IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques (Q36694836)

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scientific article published on 16 August 2012

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English	IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques	scientific article published on 16 August 2012

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scholarly article

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11 February 2020

IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques (English)

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11 February 2020

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Niranjan Y Sardesai

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Kate E. Broderick

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Kate E Broderick

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author name string

Rashmi Jalah

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Vainav Patel

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Viraj Kulkarni

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Margherita Rosati

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Candido Alicea

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Brunda Ganneru

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Agneta von Gegerfelt

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Wensheng Huang

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Celia LaBranche

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George N Pavlakis

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Barbara K Felber

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David C Montefiori

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publication date

16 August 2012

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11 February 2020

Human Vaccines & Immunotherapeutics

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11 February 2020

8

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11 February 2020

1620-1629

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11 February 2020

11

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11 February 2020

CD4+CD8+ T cells represent a significant portion of the anti-HIV T cell response to acute HIV infection

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Selected approaches for increasing HIV DNA vaccine immunogenicity in vivo

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30 September 2017

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30 September 2017

IL-12 selectively programs effector pathways that are stably expressed in human CD8+ effector memory T cells in vivo

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30 September 2017

Enhanced control of pathogenic Simian immunodeficiency virus SIVmac239 replication in macaques immunized with an interleukin-12 plasmid and a DNA prime-viral vector boost vaccine regimen

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1 reference

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30 September 2017

In vivo electroporation enhances the immunogenicity of an HIV-1 DNA vaccine candidate in healthy volunteers

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30 September 2017

Electroporation delivery of DNA vaccines: prospects for success

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1 reference

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30 September 2017

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1 reference

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Phase 1 safety and immunogenicity evaluation of ADVAX, a multigenic, DNA-based clade C/B' HIV-1 candidate vaccine

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30 September 2017

DNA vaccination in rhesus macaques induces potent immune responses and decreases acute and chronic viremia after SIVmac251 challenge

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30 September 2017

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Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

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30 September 2017

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Evaluating neutralizing antibodies against HIV, SIV, and SHIV in luciferase reporter gene assays

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30 September 2017

Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid

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30 September 2017

Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques

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30 September 2017

DNA vaccines expressing different forms of simian immunodeficiency virus antigens decrease viremia upon SIVmac251 challenge

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30 September 2017

Codon-optimized genes that enable increased heterologous expression in mammalian cells and elicit efficient immune responses in mice after vaccination of naked DNA.

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30 September 2017

Immunological changes in simian immunodeficiency virus (SIV(agm))-infected African green monkeys (AGM): expanded cytotoxic T lymphocyte, natural killer and B cell subsets in the natural host of SIV(agm).

1 reference

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30 September 2017

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30 September 2017

Dose-dependent and schedule-dependent effects of interleukin-12 on antigen-specific CD8 responses

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30 September 2017

Interleukin-12 (IL-12) enhancement of the cellular immune response against human immunodeficiency virus type 1 env antigen in a DNA prime/vaccinia virus boost vaccine regimen is time and dose dependent: suppressive effects of IL-12 boost are mediate

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30 September 2017

Inactivation of the human immunodeficiency virus type 1 inhibitory elements allows Rev-independent expression of Gag and Gag/protease and particle formation

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30 September 2017

Elements distinct from human immunodeficiency virus type 1 splice sites are responsible for the Rev dependence of env mRNA.

1 reference

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30 September 2017

Distinct RNA sequences in the gag region of human immunodeficiency virus type 1 decrease RNA stability and inhibit expression in the absence of Rev protein

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1 reference

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28 June 2018

Combined effects of IL-12 and electroporation enhances the potency of DNA vaccination in macaques

1 reference

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1 reference

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28 June 2018

Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones

1 reference

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28 June 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3601136

5 September 2018

Therapeutic vaccination with simian immunodeficiency virus (SIV)-DNA + IL-12 or IL-15 induces distinct CD8 memory subsets in SIV-infected macaques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3601136

5 September 2018

Increased immune responses in rhesus macaques by DNA vaccination combined with electroporation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3601136

5 September 2018

Comparative ability of plasmid IL-12 and IL-15 to enhance cellular and humoral immune responses elicited by a SIVgag plasmid DNA vaccine and alter disease progression following SHIV(89.6P) challenge in rhesus macaques.

1 reference

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5 September 2018

A dose sparing effect by plasmid encoded IL-12 adjuvant on a SIVgag-plasmid DNA vaccine in rhesus macaques

1 reference

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1 reference

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5 September 2018

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1 reference

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5 September 2018

Co-immunization with plasmid IL-12 generates a strong T-cell memory response in mice.

1 reference

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5 September 2018

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1 reference

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5 September 2018

IL-12/GM-CSF Coadministration in an SIV DNA Prime/Protein Boost Protocol Enhances Gag-Specific T Cells But Not Virus-Specific Neutralizing Antibodies in Rhesus Macaques

1 reference

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1 reference

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5 September 2018

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1 reference

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5 September 2018

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1 reference

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5 September 2018

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1 reference

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5 September 2018

SIV DNA vaccine co-administered with IL-12 expression plasmid enhances CD8 SIV cellular immune responses in cynomolgus macaques

1 reference

https://api.crossref.org/works/10.4161%2FHV.21407

21 January 2018

Macaques co-immunized with SIVgag/pol-HIVenv and IL-12 plasmid have increased cellular responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/22894956

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An enzyme-linked immunosorbent assay for antibodies to the envelope glycoproteins of divergent strains of HIV-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/22894956

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/22894956

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen

1 reference

https://pubmed.ncbi.nlm.nih.gov/22894956

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production

1 reference

https://pubmed.ncbi.nlm.nih.gov/22894956

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of amplitude and direction of in vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/22894956

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine molecular adjuvants modulate immune responses induced by DNA vaccine constructs for HIV-1 and SIV

1 reference

https://pubmed.ncbi.nlm.nih.gov/22894956

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rational design of a plasmid DNA vaccine capable of eliciting cell-mediated immune responses to multiple HIV antigens in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22894956

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rhesus macaques with high levels of vaccine induced IFN-gamma producing cells better control viral set-point following challenge with SIV239

1 reference

https://pubmed.ncbi.nlm.nih.gov/22894956

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antigen-specific humoral and cellular immune responses can be modulated in rhesus macaques through the use of IFN-gamma, IL-12, or IL-18 gene adjuvants

1 reference

https://pubmed.ncbi.nlm.nih.gov/22894956

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Gag-Pol/Env-Rev SIV239 DNA vaccine improves CD4 counts, and reduce viral loads after pathogenic intrarectal SIV(mac)251 challenge in rhesus Macaques

1 reference

https://pubmed.ncbi.nlm.nih.gov/22894956

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4161/HV.21407

1 reference

Europe PubMed Central

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11 February 2020

1 reference

Europe PubMed Central

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11 February 2020

1 reference

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11 February 2020

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