Mechanisms of Disease: the role of immune cells in the pathogenesis of systemic sclerosis (Q36667816)

15 August 2017

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title

Mechanisms of Disease: the role of immune cells in the pathogenesis of systemic sclerosis (English)

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15 August 2017

3

Chris D Platsoucas

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15 August 2017

1

Lazaros I Sakkas

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15 August 2017

Ian C Chikanza

2

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15 August 2017

1 December 2006

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Nature Clinical Practice Rheumatology

15 August 2017

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15 August 2017

2

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15 August 2017

12

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15 August 2017

679-685

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Is systemic sclerosis an antigen-driven T cell disease?

15 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Scleroderma: from cell and molecular mechanisms to disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Early T cell activation in the skin from patients with systemic sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Systemic and cell type-specific gene expression patterns in scleroderma skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

In vivo analysis of the apoptosis-inducing effect of anti-endothelial cell antibodies in systemic sclerosis by the chorionallantoic membrane assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Altered blood B lymphocyte homeostasis in systemic sclerosis: expanded naive B cells and diminished but activated memory B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Prognostic significance of anticentromere antibodies and anti-topoisomerase I antibodies in Raynaud's disease. A prospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Regressive systemic sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

The transforming growth factor-beta family

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Augmented production of transforming growth factor-beta by cultured peripheral blood mononuclear cells from patients with systemic sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Stimulation of collagen and glycosaminoglycan production in cultured human adult dermal fibroblasts by recombinant human interleukin 6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Autoantibodies to fibrillin-1 activate normal human fibroblasts in culture through the TGF-beta pathway to recapitulate the "scleroderma phenotype".

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

IgG antiendothelial cell autoantibodies from scleroderma patients induce leukocyte adhesion to human vascular endothelial cells in vitro. Induction of adhesion molecule expression and involvement of endothelium-derived cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Novel fibrogenic pathways are activated in response to endothelial apoptosis: implications in the pathophysiology of systemic sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Costimulation of fibroblast collagen and transforming growth factor beta1 gene expression by monocyte chemoattractant protein-1 via specific receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Monocyte chemoattractant protein 1 released from glycosaminoglycans mediates its profibrotic effects in systemic sclerosis via the release of interleukin-4 from T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Blockade of CCR2 ameliorates progressive fibrosis in kidney.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Endogenous IL-1alpha from systemic sclerosis fibroblasts induces IL-6 and PDGF-A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

The antiangiogenic tissue kallikrein pattern of endothelial cells in systemic sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Identification of fetal DNA and cells in skin lesions from women with systemic sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Mapping of the immunodominant T cell epitopes of the protein topoisomerase I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Systemic sclerosis: hypothesis-driven treatment strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Cyclophosphamide versus placebo in scleroderma lung disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Pilot study of anti-thymocyte globulin plus mycophenolate mofetil in recent-onset diffuse scleroderma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Mycophenolate mofetil as first-line treatment improves clinically evident early scleroderma lung disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Targeting activated T cells: successful use of anti-CD25 monoclonal antibody basiliximab in a patient with systemic sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Intravenous immunoglobulin modulates cutaneous involvement and reduces skin fibrosis in systemic sclerosis: an open-label study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

Sequential dermal microvascular and perivascular changes in the development of scleroderma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

7 January 2021

Stimulatory Autoantibodies to the PDGF Receptor in Systemic Sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

7 January 2021

Abnormal expression of intracellular cytokines and chemokine receptors in peripheral blood T lymphocytes from patients with systemic sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

7 January 2021

Increased interleukin-17 production in patients with systemic sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

7 January 2021

Blockade of endogenous transforming growth factor beta signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: association with increased expression of transforming growth factor beta receptors

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

7 January 2021

Increased CD40 expression in skin fibroblasts from patients with systemic sclerosis (SSc): role of CD40‐CD154 in the phenotype of SSc fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

7 January 2021

Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

7 January 2021

Autoantibody against matrix metalloproteinase-3 in patients with systemic sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

7 January 2021

Endothelin-1 regulation of intercellular adhesion molecule-1 expression in normal and sclerodermal fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

7 January 2021

Defective vasculogenesis in systemic sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

7 January 2021

DNA topoisomerase I binding to fibroblasts induces monocyte adhesion and activation in the presence of anti-topoisomerase I autoantibodies from systemic sclerosis patients

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

7 January 2021

Oligoclonal T cell expansion in the skin of patients with systemic sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

7 January 2021

Th2-oriented profile of male offspring T cells present in women with systemic sclerosis and reactive with maternal major histocompatibility complex antigens

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

7 January 2021

Peripheral T lymphocytes from patients with early systemic sclerosis co-cultured with autologous fibroblasts undergo an oligoclonal expansion similar to that occurring in the skin

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

7 January 2021

Treatment of chronic graft-versus-host disease with anti-CD20 chimeric monoclonal antibody

1 reference

https://api.crossref.org/works/10.1038%2FNCPRHEUM0346

7 January 2021

Identifiers

DOI

10.1038/NCPRHEUM0346

1 reference

15 August 2017

1 reference

PubMed ID

17133253