The ubiquitous gp63-like metalloprotease from lower trypanosomatids: in the search for a function (Q36672756)

15 August 2017

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title

The ubiquitous gp63-like metalloprotease from lower trypanosomatids: in the search for a function (English)

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15 August 2017

trypanosomatids

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2

Marta H Branquinha

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PubMed ID

17143406

André Luis Souza Dos Santos

15 August 2017

series ordinal

1

object named as

André L S Santos

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15 August 2017

Claudia M D'Avila-Levy

series ordinal

3

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15 August 2017

1 December 2006

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Anais da Academia Brasileira de Ciências

15 August 2017

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15 August 2017

78

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15 August 2017

4

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15 August 2017

687-714

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Expression of lipophosphoglycan, high-molecular weight phosphoglycan and glycoprotein 63 in promastigotes and amastigotes of Leishmania mexicana

15 August 2017

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

In vitro cytocidal effects on Trypanosoma brucei and inhibition of Leishmania major GP63 by peptidomimetic metalloprotease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

The MEROPS database as a protease information system

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Managing peptidases in the genomic era.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Structural basis of the matrix metalloproteinases and their physiological inhibitors, the tissue inhibitors of metalloproteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Leishmania and Trypanosoma surface glycoproteins have a common glycophospholipid membrane anchor

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Characterization of the promastigote surface protease of Leishmania as a membrane-bound zinc endopeptidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Peptide substrate specificity of the membrane-bound metalloprotease of Leishmania

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

The heterogeneity of choanomastigote-shaped trypanosomatids as analyzed by their kDNA minicircle size: taxonomic implicaitons

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Ubiquity of cysteine- and metalloproteinase activities in a wide range of trypanosomatids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Molecular cloning of the major surface antigen of leishmania

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Genes encoding the major surface glycoprotein in Leishmania are tandemly linked at a single chromosomal locus and are constitutively transcribed

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

The major cysteine proteinase of Trypanosoma cruzi: a valid target for chemotherapy of Chagas disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Monoclonal antibody affinity purification of a Leishmania membrane glycoprotein and its inhibition of leishmania-macrophage binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Expression and size heterogeneity of a 63 kilodalton membrane glycoprotein during growth and transformation of Leishmania mexicana amazonensis

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Heme biosynthesis in bacterium-protozoon symbioses: enzymic defects in host hemoflagellates and complemental role of their intracellular symbiotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Acid protease activity of a major surface membrane glycoprotein (gp63) from Leishmania mexicana promastigotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Lower trypanosomatids in HIV/AIDS patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

gp63 homologues in Trypanosoma cruzi: surface antigens with metalloprotease activity and a possible role in host cell infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

A Revised Classification for Leishmania and Endotrypanum

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Expression of LPG and GP63 by different developmental stages of Leishmania major in the sandfly Phlebotomus papatasi

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Differential expression of proteolytic enzymes in endosymbiont-harboring Crithidia species

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

A metalloproteinase extracellularly released by Crithidia deanei.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Differential lectin recognition of glycoproteins in choanomastigote-shaped trypanosomatids: taxonomic implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Proteolytic expression in Blastocrithidia culicis: influence of the endosymbiont and similarities with virulence factors of pathogenic trypanosomatids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Influence of the endosymbiont of Blastocrithidia culicis and Crithidia deanei on the glycoconjugate expression and on Aedes aegypti interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Insights into the role of gp63-like proteins in lower trypanosomatids

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Gp63-like molecules in Phytomonas serpens: possible role in the insect interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Structural organization of the cell surface of pathogenic protozoa

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Endosymbiosis in protozoa of the Trypanosomatidae family

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Glycoconjugates in Leishmania infectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Trypanosomatid prevalence and host habitat choice in woodland Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Leishmanolysin (gp63 metallopeptidase)-like activity extracellularly released by Herpetomonas samuelpessoai

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Identification of a surface metalloproteinase on 13 species of Leishmania isolated from humans, Crithidia fasciculata, and Herpetomonas samuelpessoai

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Interaction of insect trypanosomatids with mosquitoes, sand fly and the respective insect cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Surface antigenic change during differentiation of a parasitic protozoan, Leishmania mexicana: Identification by monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Epitope cleavage by Leishmania endopeptidase(s) limits the efficiency of the exogenous pathway of major histocompatibility complex class I-associated antigen presentation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

The changing epidemiology of yellow fever and dengue, 1900 to 2003: full circle?

