Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles (Q36716533)

15 August 2017

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title

Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles (English)

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15 August 2017

Ahsan N Rizwan

1

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15 August 2017

Gerhard Burckhardt

series ordinal

2

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15 August 2017

publication date

1 March 2007

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15 August 2017

published in

Pharmaceutical Research

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15 August 2017

volume

24

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15 August 2017

issue

3

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15 August 2017

page(s)

450-470

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Gene expression levels and immunolocalization of organic ion transporters in the human kidney.

15 August 2017

cites work

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12 December 2020

A novel putative transporter maps to the osteosclerosis (oc) mutation and is not expressed in the oc mutant mouse

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12 December 2020

Regulation by protein kinase C of organic anion transport driven by rat organic anion transporter 3 (rOAT3)

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12 December 2020

Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes.

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12 December 2020

Arginine 454 and lysine 370 are essential for the anion specificity of the organic anion transporter, rOAT3.

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12 December 2020

Protein kinase C activation downregulates human organic anion transporter 1-mediated transport through carrier internalization

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12 December 2020

Mercapturic acids (N-acetylcysteine S-conjugates) as endogenous substrates for the renal organic anion transporter-1.

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12 December 2020

The dietary polyphenol ellagic acid is a potent inhibitor of hOAT1.

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12 December 2020

Expression cloning and functional characterization of the kidney cortex high-affinity proton-coupled peptide transporter

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12 December 2020

Characterization of uremic toxin transport by organic anion transporters in the kidney

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12 December 2020

The impact of plasma protein binding on the renal transport of organic anions

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12 December 2020

Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-kappaB and free radical in proximal tubular cells

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12 December 2020

Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions

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12 December 2020

Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs

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12 December 2020

Screening of the interaction between xenobiotic transporters and PDZ proteins

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12 December 2020

Characterization of ochratoxin A transport by human organic anion transporters

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12 December 2020

Two male siblings with hereditary renal hypouricemia and exercise-induced ARF.

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12 December 2020

Functional characterization of rat organic anion transporter 5 (Slc22a19) at the apical membrane of renal proximal tubules

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12 December 2020

Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient

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12 December 2020

Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules

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12 December 2020

Identification of a novel voltage-driven organic anion transporter present at apical membrane of renal proximal tubule.

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12 December 2020

Identification of a mechanism by which the methylmercury antidotes N-acetylcysteine and dimercaptopropanesulfonate enhance urinary metal excretion: transport by the renal organic anion transporter-1.

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12 December 2020

Molecular cloning and functional characterization of a polyspecific organic anion transporter from Caenorhabditis elegans

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12 December 2020

Hydrogen peroxide downregulates human organic anion transporters in the basolateral membrane of the proximal tubule

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12 December 2020

Gender-specific and developmental influences on the expression of rat organic anion transporters

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12 December 2020

Human Organic Anion Transporter 3 (hOAT3) can Operate as an Exchanger and Mediate Secretory Urate Flux

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12 December 2020

Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier

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12 December 2020

Effect of oral probenecid coadministration on the chronic toxicity and pharmacokinetics of intravenous cidofovir in cynomolgus monkeys.

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12 December 2020

Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes.

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12 December 2020

The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP.

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12 December 2020

The flounder organic anion transporter fOat has sequence, function, and substrate specificity similarity to both mammalian Oat1 and Oat3.

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12 December 2020

Human organic anion transporters mediate the transport of tetracycline

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12 December 2020

Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists

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12 December 2020

Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells.

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12 December 2020

Mouse organic anion transporter 2 and 3 (mOAT2/3[Slc22a7/8]) mediates the renal transport of bumetanide

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12 December 2020

Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine.

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12 December 2020

Urate transport via human PAH transporter hOAT1 and its gene structure

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12 December 2020

Action of EGF and PGE2 on basolateral organic anion uptake in rabbit proximal renal tubules and hOAT1 expressed in human kidney epithelial cells

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12 December 2020

Sex differences in the mRNA, protein, and functional expression of organic anion transporter (Oat) 1, Oat3, and organic cation transporter (Oct) 2 in rabbit renal proximal tubules

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12 December 2020

Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6).

