Anti-influenza virus agents: synthesis and mode of action (Q36679637)

15 August 2017

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23 October 2022

Anti-influenza virus agents: synthesis and mode of action (English)

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15 August 2017

Erik De Clercq

2

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author name string

Irene M Lagoja

series ordinal

1

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15 August 2017

publication date

1 January 2008

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Medicinal Research Reviews

15 August 2017

23 October 2022

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15 August 2017

23 October 2022

28

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15 August 2017

issue

1

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15 August 2017

page(s)

1-38

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Approaches and strategies for the treatment of influenza virus infections

15 August 2017

cites work

1 reference

Antiviral agents in influenza--summary of Influenza Workshop VIII.

21 January 2018

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A prospective double-blind study of side effects associated with the administration of amantadine for influenza A virus prophylaxis

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Growth impairment resulting from expression of influenza virus M2 protein in Saccharomyces cerevisiae: identification of a novel inhibitor of influenza virus

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Influenza viruses, cell enzymes, and pathogenicity

21 January 2018

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Inhibition of influenza virus sialidase and anti-influenza virus activity by plant flavonoids

21 January 2018

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Inhibition of influenza virus transcription by 2'-deoxy-2'-fluoroguanosine

21 January 2018

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In vitro anti-influenza virus activity of the pavine alkaloid (-)-thalimonine isolated from Thalictrum simplex L.

21 January 2018

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Evaluation of the anti-influenza virus activities of 1,3,4-thiadiazol-2-ylcyanamide (LY217896) and its sodium salt

21 January 2018

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Oral LY217896 for prevention of experimental influenza A virus infection and illness in humans

21 January 2018

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Oral ribavirin treatment of influenza A and B.

21 January 2018

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Biochemistry and clinical applications of ribavirin

21 January 2018

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Neuraminidase inhibitors as anti-influenza virus agents

21 January 2018

1 reference

Stereospecific synthesis of a GS 4104 metabolite: determination of absolute stereochemistry and influenza neuraminidase inhibitory activity

21 January 2018

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12 December 2020

Enantioselective synthesis of antiinfluenza compound A-315675.

1 reference

12 December 2020

Basis for the potent inhibition of influenza virus infection by equine and guinea pig alpha 2-macroglobulin

1 reference

12 December 2020

Synthesis and anti-influenza evaluation of orally active bicyclic ether derivatives related to zanamivir

1 reference

12 December 2020

Sequence requirements for cleavage activation of influenza virus hemagglutinin expressed in mammalian cells

1 reference

12 December 2020

The molecular biology of influenza virus pathogenicity

1 reference

12 December 2020

Inhibition of the fusion-inducing conformational change of influenza hemagglutinin by benzoquinones and hydroquinones

1 reference

12 December 2020

Synthesis and anti-influenza evaluation of polyvalent sialidase inhibitors bearing 4-guanidino-Neu5Ac2en derivatives

1 reference

12 December 2020

Resistance of mice to reinfection after E-aminocaproic acid treatment of primary influenza virus infection

1 reference

12 December 2020

Mechanism of uncoating of influenza B virus in MDCK cells: action of chloroquine

1 reference

12 December 2020

Mechanism of action of T-705 against influenza virus

1 reference

12 December 2020

The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus.

1 reference

12 December 2020

Antimicrobial peptides and proteins in the innate defense of the airway surface

1 reference

12 December 2020

Synthesis of 2-substituted (+/-)-(2r,3r,5r)-tetrahydrofuran-3,5-dicarboxylic acid derivatives

1 reference

12 December 2020

Protection against lethal influenza virus challenge by RNA interference in vivo.

1 reference

12 December 2020

A system of protein target sequences for anti-RNA-viral chemotherapy by a vitamin B6-Derived zinc-Chelating trioxa-adamantane-triol

1 reference

12 December 2020

Synthesis of 4-azido-4-deoxy-Neu5,7,8,9Ac42en1Me. A key intermediate for the synthesis of GG167 from D-glucono-delta-lactone

1 reference

12 December 2020

Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin

1 reference

12 December 2020

Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides

1 reference

12 December 2020

N-Acetyl-6-sulfo-d-glucosamine as a promising mimic of N-Acetyl neuraminic acid

1 reference

12 December 2020

Transition Metal Catalyzed Synthesis of Arylamines and Aryl Ethers from Aryl Halides and Triflates: Scope and Mechanism

