Systems-based medicine approaches to understand and treat complex diseases. The example of multiple sclerosis (Q36687908)

15 August 2017

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title

Systems-based medicine approaches to understand and treat complex diseases. The example of multiple sclerosis (English)

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15 August 2017

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Sergio E Baranzini

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15 August 2017

language of work or name

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1 December 2006

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15 August 2017

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15 August 2017

volume

39

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15 August 2017

issue

8

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15 August 2017

page(s)

651-662

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The limits of reductionism in medicine: could systems biology offer an alternative?

15 August 2017

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Natural history of multiple sclerosis: a unifying concept

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A population-based study of multiple sclerosis in twins: update.

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The British Isles survey of multiple sclerosis in twins

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How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis

21 January 2018

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The use of animal models to investigate the pathogenesis of neuroinflammatory disorders of the central nervous system

21 January 2018

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An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis

21 January 2018

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Experimental autoimmune encephalomyelitis: immunotherapy with anti-tumor necrosis factor antibodies and soluble tumor necrosis factor receptors

21 January 2018

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Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2.

21 January 2018

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CAMPATH-1 monoclonal antibody therapy in severe refractory autoimmune thrombocytopenic purpura

21 January 2018

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Preliminary evidence from magnetic resonance imaging for reduction in disease activity after lymphocyte depletion in multiple sclerosis

21 January 2018

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Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis

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Intrathecal Interferon Reduces Exacerbations of Multiple Sclerosis

21 January 2018

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Genetic analysis of multiple sclerosis

21 January 2018

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The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease

21 January 2018

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Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

21 January 2018

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Multiple sclerosis as a generalized CNS disease--comparative microarray analysis of normal appearing white matter and lesions in secondary progressive MS.

21 January 2018

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Blood transcriptional signatures of multiple sclerosis: unique gene expression of disease activity

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CNS gene expression pattern associated with spontaneous experimental autoimmune encephalomyelitis.

21 January 2018

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cDNA microarray analysis in multiple sclerosis lesions: detection of genes associated with disease activity

21 January 2018

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Microarray gene expression profiling of chronic active and inactive lesions in multiple sclerosis.

21 January 2018

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Quantitative and qualitative changes in gene expression patterns characterize the activity of plaques in multiple sclerosis

21 January 2018

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Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients

21 January 2018

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Biomedical informatics: the future for drug development

21 January 2018

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Modeling transcriptional regulatory networks

21 January 2018

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Integrative analysis of cell cycle control in budding yeast

21 January 2018

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Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination

21 January 2018

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Use of combination therapy with immunomodulators and immunosuppressants in treating multiple sclerosis

21 January 2018

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Immunomodulatory synergy by combination of atorvastatin and glatiramer acetate in treatment of CNS autoimmunity

21 January 2018

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Combination therapy for multiple sclerosis: the treatment strategy of the future?

21 January 2018

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Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis

21 January 2018

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The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses

21 January 2018

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Bax-ablation attenuates experimental autoimmune encephalomyelitis in mice

21 January 2018

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T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice.

21 January 2018

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CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis

21 January 2018

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Interactions between hemopoietically derived TNF and central nervous system-resident glial chemokines underlie initiation of autoimmune inflammation in the brain

21 January 2018

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CD1-dependent regulation of chronic central nervous system inflammation in experimental autoimmune encephalomyelitis.

21 January 2018

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Down-regulation of the macrophage lineage through interaction with OX2 (CD200)

21 January 2018

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CD40-mediated activation of T cells accelerates, but is not required for, encephalitogenic potential of myelin basic protein-recognizing T cells in a model of progressive experimental autoimmune encephalomyelitis

21 January 2018

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De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis.

21 January 2018

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Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation

21 January 2018

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Severe disease, unaltered leukocyte migration, and reduced IFN-gamma production in CXCR3-/- mice with experimental autoimmune encephalomyelitis

21 January 2018

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DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming

21 January 2018

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ERK1-/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis.

21 January 2018

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Resistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions.

21 January 2018

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Cutting edge: Requirement for growth hormone-releasing hormone in the development of experimental autoimmune encephalomyelitis

21 January 2018

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Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen-presenting cells

21 January 2018

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ICOS co-stimulatory receptor is essential for T-cell activation and function

21 January 2018

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Interferon-gamma confers resistance to experimental allergic encephalomyelitis.

21 January 2018

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IFN-gamma shapes immune invasion of the central nervous system via regulation of chemokines.

21 January 2018

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IFN-beta gene deletion leads to augmented and chronic demyelinating experimental autoimmune encephalomyelitis.

21 January 2018

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Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12

21 January 2018

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Role of IL-12 Receptor β1 in Regulation of T Cell Response by APC in Experimental Autoimmune Encephalomyelitis

21 January 2018

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Interleukin-2 gene deletion produces a robust reduction in susceptibility to experimental autoimmune encephalomyelitis in C57BL/6 mice.

21 January 2018

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Interleukin-6 functions in autoimmune encephalomyelitis: a study in gene-targeted mice

21 January 2018

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Protection from autoimmune brain inflammation in mice lacking IFN-regulatory factor-1 is associated with Th2-type cytokines

21 January 2018

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A critical role for lymphotoxin in experimental allergic encephalomyelitis

21 January 2018

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Increased severity of experimental allergic encephalomyelitis in lyn-/- mice in the absence of elevated proinflammatory cytokine response in the central nervous system.

21 January 2018

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Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis

21 January 2018

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Myelin/oligodendrocyte glycoprotein-deficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wild-type mice

21 January 2018

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CD134 plays a crucial role in the pathogenesis of EAE and is upregulated in the CNS of patients with multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08916930601061686

Deficient p75 low-affinity neurotrophin receptor expression exacerbates experimental allergic encephalomyelitis in C57/BL6 mice.

21 January 2018

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https://api.crossref.org/works/10.1080%2F08916930601061686

Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1080%2F08916930601061686

Myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis is chronic/relapsing in perforin knockout mice, but monophasic in Fas- and Fas ligand-deficient lpr and gld mice

21 January 2018

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https://api.crossref.org/works/10.1080%2F08916930601061686

Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice

21 January 2018

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A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions

21 January 2018

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Exacerbation of experimental autoimmune encephalomyelitis in P2X7R-/- mice: evidence for loss of apoptotic activity in lymphocytes

21 January 2018

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Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis

21 January 2018

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Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis

21 January 2018

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Critical points of tumor necrosis factor action in central nervous system autoimmune inflammation defined by gene targeting

21 January 2018

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https://api.crossref.org/works/10.1080%2F08916930601061686

TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination.

21 January 2018

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https://api.crossref.org/works/10.1080%2F08916930601061686

Impairment of TNF-receptor-1 signaling but not fas signaling diminishes T-cell apoptosis in myelin oligodendrocyte glycoprotein peptide-induced chronic demyelinating autoimmune encephalomyelitis in mice

21 January 2018

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Divergent roles for p55 and p75 tumor necrosis factor receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis.

21 January 2018

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Vav1-deficient mice are resistant to MOG-induced experimental autoimmune encephalomyelitis due to impaired antigen priming.

21 January 2018

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Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α

21 January 2018

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https://api.crossref.org/works/10.1080%2F08916930601061686

A meta-analysis of genomic screens in multiple sclerosis

21 January 2018

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https://api.crossref.org/works/10.1080%2F08916930601061686

Induction of experimental autoimmune encephalomyelitis in C57BL/6 mice deficient in either the chemokine macrophage inflammatory protein-1alpha or its CCR5 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08916930601061686

10.1080/08916930601061686

21 January 2018

Identifiers

DOI

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15 August 2017

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