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12 December 2020

Expression of slc5a8 in kidney and its role in Na(+)-coupled transport of lactate

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12 December 2020

Nephrotoxicity of beta-lactam antibiotics: mechanisms and strategies for prevention

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12 December 2020

Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney

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12 December 2020

Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus

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12 December 2020

Interaction of 2,3-dimercapto-1-propane sulfonate with the human organic anion transporter hOAT1.

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12 December 2020

Interaction of cysteine conjugates with human and rabbit organic anion transporter 1.

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12 December 2020

Role of human organic anion transporter 4 in the transport of ochratoxin A.

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12 December 2020

Molecular and cellular physiology of renal organic cation and anion transport

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12 December 2020

Presence of organic anion transporters 3 (OAT3) and 4 (OAT4) in human adrenocortical cells

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12 December 2020

The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1.

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12 December 2020

Human renal organic anion transporters: characteristics and contributions to drug and drug metabolite excretion

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12 December 2020

Cloning of a human renal p-aminohippurate transporter, hROAT1

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12 December 2020

Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid

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12 December 2020

Characterization and identification of steroid sulfate transporters of human placenta

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12 December 2020

Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney

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12 December 2020

Characterization of methotrexate transport and its drug interactions with human organic anion transporters

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12 December 2020

Altered renal elimination of organic anions in rats with chronic renal failure

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12 December 2020

Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)

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12 December 2020

Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice.

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12 December 2020

Cationic amino acids involved in dicarboxylate binding of the flounder renal organic anion transporter

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12 December 2020

Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1.

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12 December 2020

Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney

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12 December 2020

Expression of a renal type I sodium/phosphate transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions

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12 December 2020

Transport of N-acetylcysteine s-conjugates of methylmercury in Madin-Darby canine kidney cells stably transfected with human isoform of organic anion transporter 1.

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12 December 2020

Molecular physiology of urate transport

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12 December 2020

Relative contribution of OAT and OCT transporters to organic electrolyte transport in rabbit proximal tubule

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12 December 2020

Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1.

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12 December 2020

Expression cloning and characterization of a renal organic anion transporter from winter flounder

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12 December 2020

Function and localization of urate transporter 1 in mouse kidney

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12 December 2020

Clinical pharmacology of 3'-azido-2',3'-dideoxythymidine (zidovudine) and related dideoxynucleosides

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12 December 2020

Organic anion transporter (Slc22a) family members as mediators of toxicity

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12 December 2020

Molecular identification of a renal urate anion exchanger that regulates blood urate levels

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12 December 2020

Effects of renal failure on drug transport and metabolism

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12 December 2020

Short-term regulation of basolateral organic anion uptake in proximal tubular opossum kidney cells: prostaglandin E2 acts via receptor-mediated activation of protein kinase A.

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12 December 2020

Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice.

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12 December 2020

Drug uptake systems in liver and kidney

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12 December 2020

Interaction of the metal chelator 2,3-dimercapto-1-propanesulfonate with the rabbit multispecific organic anion transporter 1 (rbOAT1).

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12 December 2020

The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules

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12 December 2020

The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus

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12 December 2020

Expression cloning and characterization of a novel multispecific organic anion transporter

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12 December 2020

Organic anion transporter family: current knowledge.

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12 December 2020

Evidence for a role of human organic anion transporters in the muscular side effects of HMG-CoA reductase inhibitors

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12 December 2020

Identification of multispecific organic anion transporter 2 expressed predominantly in the liver

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12 December 2020

Uraemic toxins induce proximal tubular injury via organic anion transporter 1-mediated uptake

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12 December 2020

Molecular physiology of renal organic anion transporters

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12 December 2020

Molecular cloning and characterization of a novel liver-specific transport protein

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12 December 2020

Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood-brain barrier

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12 December 2020

Human organic anion transporters and human organic cation transporters mediate renal antiviral transport

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12 December 2020

Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites

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12 December 2020

The molecular pharmacology of organic anion transporters: from DNA to FDA?

