Potent synergistic anti-human immunodeficiency virus (HIV) effects using combinations of the CCR5 inhibitor aplaviroc with other anti-HIV drugs (Q36703042)

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scientific article published on 31 March 2008

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English	Potent synergistic anti-human immunodeficiency virus (HIV) effects using combinations of the CCR5 inhibitor aplaviroc with other anti-HIV drugs	scientific article published on 31 March 2008

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5 January 2020

Potent synergistic anti-human immunodeficiency virus (HIV) effects using combinations of the CCR5 inhibitor aplaviroc with other anti-HIV drugs (English)

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5 January 2020

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5 January 2020

Hirokazu Tamamura

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Hirokazu Tamamura

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5 January 2020

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Hirotomo Nakata

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5 January 2020

Seth M Steinberg

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5 January 2020

Yasuhiro Koh

3

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5 January 2020

Yoshikazu Takaoka

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5 January 2020

Nobutaka Fujii

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5 January 2020

Hiroaki Mitsuya

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31 March 2008

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5 January 2020

Antimicrobial Agents and Chemotherapy

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5 January 2020

52

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5 January 2020

2111-2119

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5 January 2020

Hepatotoxicity observed in clinical trials of aplaviroc (GW873140)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2415794

30 September 2017

Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine

1 reference

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30 September 2017

Potent antiviral synergy between monoclonal antibody and small-molecule CCR5 inhibitors of human immunodeficiency virus type 1

1 reference

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30 September 2017

Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir

1 reference

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30 September 2017

Structural and molecular interactions of CCR5 inhibitors with CCR5.

1 reference

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30 September 2017

Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity

1 reference

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30 September 2017

TAK-220, a novel small-molecule CCR5 antagonist, has favorable anti-human immunodeficiency virus interactions with other antiretrovirals in vitro

1 reference

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30 September 2017

Potent anti-R5 human immunodeficiency virus type 1 effects of a CCR5 antagonist, AK602/ONO4128/GW873140, in a novel human peripheral blood mononuclear cell nonobese diabetic-SCID, interleukin-2 receptor gamma-chain-knocked-out AIDS mouse model.

1 reference

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30 September 2017

Spirodiketopiperazine-based CCR5 inhibitor which preserves CC-chemokine/CCR5 interactions and exerts potent activity against R5 human immunodeficiency virus type 1 in vitro

1 reference

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30 September 2017

Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists

1 reference

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30 September 2017

Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives

1 reference

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30 September 2017

Strategies in the design of antiviral drugs

1 reference

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30 September 2017

Anti-human immunodeficiency virus interactions of SCH-C (SCH 351125), a CCR5 antagonist, with other antiretroviral agents in vitro

1 reference

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30 September 2017

SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo

1 reference

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30 September 2017

Novel low molecular weight spirodiketopiperazine derivatives potently inhibit R5 HIV-1 infection through their antagonistic effects on CCR5.

1 reference

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30 September 2017

CCR5, CXCR4, and CD4 are clustered and closely apposed on microvilli of human macrophages and T cells

1 reference

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30 September 2017

Viral dynamics and anti-viral pharmacodynamics: rethinking in vitro measures of drug potency

1 reference

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30 September 2017

Combination of CCR5 and CXCR4 inhibitors in therapy of human immunodeficiency virus type 1 infection: in vitro studies of mixed virus infections.

1 reference

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30 September 2017

A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

1 reference

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30 September 2017

Highly potent RANTES analogues either prevent CCR5-using human immunodeficiency virus type 1 infection in vivo or rapidly select for CXCR4-using variants.

1 reference

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30 September 2017

CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.

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30 September 2017

CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5.

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30 September 2017

Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha

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30 September 2017

CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1

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Identification of a major co-receptor for primary isolates of HIV-1

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30 September 2017

Strategic design and three-dimensional analysis of antiviral drug combinations

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30 September 2017

Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: an in vitro comparative study

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Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100

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The role of mononuclear phagocytes in HTLV-III/LAV infection

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Differences in the interaction of HIV-1 and HIV-2 with CD4

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Factors underlying spontaneous inactivation and susceptibility to neutralization of human immunodeficiency virus

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10.1128/AAC.01299-07

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5 January 2020

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