1 reference

12 December 2020

Synthesis of a new stable conformationally constrained 2,7-anhydrosialic acid derivative

1 reference

12 December 2020

Neuraminidase inhibitors for influenza

1 reference

12 December 2020

Synthesis of the sialidase inhibitor siastatin B

1 reference

12 December 2020

Purine 2'-deoxy-2'-fluororibosides as antiinfluenza virus agents

1 reference

12 December 2020

Total synthesis of A-315675: a potent inhibitor of influenza neuraminidase

1 reference

12 December 2020

A novel class of potent influenza virus inhibitors: polysubstituted acylthiourea and its fused heterocycle derivatives

1 reference

12 December 2020

The synthesis of 2,3-didehydro-2,4-dideoxy-4-guanidinyl-N-acetylneuraminic acid: a potent influenza virus sialidase inhibitor

1 reference

12 December 2020

Molecule of the month: oseltamivir phosphate (Tamiflu)

1 reference

12 December 2020

Characterization of inhibition of M2 ion channel activity by BL-1743, an inhibitor of influenza A virus

1 reference

12 December 2020

Structures of aromatic inhibitors of influenza virus neuraminidase

1 reference

12 December 2020

Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization

1 reference

12 December 2020

A new modified DNA enzyme that targets influenza virus A mRNA inhibits viral infection in cultured cells

1 reference

12 December 2020

Structure-activity relationships for a series of thiobenzamide influenza fusion inhibitors derived from 1,3,3-trimethyl-5-hydroxy-cyclohexylmethylamine

1 reference

12 December 2020

Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core.

1 reference

12 December 2020

Novel alpha- and beta-amino acid inhibitors of influenza virus neuraminidase

1 reference

12 December 2020

Antiviral therapy with small particle aerosols

1 reference

12 December 2020

Mechanism of binding of surfactant protein D to influenza A viruses: importance of binding to haemagglutinin to antiviral activity.

1 reference

12 December 2020

Anti-influenza drugs and neuraminidase inhibitors

1 reference

12 December 2020

Antisense oligonucleotides directed against the viral RNA polymerase gene enhance survival of mice infected with influenza A.

1 reference

12 December 2020

Ligand recognition by influenza virus. The binding of bivalent sialosides

1 reference

12 December 2020

Antiviral therapy for influenza : a clinical and economic comparative review

1 reference

12 December 2020

Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including H5N1 avian influenza.

1 reference

12 December 2020

Prophylaxis and treatment of influenza virus infection.

1 reference

12 December 2020

Natural Product Origins of Hsp90 Inhibitors

1 reference

12 December 2020

Syntheses and neuraminidase inhibitory activity of multisubstituted cyclopentane amide derivatives

1 reference

12 December 2020

An approach to the identification of potent inhibitors of influenza virus fusion using parallel synthesis methodology

1 reference

12 December 2020

Hydrophobic benzoic acids as inhibitors of influenza neuraminidase

1 reference

12 December 2020

Heterocyclic rimantadine analogues with antiviral activity

1 reference

12 December 2020

Novel 3-(2-adamantyl)pyrrolidines with potent activity against influenza A virus-identification of aminoadamantane derivatives bearing two pharmacophoric amine groups

1 reference

12 December 2020

The role of antivirals in the control of influenza.

1 reference

12 December 2020

Anti-influenza virus activity of peramivir in mice with single intramuscular injection

1 reference

12 December 2020

Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6

1 reference

12 December 2020

Oral administration of cyclopentane neuraminidase inhibitors protects ferrets against influenza virus infection

1 reference

12 December 2020

Synthesis of 2'-(4-methylumbelliferyl)-.alpha.-D-N-acetylneuraminic acid and detection of skin fibroblast neuraminidase in normal humans and in sialidosis

1 reference

12 December 2020

Inhibition of influenza virus production in virus-infected mice by RNA interference

1 reference

12 December 2020

The human mucus protease inhibitor and its mutants are novel defensive compounds against infection with influenza A and Sendai viruses

1 reference

12 December 2020

Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores

1 reference

12 December 2020

Comparison of the anti-influenza virus activity of cyclopentane derivatives with oseltamivir and zanamivir in vivo

1 reference

12 December 2020

Structure-based characterization and optimization of novel hydrophobic binding interactions in a series of pyrrolidine influenza neuraminidase inhibitors

1 reference

12 December 2020

A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection

1 reference

12 December 2020

Targets of anti-influenza chemotherapy other than neuraminidase and proton pump.