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Down-regulation of gp63 in Leishmania amazonensis reduces its early development in Lutzomyia longipalpis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Molecular phylogenetics of Trypanosomatidae: contrasting results from 18S rRNA and protein phylogenies

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Function and assembly of the Leishmania surface coat

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Crithidia fasciculata contains a transcribed leishmanial surface proteinase (gp63) gene homologue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Extracellular release of the surface metalloprotease, gp63, from Leishmania and insect trypanosomatids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

HIV co-infection with a currently non-pathogenic flagellate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Targeted gene deletion in Leishmania major identifies leishmanolysin (GP63) as a virulence factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Expression and Function of the Trypanosoma brucei Major Surface Protease (GP63) Genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Signal transduction by a protease cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Analysis of the active site and activation mechanism of the Leishmania surface metalloproteinase GP63.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Leishmania infection and virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Extracellular release of the glycosylphosphatidylinositol (GPI)-linked Leishmania surface metalloprotease, gp63, is independent of GPI phospholipolysis: implications for parasite virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Migration through the extracellular matrix by the parasitic protozoan Leishmania is enhanced by surface metalloprotease gp63.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Development of cysteine protease inhibitors as chemotherapy for parasitic diseases: insights on safety, target validation, and mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

The proteases and pathogenicity of parasitic protozoa

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

The promastigote surface protease (gp63) of Leishmania is expressed but differentially processed and localized in the amastigote stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Structurally distinct genes for the surface protease of Leishmania mexicana are developmentally regulated.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Microbial metalloproteases and pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Some current problems in the systematics of Trypanosomatids

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Membrane-bound peptidases: endocrine, paracrine, and autocrine effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Crithidia guilhermei: purification and partial characterization of a 62-kDa extracellular metalloproteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Crithidia guilhermei: gelatin- and haemoglobin-degrading extracellular metalloproteinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Peptidases and gp63-like proteins in Herpetomonas megaseliae: possible involvement in the adhesion to the invertebrate host.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

The more insect trypanosomatids under study-the more diverse Trypanosomatidae appears

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

MEROPS: the protease database

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

MEROPS: the peptidase database.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Evolutionary families of peptidase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Ultrastructural and biochemical characterization of promastigote and cystic forms of Leptomonas wallacei n. sp. isolated from the intestine of its natural host Oncopeltus fasciatus (Hemiptera: Lygaeidae).

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Cysteine proteases of parasitic organisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Cell-associated and extracellular proteinases in Blastocrithidia culicis: influence of growth conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Developmentally regulated protein expression mediated by dimethylsulfoxide in Herpetomonas samuelpessoai

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Changes of sialomolecules during the dimethylsulfoxide-induced differentiation of Herpetomonas samuelpessoai

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Herpetomonas samuelpessoai: dimethylsulfoxide-induced differentiation is influenced by proteinase expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Use of proteolytic enzymes as an additional tool for trypanosomatid identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Phytomonas serpens: cysteine peptidase inhibitors interfere with growth, ultrastructure and host adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

The crystal structure of the Leishmania major surface proteinase leishmanolysin (gp63)

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Characterization of a surface metalloprotease from Herpetomonas samuelpessoai and comparison with Leishmania major promastigote surface protease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Leishmania major: differential regulation of the surface metalloprotease in amastigote and promastigote stages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Pseudallescheria boydii releases metallopeptidases capable of cleaving several proteinaceous compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Leishmania (Leishmania) amazonensis: differential expression of proteinases and cell-surface polypeptides in avirulent and virulent promastigotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Mechanism of acquired immunity induced by "Leptomonas pessoai" against Trypanosoma cruzi in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

A new expression vector for Crithidia fasciculata and Leishmania

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Extracellular metalloproteinases in Phytomonas serpens

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

The evolutionary expansion of the trypanosomatid flagellates

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

The trypanosomatid parasites of insects and arachnids

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Proteases as biological regulators. Introductory remarks

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Biosynthesis of the major surface protease GP63 of Leishmania chagasi

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

The major surface protease (MSP or GP63) of Leishmania sp. Biosynthesis, regulation of expression, and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

The third component of complement (C3) is responsible for the intracellular survival of Leishmania major

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

Infection of Mouse Dermal Fibroblasts by the Monoxenous Trypanosomatid Protozoa Crithidia deanei and Herpetomonas roitmani

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0001-37652006000400006

10.1590/S0001-37652006000400006

21 January 2018

Identifiers

DOI

1 reference

15 August 2017

1 reference

PubMed ID

17143406