Bcl-2/Bax protein ratio predicts 5-fluorouracil sensitivity independently of p53 status (Q36691968)

15 August 2017

Bcl-2/Bax protein ratio predicts 5-fluorouracil sensitivity independently of p53 status (English)

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15 August 2017

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Mirjolet JF

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15 August 2017

Barberi-Heyob M

2

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15 August 2017

Didelot C

3

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15 August 2017

Peyrat JP

4

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15 August 2017

Abecassis J

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15 August 2017

Millon R

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15 August 2017

Merlin JL

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15 August 2017

language of work or name

English

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publication date

1 November 2000

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British Journal of Cancer

15 August 2017

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15 August 2017

83

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15 August 2017

10

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15 August 2017

1380-1386

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https://scigraph.springernature.com/pub.10.1054/bjoc.2000.1455

15 August 2017

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cites work

A multifactorial approach including tumoural epidermal growth factor receptor, p53, thymidylate synthase and dihydropyrimidine dehydrogenase to predict treatment outcome in head and neck cancer patients receiving 5-fluorouracil

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Dihydropyrimidine dehydrogenase but not thymidylate synthase expression is associated with resistance to 5-fluorouracil in colorectal cancer.

30 September 2017

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5-Fluorouracil induces apoptosis in human colon cancer cell lines with modulation of Bcl-2 family proteins

30 September 2017

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Effects of p53 mutants derived from lung carcinomas on the p53-responsive element (p53RE) of the MDM2 gene

30 September 2017

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Mechanisms underlying apoptosis induced by combination of 5-fluorouracil and interferon-gamma

30 September 2017

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A p53-independent pathway for induction of p21waf1cip1 and concomitant G1 arrest in UV-irradiated human skin fibroblasts.

30 September 2017

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Regulation of p53 stability by Mdm2

30 September 2017

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Repression of p53 transcriptional activity by the HPV E7 proteins

30 September 2017

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BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway

30 September 2017

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Translational regulation of human p53 gene expression.

30 September 2017

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Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies

30 September 2017

1 reference

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New insights into p53 function from structural studies

30 September 2017

1 reference

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Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage

30 September 2017

1 reference

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p53 and translational control

30 September 2017

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mdm2 expression is induced by wild type p53 activity

30 September 2017

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p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

30 September 2017

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Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.

30 September 2017

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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

Bcl-2 and the regulation of programmed cell death

30 September 2017

1 reference

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WAF1, a potential mediator of p53 tumor suppression

30 September 2017

1 reference

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Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.

30 September 2017

1 reference

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

Relationship of p53 to the control of apoptotic cell death

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

A functional p53-responsive intronic promoter is contained within the human mdm2 gene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

Thymidylate synthase and drug resistance

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

Induction of a retinoblastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

Negative feedback regulation of wild-type p53 biosynthesis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

Primary structure polymorphism at amino acid residue 72 of human p53.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

Fluorouracil: biochemistry and pharmacology

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

Codon 72 polymorphism of the TP53 gene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

Participation of p53 protein in the cellular response to DNA damage

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

p53 function and dysfunction

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

Wild-type p53 is a cell cycle checkpoint determinant following irradiation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: blocking p53-induced apoptosis unmasks G1 arrest.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

Wild-type p53 regulates its own transcription in a cell-type specific manner

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

The mutational status of p53 protein in gastric and esophageal adenocarcinoma cell lines predicts sensitivity to chemotherapeutic agents

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

Evidence for a second cell cycle block at G2/M by p53.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

Modulation of p53 expression in cultured colonic adenoma cell lines by the naturally occurring lumenal factors butyrate and deoxycholate.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

Sequence-dependent growth-inhibitory effects of the in vitro combination of fluorouracil, cisplatin, and dipyridamole

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fluorouracil

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

The tumor suppressor p53 regulates its own transcription

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

Mechanisms of resistance to fluoropyrimidines

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

Dihydropyrimidine dehydrogenase, multidrug resistance-associated protein, and thymidylate synthase gene expression levels can predict 5-fluorouracil resistance in human gastrointestinal cancer cells.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2408783

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis

5 September 2018

1 reference

12 December 2020

Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis

1 reference

12 December 2020

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage

1 reference

12 December 2020

Alterations in mRNA stability during rat liver regeneration

1 reference

12 December 2020

Bcl-2 and Bcl-XL can differentially block chemotherapy-induced cell death

1 reference

12 December 2020

Relationship between p21 expression and mutation of the p53 tumor suppressor gene in normal and malignant ovarian epithelial cells

1 reference

12 December 2020

Bcl-2, Bax and p53 expression in B-CLL in relation to in vitro survival and clinical progression

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12 December 2020

A p53 and apoptotic independent role for p21waf1 in tumour response to radiation therapy

1 reference

12 December 2020

Identifiers

DOI

10.1054/BJOC.2000.1455

1 reference

Dimensions Publication ID

15 August 2017

0 references

1 reference

15 August 2017

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