Structure-activity relationship and pharmacology of gamma-aminobutyric acid (GABA) transport inhibitors. (Q36686930)

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23 December 2019

review article

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title

Structure-activity relationship and pharmacology of gamma-aminobutyric acid (GABA) transport inhibitors (English)

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23 December 2019

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1

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23 December 2019

Arne Schousboe

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23 December 2019

author name string

Karsten Madsen

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23 December 2019

Orla Miller Larsson

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23 December 2019

Bente Frølund

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23 December 2019

Povl Krogsgaard-Larsen

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23 December 2019

publication date

1 January 2006

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23 December 2019

published in

Advances in Pharmacology

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23 December 2019

volume

54

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23 December 2019

page(s)

265-284

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alpha4beta3delta GABA(A) receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential

23 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Orally active and potent inhibitors of gamma-aminobutyric acid uptake

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (tiagabine) as an anticonvulsant drug candidate

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Synthesis of novel GABA uptake inhibitors. 4. Bioisosteric transformation and successive optimization of known GABA uptake inhibitors leading to a series of potent anticonvulsant drug candidates

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Synthesis of novel gamma-aminobutyric acid (GABA) uptake inhibitors. 5.(1) Preparation and structure-activity studies of tricyclic analogues of known GABA uptake inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Synthesis of novel GABA uptake inhibitors. Part 6: preparation and evaluation of N-Omega asymmetrically substituted nipecotic acid derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Tyrosine 140 of the gamma-aminobutyric acid transporter GAT-1 plays a critical role in neurotransmitter recognition

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Action of bicyclic isoxazole GABA analogues on GABA transporters and its relation to anticonvulsant activity

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

GABA transporter heterogeneity: pharmacology and cellular localization

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

(R)-N-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]nipecotic acid binds with high affinity to the brain gamma-aminobutyric acid uptake carrier

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Neuronal and glial localization of GAT-1, a high-affinity gamma-aminobutyric acid plasma membrane transporter, in human cerebral cortex: with a note on its distribution in monkey cortex

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives as GABA uptake inhibitors: identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT-3.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Localization of messenger RNAs encoding three GABA transporters in rat brain: an in situ hybridization study

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Selective inhibitors of glial GABA uptake: synthesis, absolute stereochemistry, and pharmacology of the enantiomers of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and analogues

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Cloning and expression of a rat brain GABA transporter

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Uptake and metabolism of γ-aminobutyric acid by neurones and glial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

The uptake of [3H]GABA by slices of rat cerebral cortex

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Synthesis of novel GABA uptake inhibitors. 3. Diaryloxime and diarylvinyl ether derivatives of nipecotic acid and guvacine as anticonvulsant agents.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Inhibition of GABA uptake in rat brain slices by nipecotic acid, various isoxazoles and related compounds

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Structure and biological activity of a series of conformationally restricted analogues of GABA

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogs of THIP. Synthesis and biological activity

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Effect of Homo-?-Proline and Other Heterocyclic GAB A Analogues on GABA Uptake in Neurons and Astroglial Cells and on GABA Receptor Binding

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Differences in uptake kinetics of cis-3-aminocyclohexane carboxylic acid into neurons and astrocytes in primary cultures

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Kinetic characterization of inhibition of gamma-aminobutyric acid uptake into cultured neurons and astrocytes by 4,4-diphenyl-3-butenyl derivatives of nipecotic acid and guvacine.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

GAT-3, a high-affinity GABA plasma membrane transporter, is localized to astrocytic processes, and it is not confined to the vicinity of GABAergic synapses in the cerebral cortex.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Cis-3-aminocyclohexanecarboxylic acid: a substrate for the neuronal GABA transport system.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Structure-activity studies on benzhydrol-containing nipecotic acid and guvacine derivatives as potent, orally-active inhibitors of GABA uptake

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Immunocytochemical localization of the GABA transporter in rat brain.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Effects of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazol (exo-THPO) and its N-substituted analogs on GABA transport in cultured neurons and astrocytes and by the four cloned mouse GABA transporters

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Inhibition of the high-affinity, net uptake of GABA into cultured astrocytes by beta-proline, nipecotic acid and other compounds.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Effects of GABA analogues of restricted conformation on GABA transport in astrocytes and brain cortex slices and on GABA receptor binding

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Transport and Metabolism of 7-Aminobutyric Acid in Neurons and Glia: Implications for Epilepsy

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Tiagabine and gabapentin for the management of chronic pain

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Compartmentation of Glutamine, Glutamate, and GABA Metabolism in Neurons and Astrocytes: Functional Implications

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

Correlation between anticonvulsant activity and inhibitory action on glial gamma-aminobutyric acid uptake of the highly selective mouse gamma-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and its N-

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

A light and electron microscopic study of betaine/GABA transporter distribution in the monkey cerebral neocortex and hippocampus

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2806%2954011-6

7 January 2021

10.1016/S1054-3589(06)54011-6

Identifiers

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23 December 2019

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