Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes (Q36688361)

15 August 2017

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title

Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes (English)

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15 August 2017

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Christian Rask-Madsen

series ordinal

1

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PubMed ID

17179929

15 August 2017

George L King

series ordinal

2

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15 August 2017

1 January 2007

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Nature Clinical Practice Endocrinology and Metabolism

15 August 2017

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15 August 2017

3

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15 August 2017

46-56

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15 August 2017

1

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Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension

15 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Roles of thromboxane A(2) and prostacyclin in the development of atherosclerosis in apoE-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes

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https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Endothelial dysfunction in diabetes.

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https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance

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https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Inhibition of protein kinase Cbeta prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Mechanisms underlying endothelial dysfunction in diabetes mellitus

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https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Peroxynitrite and vascular endothelial dysfunction in diabetes mellitus.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

High glucose causes upregulation of cyclooxygenase-2 and alters prostanoid profile in human endothelial cells: role of protein kinase C and reactive oxygen species

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Increased activity of endogenous endothelin in patients with type II diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Hyperreactivity to nitrovasodilators in forearm vasculature is related to autonomic dysfunction in insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Prognostic role of reversible endothelial dysfunction in hypertensive postmenopausal women

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

The effect of statin therapy on endothelial function in type 2 diabetes without manifest cardiovascular disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase

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https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

A mechanosensory complex that mediates the endothelial cell response to fluid shear stress

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulin-resistant rats

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Effects of simulated hyperglycemia, insulin, and glucagon on endothelial nitric oxide synthase expression

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Insulin stimulates both endothelin and nitric oxide activity in the human forearm.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Insulin therapy improves insulin-stimulated endothelial function in patients with type 2 diabetes and ischemic heart disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179).

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Insulin causes endothelial dysfunction in humans: sites and mechanisms.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Inflammation, stress, and diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Acute systemic inflammation impairs endothelium-dependent dilatation in humans

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

TNF-alpha inhibits flow and insulin signaling leading to NO production in aortic endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Tumor necrosis factor-alpha inhibits insulin's stimulating effect on glucose uptake and endothelium-dependent vasodilation in humans

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endotheli

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

The role of the adipocyte hormone adiponectin in cardiovascular disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Differential regulation of glucose transport and transporters by glucose in vascular endothelial and smooth muscle cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation: effects of short- and long-term simvastatin treatment

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Biochemistry and molecular cell biology of diabetic complications

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Central role of PKCbeta in neointimal expansion triggered by acute arterial injury.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Exacerbated vein graft arteriosclerosis in protein kinase Cdelta-null mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Oxidative stress and cardiovascular injury: Part II: animal and human studies

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Vascular NAD(P)H oxidases: specific features, expression, and regulation

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Effects of angiotensin II infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide/cGMP signaling

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Vascular respiratory uncoupling increases blood pressure and atherosclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Cardiovascular risk factors emerge after artificial selection for low aerobic capacity

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0366

7 January 2021

Identifiers

DOI

10.1038/NCPENDMET0366

1 reference

15 August 2017

1 reference

PubMed ID

17179929