1 reference

12 December 2020

Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque

1 reference

12 December 2020

Aromatic sialic acid analogues as potential inhibitors of influenza virus neuraminidase

1 reference

12 December 2020

Enhancement of the infectivity of influenza A and B viruses by proteolytic cleavage of the hemagglutinin polypeptide

1 reference

12 December 2020

Synthesis of oligomers derived from amide-linked neuraminic acid analogues

1 reference

12 December 2020

Synthesis of a carbocyclic sialic acid analogue for the inhibition of influenza virus neuraminidase

1 reference

12 December 2020

Synthesis of an influenza neuraminidase inhibitor intermediate via a highly diastereoselective coupling reaction

1 reference

12 December 2020

Therapeutic options for the management of influenza

1 reference

12 December 2020

In vitro and in vivo anti-influenza A virus activity of antisense oligonucleotides

1 reference

12 December 2020

Highlights in the development of new antiviral agents

1 reference

12 December 2020

Novel assay for the influenza virus M2 channel activity

1 reference

12 December 2020

Inhibition of influenza virus A/WSN replication by a trypsin inhibitor, 6-amidino-2-naphthyl p-guanidinobenzoate

1 reference

12 December 2020

Monomeric inhibitors of influenza neuraminidase enhance the hemagglutination inhibition activities of polyacrylamides presenting multiple C-sialoside groups

1 reference

12 December 2020

Triflimide activation of a chiral oxazaborolidine leads to a more general catalytic system for enantioselective Diels-Alder addition.

1 reference

12 December 2020

Metal ion catalysis of RNA cleavage by the influenza virus endonuclease

1 reference

12 December 2020

Synthesis and antiviral activity evaluation of some aminoadamantane derivatives

1 reference

12 December 2020

Polyacrylamides bearing pendant alpha-sialoside groups strongly inhibit agglutination of erythrocytes by influenza A virus: multivalency and steric stabilization of particulate biological systems

1 reference

12 December 2020

Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides

1 reference

12 December 2020

Inhibition of influenza virus hemagglutinin-mediated membrane fusion by a compound related to podocarpic acid

1 reference

12 December 2020

Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity

1 reference

12 December 2020

A novel mechanism for the acquisition of virulence by a human influenza A virus

1 reference

12 December 2020

Synthesis and biological evaluation of novel bisheterocycle-containing compounds as potential anti-influenza virus agents

1 reference

12 December 2020

Effect of the virostatic Norakin (triperiden) on influenza virus activities

1 reference

12 December 2020

Design and synthesis of benzoic acid derivatives as influenza neuraminidase inhibitors using structure-based drug design

1 reference

12 December 2020

BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design

1 reference

12 December 2020

THE IN VIVO ANTIVIRAL ACTIVITY OF 1-ADAMANTANAMINE (AMANTADINE). I. PROPHYLACTIC AND THERAPEUTIC ACTIVITY AGAINST INFLUENZA VIRUSES.

1 reference

12 December 2020

A short enantioselective pathway for the synthesis of the anti-influenza neuramidase inhibitor oseltamivir from 1,3-butadiene and acrylic acid

1 reference

12 December 2020

Action of epsilon-aminocaproic acid on the proteolysis system during experimental influenza in mice

1 reference

12 December 2020

ANTIVIRAL ACTIVITY OF 1-ADAMANTANAMINE (AMANTADINE).

1 reference

12 December 2020

Systematic structure-based design and stereoselective synthesis of novel multisubstituted cyclopentane derivatives with potent antiinfluenza activity

1 reference

12 December 2020

Salicylamide inhibitors of influenza virus fusion

1 reference

12 December 2020

Role of hemagglutinin cleavage for the pathogenicity of influenza virus.

