Imbalance of Hsp70 family variants fosters tau accumulation (Q36710912)

15 August 2017

Imbalance of Hsp70 family variants fosters tau accumulation (English)

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15 August 2017

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Markus Zweckstetter

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Vladimir N. Uversky

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object named as

Vladimir N Uversky

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Eckhard Mandelkow

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Umesh K Jinwal

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Elias Akoury

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15 August 2017

Jose F Abisambra

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John C O'Leary

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Andrea D Thompson

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Laura J Blair

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Ying Jin

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Justin Bacon

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Bryce A Nordhues

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Matthew Cockman

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Juan Zhang

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Pengfei Li

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Bo Zhang

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Sergiy Borysov

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Jacek Biernat

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Jason E Gestwicki

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Chad A Dickey

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15 August 2017

language of work or name

English

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publication date

27 December 2012

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15 August 2017

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1450-1459

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describes a project that uses

15 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3606536/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance

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Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

30 September 2017

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Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice.

30 September 2017

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Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden

30 September 2017

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A caspase cleaved form of tau is preferentially degraded through the autophagy pathway

30 September 2017

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Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs

30 September 2017

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Hsc70 rapidly engages tau after microtubule destabilization

30 September 2017

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Identifying the amylome, proteins capable of forming amyloid-like fibrils

30 September 2017

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The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules.

30 September 2017

1 reference

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Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

30 September 2017

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Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy

30 September 2017

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Two motifs within the tau microtubule-binding domain mediate its association with the hsc70 molecular chaperone.

30 September 2017

1 reference

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The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

30 September 2017

1 reference

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The structural biology of protein aggregation diseases: Fundamental questions and some answers

30 September 2017

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Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.

30 September 2017

1 reference

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Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channels

30 September 2017

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CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70

30 September 2017

1 reference

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In vivo evidence of CHIP up-regulation attenuating tau aggregation

30 September 2017

1 reference

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The CCPN data model for NMR spectroscopy: development of a software pipeline

30 September 2017

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Role for Hsp70 chaperone in Saccharomyces cerevisiae prion seed replication

30 September 2017

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Celastrols as inducers of the heat shock response and cytoprotection.

30 September 2017

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CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

30 September 2017

1 reference

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Chaperones increase association of tau protein with microtubules

30 September 2017

1 reference

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Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

30 September 2017

1 reference

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Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions

30 September 2017

1 reference

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A hitchhiker's guide to the human Hsp70 family

30 September 2017

1 reference

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MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

30 September 2017

1 reference

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A receptor for the selective uptake and degradation of proteins by lysosomes

30 September 2017

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Structural analysis of substrate binding by the molecular chaperone DnaK

30 September 2017

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NMRPipe: a multidimensional spectral processing system based on UNIX pipes

30 September 2017

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Expression of heat shock protein 70 is altered by age and diet at the level of transcription

30 September 2017

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Diverse forms of stress lead to new patterns of gene expression through a common and essential metabolic pathway

30 September 2017

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Maximal stress-induced transcription from the human HSP70 promoter requires interactions with the basal promoter elements independent of rotational alignment

30 September 2017

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Effects of microtubule stabilization and destabilization on tau immunoreactivity in cultured hippocampal neurons

30 September 2017

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Chemical manipulation of hsp70 ATPase activity regulates tau stability.

30 September 2017

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Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions

28 June 2018

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Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease

28 June 2018

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Interaction of Hsp70 chaperones with substrates

28 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3606536

Distribution of the phosphorylated microtubule-associated protein tau in developing cortical neurons.

28 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3606536

Stable clathrin: uncoating protein (hsc70) complexes in intact neurons and their axonal transport

28 June 2018

1 reference

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Development of fluorescence polarization assays for the molecular chaperone Hsp70 family members: Hsp72 and DnaK.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3606536

HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites

5 September 2018

1 reference

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Analysis of microtubule polymerization in vitro and during the cell cycle in Xenopus egg extracts.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3606536

Kin I kinesins are microtubule-destabilizing enzymes

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3606536

Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure

5 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23271055

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Effects of neurohormonal stress and aging on the activation of mammalian heat shock factor 1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23271055

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1096/FJ.12-220889

1 reference

15 August 2017

1 reference

15 August 2017

1 reference