Interleukin-18 as a potential therapeutic target in chronic autoimmune/inflammatory conditions (Q36675441)

15 August 2017

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title

Interleukin-18 as a potential therapeutic target in chronic autoimmune/inflammatory conditions (English)

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15 August 2017

Costantino Pitzalis

3

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Iain McInnes

object named as

Iain B McInnes

series ordinal

2

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Michele Bombardieri

series ordinal

1

object named as

Michele Bombardieri

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15 August 2017

language of work or name

English

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publication date

1 January 2007

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Expert Opinion on Biological Therapy

15 August 2017

published in

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15 August 2017

volume

7

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15 August 2017

issue

1

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15 August 2017

page(s)

31-40

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Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells

15 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Targeting interleukin 18 with interleukin 18 binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Defective NK cell activity and Th1 response in IL-18-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Regulation of interferon-gamma production by IL-12 and IL-18.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Interleukin-18 regulates both Th1 and Th2 responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

A proinflammatory role for IL-18 in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Interleukin 18: a pleiotropic participant in chronic inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Prostaglandin E(2) inhibits IL-18-induced ICAM-1 and B7.2 expression through EP2/EP4 receptors in human peripheral blood mononuclear cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Interferon-gamma-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Expression of interleukin-18 receptor in fibroblast-like synoviocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

IL-18-induced CD83+CCR7+ NK helper cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Interferon-gamma-inducing activity of interleukin-18 in the joint with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Interleukin-18 induces rheumatoid arthritis synovial fibroblast CXC chemokine production through NFkappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Interleukin-18 induces the production of vascular endothelial growth factor (VEGF) in rheumatoid arthritis synovial fibroblasts via AP-1-dependent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Anti-tumour necrosis factor (TNF) alpha treatment of rheumatoid arthritis (infliximab) selectively down regulates the production of interleukin (IL) 18 but not of IL12 and IL13.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Clinical efficacy of infliximab plus methotrexate in DMARD naive and DMARD refractory rheumatoid arthritis is associated with decreased synovial expression of TNF alpha and IL18 but not CXCL12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Evidence of IL-18 as a novel angiogenic mediator

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Cardiovascular disease in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Vascular comorbidity in rheumatoid arthritis: potential mechanisms and solutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Interleukin-18 enhances atherosclerosis in apolipoprotein E(-/-) mice through release of interferon-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Combined Effects of IL-12 and IL-18 on the Induction of Collagen-Induced Arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Reduced Incidence and Severity of Collagen-Induced Arthritis in Mice Lacking IL-18

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Adenoviral delivery of IL-18 binding protein C ameliorates collagen-induced arthritis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

IL18 polymorphism is associated with an increased risk of Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Association of polymorphisms in the interleukin-18 gene in patients with Crohn's disease depending on the CARD15/NOD2 genotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-alpha production in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Commentary: the role of the IL-18 system and other members of the IL-1R/TLR superfamily in innate mucosal immunity and the pathogenesis of inflammatory bowel disease: friend or foe?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

A Proinflammatory Role of IL-18 in the Development of Spontaneous Autoimmune Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Expression of the matrix receptor CD44v5 on chondrocytes changes with osteoarthritis: an experimental investigation in the rabbit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Association between adult-onset Still's disease and interleukin-18 gene polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Human dendritic cells express the IL-18R and are chemoattracted to IL-18.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Synovial tissue interleukin-18 expression and the response to treatment in patients with inflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Detailed analysis of the cell infiltrate and the expression of mediators of synovial inflammation and joint destruction in the synovium of patients with psoriatic arthritis: implications for treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Interleukin-18 and host defense against infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Interleukins 18 and 21: biology, mechanisms of action, toxicity, and clinical activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Adenovirus-mediated interleukin-18 mutant in vivo gene transfer inhibits tumor growth through the induction of T cell immunity and activation of natural killer cell cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

NK/iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the DC maturation factor HMGB1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Expression of Interleukin-18 in Human Atherosclerotic Plaques and Relation to Plaque Instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Interleukin-18/Interleukin-18 Binding Protein Signaling Modulates Atherosclerotic Lesion Development and Stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

Expression of interleukin‐18 and its monokine‐directed function in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.1.31

21 January 2018

Identifiers

DOI

10.1517/14712598.7.1.31

1 reference

15 August 2017

1 reference