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12 December 2020

Kidney-specific expression of a novel mouse organic cation transporter-like protein

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12 December 2020

The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics

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12 December 2020

Handling of the homocysteine S-conjugate of methylmercury by renal epithelial cells: role of organic anion transporter 1 and amino acid transporters

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12 December 2020

The SLC22 drug transporter family

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12 December 2020

Human organic anion transporter 1 mediates cellular uptake of cysteine-S conjugates of inorganic mercury

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12 December 2020

Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter

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12 December 2020

Advances in understanding the renal transport and toxicity of mercury

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12 December 2020

Mutational analysis of idiopathic renal hypouricemia in Korea

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12 December 2020

Molecular aspects of renal anionic drug transport

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12 December 2020

Interaction of the metal chelator DMPS with OAT1 and OAT3 in intact isolated rabbit renal proximal tubules

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12 December 2020

The renal Na(+)-dependent dicarboxylate transporter, NaDC-3, translocates dimethyl- and disulfhydryl-compounds and contributes to renal heavy metal detoxification

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12 December 2020

Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney

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12 December 2020

Functional expression of pig renal organic anion transporter 3 (pOAT3).

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12 December 2020

Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats

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12 December 2020

Human renal organic anion transporter 1-dependent uptake and toxicity of mercuric-thiol conjugates in Madin-Darby canine kidney cells

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12 December 2020

Rat and mouse differences in gender-predominant expression of organic anion transporter (Oat1-3; Slc22a6-8) mRNA levels

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12 December 2020

Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs

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12 December 2020

Inhibition of the human organic anion transporter 1 by the caffeine metabolite 1-methylxanthine

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12 December 2020

Acute renal failure with severe loin pain and patchy renal ischaemia after anaerobic exercise (ALPE) (exercise-induced acute renal failure) in a father and child with URAT1 mutations beyond the W258X mutation

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12 December 2020

The role of glycine residues in the function of human organic anion transporter 4

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12 December 2020

Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney

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12 December 2020

The W258X mutation in SLC22A12 is the predominant cause of Japanese renal hypouricemia

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12 December 2020

Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins

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12 December 2020

Transport of cimetidine by flounder and human renal organic anion transporter 1.

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12 December 2020

Involvement of uric acid transporter in increased renal clearance of the xanthine oxidase inhibitor oxypurinol induced by a uricosuric agent, benzbromarone.

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12 December 2020

Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors.

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12 December 2020

Interactions of human organic anion transporters with diuretics.

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12 December 2020

Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion

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12 December 2020

Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver

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12 December 2020

Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4)

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12 December 2020

Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A).

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12 December 2020

Prostaglandin E2 inhibits its own renal transport by downregulation of organic anion transporters rOAT1 and rOAT3.

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12 December 2020

Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition

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12 December 2020

Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene.

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12 December 2020

'Benemid,' p-(di-n-propylsulfamyl)-benzoic acid; its renal affinity and its elimination

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12 December 2020

Interactions of human organic anion as well as cation transporters with indoxyl sulfate

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12 December 2020

MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

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12 December 2020

Regulation of mOAT-mediated organic anion transport by okadaic acid and protein kinase C in LLC-PK(1) cells

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12 December 2020

Role of glycosylation in the organic anion transporter OAT1

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12 December 2020

Role of aromatic transmembrane residues of the organic anion transporter, rOAT3, in substrate recognition

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12 December 2020

Renal elimination of p-aminohippurate (PAH) in response to three days of biliary obstruction in the rat. The role of OAT1 and OAT3

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12 December 2020

Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C

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12 December 2020

Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones

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12 December 2020

Uptake of chemically reactive, DNA-damaging sulfuric acid esters into renal cells by human organic anion transporters

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12 December 2020

Novel aspects of renal organic anion transporters

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12 December 2020

Human renal organic anion transporter 4 operates as an asymmetric urate transporter

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12 December 2020

Expression of human organic anion transporters in the choroid plexus and their interactions with neurotransmitter metabolites

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12 December 2020

Interaction of zalcitabine with human organic anion transporter 1.