1 reference

12 December 2020

Comparison of the anti-influenza virus activity of RWJ-270201 with those of oseltamivir and zanamivir

1 reference

12 December 2020

Inhibitory effect of a protease inhibitor, leupeptin, on the development of influenza pneumonia, mediated by concomitant bacteria

1 reference

12 December 2020

Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors

1 reference

12 December 2020

Sialidase inhibitors related to zanamivir: synthesis and biological evaluation of 4H-pyran 6-ether and ketone

1 reference

12 December 2020

Oseltamivir becomes plentiful--but still not cheap

1 reference

12 December 2020

Inhibitory effect of bafilomycin A1, a specific inhibitor of vacuolar-type proton pump, on the growth of influenza A and B viruses in MDCK cells

1 reference

12 December 2020

Synthesis of natural flutimide and analogous fully substituted pyrazine-2,6-diones, endonuclease inhibitors of influenza virus

1 reference

12 December 2020

Direct inactivation of viruses by human granulocyte defensins

1 reference

12 December 2020

Crystallographic detection of a second ligand binding site in influenza virus hemagglutinin

1 reference

12 December 2020

Effective inhibitors of hemagglutination by influenza virus synthesized from polymers having active ester groups. Insight into mechanism of inhibition

1 reference

12 December 2020

Prevention and treatment of experimental influenza A virus infection in volunteers with a new antiviral ICI 130,685.

1 reference

12 December 2020

Inhibition of influenza A virus replication by compounds interfering with the fusogenic function of the viral hemagglutinin

1 reference

12 December 2020

Cyclopentane neuraminidase inhibitors with potent in vitro anti-influenza virus activities

1 reference

12 December 2020

A novel antiviral agent which inhibits the endonuclease of influenza viruses

1 reference

12 December 2020

In vitro characterization of A-315675, a highly potent inhibitor of A and B strain influenza virus neuraminidases and influenza virus replication

1 reference

12 December 2020

Synthesis and evaluation of 1,4,5,6-tetrahydropyridazine derivatives as influenza neuraminidase inhibitors

1 reference

12 December 2020

In vitro and in vivo activities of anti-influenza virus compound T-705.

1 reference

12 December 2020

Influenza: old and new threats

1 reference

12 December 2020

Synthesis of substituted 1-norbornylamines with antiviral activity

1 reference

12 December 2020

Recent advances in anti-influenza agents with neuraminidase as target

1 reference

12 December 2020

Mode of action of the anti-influenza virus activity of plant flavonoid, 5,7,4'-trihydroxy-8-methoxyflavone, from the roots of Scutellaria baicalensis

1 reference

12 December 2020

Intravenous ribavirin by constant infusion for serious influenza and parainfluenzavirus infection.

1 reference

12 December 2020

Spiro[pyrrolidine-2,2'-adamantanes]: synthesis, anti-influenza virus activity and conformational properties

1 reference

12 December 2020

Synthesis and antiviral activity evaluation of some new aminoadamantane derivatives. 2.

1 reference

12 December 2020

Heterocyclic rimantadine analogues with antiviral activity

1 reference

12 December 2020

Anti-influenza virus activities of 4-substituted 2,4-dioxobutanoic acid inhibitors

1 reference

12 December 2020

A new synthesis of Neu5Ac from D-glucono-delta-lactone

1 reference

12 December 2020

Synthesis of 6-acetamido-5-amino- and -5-guanidino-3, 4-dehydro-N-(2-ethylbutyryl)- 3-piperidinecarboxylic acids related to zanamivir and oseltamivir, inhibitors of influenza virus neuraminidases

1 reference

12 December 2020

Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: modifications of essential pyrrolidinone ring substituents.

1 reference

12 December 2020

Molecular mechanism underlying the action of a novel fusion inhibitor of influenza A virus

1 reference

12 December 2020

Cell tropism of influenza virus mediated by hemagglutinin activation at the stage of virus entry

1 reference

12 December 2020

Synthesis of 2-(2-adamantyl)piperidines and structure anti-influenza virus A activity relationship study using a combination of NMR spectroscopy and molecular modeling

1 reference

12 December 2020

New, azide-free transformation of epoxides into 1,2-diamino compounds: synthesis of the anti-influenza neuraminidase inhibitor oseltamivir phosphate (Tamiflu).

1 reference

12 December 2020

Highly potent and long-acting trimeric and tetrameric inhibitors of influenza virus neuraminidase

1 reference

12 December 2020

Structure-based identification of an inducer of the low-pH conformational change in the influenza virus hemagglutinin: irreversible inhibition of infectivity

1 reference

12 December 2020

The Synthetic Development of the Anti-Influenza Neuraminidase Inhibitor Oseltamivir Phosphate (Tamiflu ® ): A Challenge for Synthesis & Process Research

1 reference

COCI

https://opencitations.net/index/coci/api/v1/citations/10.2533/000942904777677605

8 July 2023

Identifiers

DOI

10.1002/MED.20096

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15 August 2017

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