Diagnosis and initial management of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Glutathione peroxidase, glial cells and Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

NACP/alpha-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brains

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Cellular pathology of Parkinson's disease: astrocytes, microglia and inflammation

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Intranigral infusion of interleukin-1beta activates astrocytes and protects from subsequent 6-hydroxydopamine neurotoxicity.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Neurodegeneration or neuroprotection: the pivotal role of astrocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Glutamate transporters: animal models to neurologic disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Glial fibrillary acidic protein mutations in infantile, juvenile, and adult forms of Alexander disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0355

7 January 2021

Identifiers

DOI

10.1038/NCPNEURO0355

1 reference

15 August 2017

1 reference

PubMed ID

17117171