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12 December 2020

Modulatory effects of hormones, drugs, and toxic events on renal organic anion transport

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12 December 2020

Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)].

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12 December 2020

Cloning of the pig renal organic anion transporter 1 (pOAT1).

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12 December 2020

Methotrexate-loxoprofen interaction: involvement of human organic anion transporters hOAT1 and hOAT3.

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12 December 2020

Isolation of a family of organic anion transporters from human liver and kidney

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12 December 2020

Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta

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12 December 2020

Transport of organic anions across the basolateral membrane of proximal tubule cells

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12 December 2020

Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells

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12 December 2020

Interactions of stevioside and steviol with renal organic anion transporters in S2 cells and mouse renal cortical slices

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12 December 2020

A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters

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12 December 2020

Quantitative evaluation of the drug-drug interactions between methotrexate and nonsteroidal anti-inflammatory drugs in the renal uptake process based on the contribution of organic anion transporters and reduced folate carrier

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12 December 2020

Analysis of mutations in the urate transporter 1 (URAT1) gene of Japanese patients with hypouricemia in northern Japan and review of the literature

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12 December 2020

Renal elimination of organic anions in rats with bilateral ureteral obstruction

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12 December 2020

Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1.

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12 December 2020

Short-term regulation of basolateral organic anion uptake in proximal tubular OK cells: EGF acts via MAPK, PLA(2), and COX1.

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12 December 2020

Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics.

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12 December 2020

Molecular cloning and characterization of a human urate transporter (hURAT1) gene promoter

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12 December 2020

Structure-affinity relationship in the interactions of human organic anion transporter 1 with caffeine, theophylline, theobromine and their metabolites

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12 December 2020

Effects of probenecid on the pharmacokinetics and elimination of acyclovir in humans

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12 December 2020

Handling of cysteine S-conjugates of methylmercury in MDCK cells expressing human OAT1.

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12 December 2020

Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1.

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12 December 2020

Expression studies and functional characterization of renal human organic anion transporter 1 isoforms.

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12 December 2020

Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1).

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12 December 2020

Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity

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12 December 2020

Drug-associated renal dysfunction and injury

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12 December 2020

Integrated physiology of proximal tubular organic anion transport

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12 December 2020

Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions

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12 December 2020

The transport properties of the human renal Na(+)- dicarboxylate cotransporter under voltage-clamp conditions.

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12 December 2020

Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney

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12 December 2020

Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney.

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12 December 2020

Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain

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12 December 2020

Characterization of the renal tubular transport of zonampanel, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, by human organic anion transporters

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12 December 2020

Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]).

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12 December 2020

Structure of renal organic anion and cation transporters

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12 December 2020

Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney

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12 December 2020

Interaction of human organic anion transporters with various cephalosporin antibiotics

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12 December 2020

Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins.

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12 December 2020

Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney

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12 December 2020

Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8).

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12 December 2020

Molecular evidence of organic ion transporters in the rat adrenal cortex with adrenocorticotropin-regulated zonal expression

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12 December 2020

Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives in rat.

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12 December 2020

Homocysteine and the renal epithelial transport and toxicity of inorganic mercury: role of basolateral transporter organic anion transporter 1.

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12 December 2020

Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice

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12 December 2020

The nephrotoxicity of cephalosporins: an overview

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12 December 2020

Organic anion and cation transporters occur in pairs of similar and similarly expressed genes

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12 December 2020

Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters

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12 December 2020

The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4.

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12 December 2020

Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters

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12 December 2020

10.1007/S11095-006-9181-4

Identifiers

DOI

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15 August 2017

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