CYP2C8 and antimalaria drug efficacy (Q36730638)

15 August 2017

2 references

18 July 2021

CYP2C8 and antimalaria drug efficacy (English)

1 reference

15 August 2017

1 reference

18 July 2021

Gil JP

1

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author name string

Gil Berglund E

series ordinal

2

1 reference

PubMed ID

17286541

15 August 2017

language of work or name

1 reference

1 February 2007

2 references

15 August 2017

18 July 2021

2 references

15 August 2017

18 July 2021

8

1 reference

15 August 2017

187-198

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15 August 2017

2

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Creative Commons Attribution

15 August 2017

1 reference

18 July 2021

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The economic and social burden of malaria

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Combination therapy for malaria: the way forward?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Validated assays for human cytochrome P450 activities

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Impact of pharmacogenomics on neglected diseases of the developing world

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Structural diversity of human xenobiotic-metabolizing cytochrome P450 monooxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Cytochrome P450 2C8: substrates, inhibitors, pharmacogenetics, and clinical relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Gene expression in distinct regions of the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Distribution of soluble epoxide hydrolase and of cytochrome P450 2C8, 2C9, and 2J2 in human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Non-synonymous single nucleotide alterations found in the CYP2C8 gene result in reduced in vitro paclitaxel metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Five novel single nucleotide polymorphisms in the CYP2C8 gene, one of which induces a frame-shift.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Functional characterization of five novel CYP2C8 variants, G171S, R186X, R186G, K247R, and K383N, found in a Japanese population.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Coartem (artemether-lumefantrine) in Africa: the beginning of the end?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

The epidemiology of drug-resistant malaria.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for uncomplicated malaria: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

The disposition of amodiaquine in man after oral administration

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Antimalarial 4-aminoquinolines: mode of action and pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Disposition of monodesethylamodiaquine after a single oral dose of amodiaquine and three regimens for prophylaxis against Plasmodium falciparum malaria.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Pharmacokinetics of intravenous amodiaquine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Amiodarone N-deethylation by CYP2C8 and its variants, CYP2C8*3 and CYP2C8 P404A.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

The effect of the cytochrome P450 CYP2C8 polymorphism on the disposition of (R)-ibuprofen enantiomer in healthy subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

The impact of CYP2C8 polymorphism and grapefruit juice on the pharmacokinetics of repaglinide

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

The effects of human CYP2C8 genotype and fluvoxamine on the pharmacokinetics of rosiglitazone in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Amodiaquine resistant Plasmodium falciparum malaria in vivo is associated with selection of pfcrt 76T and pfmdr1 86Y.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

An integrated model of chloroquine action

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Synergism between amodiaquine and its major metabolite, desethylamodiaquine, against Plasmodium falciparum in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

High-performance liquid chromatographic method for determination of amodiaquine, chloroquine and their monodesethyl metabolites in biological samples

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

In vitro susceptibility of Gabonese wild isolates of Plasmodium falciparum to artemether, and comparison with chloroquine, quinine, halofantrine and amodiaquine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

In-vitro activity of pyronaridine and amodiaquine against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Evaluation under field conditions of the colourimetric DELI-microtest for the assessment of Plasmodium falciparum drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

In vitro activities of ferrochloroquine against 55 Senegalese isolates of Plasmodium falciparum in comparison with those of standard antimalarial drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

The disposition of oral amodiaquine in Papua New Guinean children with falciparum malaria.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Plasmodium falciparum: in vitro interactions of artemisinin with amodiaquine, pyronaridine, and chloroquine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Pharmacodynamic interactions of amodiaquine and its major metabolite desethylamodiaquine with artemisinin, quinine and atovaquone in Plasmodium falciparum in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Systematic review of amodiaquine treatment in uncomplicated malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Detection of antidrug IgG antibodies in patients with adverse drug reactions to amodiaquine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Artemisinin-based combination therapies (ACTs): best hope for malaria treatment but inaccessible to the needy!

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

In vivo and mechanistic evidence of nuclear receptor CAR induction by artemisinin.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Examination of 209 drugs for inhibition of cytochrome P450 2C8

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

On the question of dose-dependent chloroquine elimination of a single oral dose

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Pharmacokinetics of chloroquine and some of its metabolites in healthy volunteers: a single dose study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Renal dysfunction in children with uncomplicated, Plasmodium falciparum malaria in Tamale, Ghana.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Chlorproguanil/dapsone for uncomplicated Plasmodium falciparum malaria in young children: pharmacokinetics and therapeutic range

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Mutations in dhfr in Plasmodium falciparum infections selected by chlorproguanil-dapsone treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Development of dapsone toxicity in patients with inflammatory dermatoses: activity of acetylation and hydroxylation of dapsone as risk factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

CYP2C8 polymorphism frequencies among malaria patients in Zanzibar.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Short communication: high prevalence of the cytochrome P450 2C8*2 mutation in Northern Ghana

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Genetic polymorphism of CYP2C8 in three Malaysian ethnics: CYP2C8*2 and CYP2C8*3 are found in Malaysian Indians.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

The Prevalence of CYP2C8, 2C9, 2J2, and soluble epoxide hydrolase polymorphisms in African Americans with hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

CYP2C8 polymorphism among the Portuguese

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Genetic polymorphisms of CYP2C8 in Japanese population.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.2.187

Assessment of the pharmacodynamic properties of antimalarial drugs in vivo

21 January 2018

1 reference

12 December 2020

Physicochemical properties correlated with drug resistance and the reversal of drug resistance in Plasmodium falciparum

1 reference

12 December 2020

In vitro sensitivity of Plasmodium falciparum to amodiaquine compared with other major antimalarials in Madagascar

1 reference

12 December 2020

The ears of the hippopotamus: manifestations, determinants, and estimates of the malaria burden

1 reference

12 December 2020

Induction of CYP2C genes in human hepatocytes in primary culture

1 reference

12 December 2020

Susceptibility of Colombian Plasmodium falciparum isolates to 4-aminoquinolines and the definition of amodiaquine resistance in vitro

1 reference

12 December 2020

Sensitive analysis of blood for amodiaquine and three metabolites by high-performance liquid chromatography with electrochemical detection

1 reference

12 December 2020

Association of CYP2C8, CYP3A4, CYP3A5, and ABCB1 polymorphisms with the pharmacokinetics of paclitaxel

1 reference

12 December 2020

Amodiaquine as a prodrug: importance of metabolite(s) in the antimalarial effect of amodiaquine in humans

1 reference

12 December 2020

Amodiaquine for treating malaria

1 reference

12 December 2020

Comparative evaluation of efficacy and safety of artesunate-lumefantrine vs. artemether-lumefantrine fixed-dose combination in the treatment of uncomplicated Plasmodium falciparum malaria

1 reference

12 December 2020

CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes

1 reference

12 December 2020

Amodiaquine induced agranulocytosis and liver damage.

1 reference

12 December 2020

The bioactivation of amodiaquine by human polymorphonuclear leucocytes in vitro: Chemical mechanisms and the effects of fluorine substitution

1 reference

12 December 2020

CYP2C8/9 mediate dapsone N-hydroxylation at clinical concentrations of dapsone.

1 reference

12 December 2020

Identifiers

DOI

10.2217/14622416.8.2.187

1 reference

15 August 2017

0 references

1 reference

PubMed ID

17286541