Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1. (Q36710634)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26929333%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

title

Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1 (English)

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9 March 2020

1 reference

3

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9 March 2020

12

Cobi J Heijnen

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9 March 2020

13

Annemieke Kavelaars

1 reference

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9 March 2020

author name string

Pooja Singhmar

1

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9 March 2020

XiaoJiao Huo

2

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9 March 2020

Susana Rojo Berciano

4

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9 March 2020

Faiza Baameur

5

1 reference

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9 March 2020

Fang C Mei

6

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9 March 2020

Yingmin Zhu

7

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9 March 2020

Xiaodong Cheng

8

1 reference

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9 March 2020

David Hawke

9

1 reference

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9 March 2020

Federico Mayor

10

1 reference

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9 March 2020

Cristina Murga

11

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9 March 2020

language of work or name

English

0 references

publication date

29 February 2016

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Proceedings of the National Academy of Sciences of the United States of America

9 March 2020

number of pages

6

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based on heuristic

inferred from page(s)

published in

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9 March 2020

volume

113

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9 March 2020

issue

11

1 reference

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9 March 2020

page(s)

3036-3041

1 reference

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Acidosis Mediates the Switching of Gs-PKA and Gi-PKCε Dependence in Prolonged Hyperalgesia Induced by Inflammation

9 March 2020

cites work

1 reference

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P2Y purinergic receptor-regulated insulin secretion is mediated by a cAMP/Epac/Kv channel pathway

30 September 2017

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Biochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors: defining the ESI-09 "therapeutic window".

30 September 2017

1 reference

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The future of EPAC-targeted therapies: agonism versus antagonism

30 September 2017

1 reference

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Piezo2 is the major transducer of mechanical forces for touch sensation in mice

30 September 2017

1 reference

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Nerve growth factor mediates a switch in intracellular signaling for PGE2-induced sensitization of sensory neurons from protein kinase A to Epac

30 September 2017

1 reference

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Opening paths to novel analgesics: the role of potassium channels in chronic pain

30 September 2017

1 reference

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Cyclic AMP sensor EPAC proteins and energy homeostasis

30 September 2017

1 reference

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Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.

30 September 2017

1 reference

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A role for Piezo2 in EPAC1-dependent mechanical allodynia.

30 September 2017

1 reference

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Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions

30 September 2017

1 reference

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A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion

30 September 2017

1 reference

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Transient decrease in nociceptor GRK2 expression produces long-term enhancement in inflammatory pain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801297

cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane

30 September 2017

1 reference

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A fluorescence-based high-throughput assay for the discovery of exchange protein directly activated by cyclic AMP (EPAC) antagonists

30 September 2017

1 reference

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cAMP-dependent allostery and dynamics in Epac: an NMR view.

30 September 2017

1 reference

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Putting the pH into phosphatidic acid signaling

30 September 2017

1 reference

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Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801297

Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801297

Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels

30 September 2017

1 reference

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Differential roles of Epac in regulating cell death in neuronal and myocardial cells

30 September 2017

1 reference

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GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain

30 September 2017

1 reference

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Mechanism of Epac activation: structural and functional analyses of Epac2 hinge mutants with constitutive and reduced activities

30 September 2017

1 reference

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Direct spatial control of Epac1 by cyclic AMP.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801297

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801297

8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue.

30 September 2017

1 reference

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Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state

30 September 2017

1 reference

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Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator

30 September 2017

1 reference

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Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments

30 September 2017

1 reference

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The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels

30 September 2017

1 reference

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Structure and regulation of the cAMP-binding domains of Epac2

30 September 2017

1 reference

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Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP.

30 September 2017

1 reference

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Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation

30 September 2017

1 reference

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A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase

30 September 2017

1 reference

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Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

30 September 2017

1 reference

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Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases.

30 September 2017

1 reference

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A family of cAMP-binding proteins that directly activate Rap1

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801297

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801297

Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801297

Role of protein kinase A in the maintenance of inflammatory pain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801297

GRK2 in sensory neurons regulates epinephrine-induced signalling and duration of mechanical hyperalgesia.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801297

Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801297

Pull-down assays for guanoside 5'-triphosphate-bound Ras-like guanosine 5'-triphosphatases

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801297

Genetic elimination of behavioral sensitization in mice lacking calmodulin-stimulated adenylyl cyclases

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801297

Chronic pain and quality of life following open inguinal hernia repair.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801297

Contribution of Piezo2 to endothelium-dependent pain

5 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1516036113

A role for G protein-coupled receptor kinase 2 in mechanical allodynia

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26929333

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A critical role of the cAMP sensor Epac in switching protein kinase signalling in prostaglandin E2-induced potentiation of P2X3 receptor currents in inflamed rats

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26929333

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1516036113

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26929333%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26929333%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26929333%20AND%20SRC:MED&resulttype=core&format=json