In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen (Q36736936)

16 August 2017

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen (English)

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16 August 2017

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Elizabeth A Winzeler

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Peter G. Schultz

18

object named as

Peter G Schultz

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16 August 2017

12

Nathanael S Gray

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16 August 2017

David Plouffe

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16 August 2017

Achim Brinker

2

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16 August 2017

Case McNamara

3

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Kerstin Henson

4

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16 August 2017

Nobutaka Kato

5

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Kelli Kuhen

6

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Advait Nagle

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Francisco Adrián

8

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16 August 2017

Jason T Matzen

9

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Paul Anderson

10

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Tae-Gyu Nam

11

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16 August 2017

Arnab Chatterjee

13

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Jeff Janes

14

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16 August 2017

S Frank Yan

15

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Richard Trager

16

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Jeremy S Caldwell

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Yingyao Zhou

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16 August 2017

language of work or name

English

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publication date

25 June 2008

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Proceedings of the National Academy of Sciences of the United States of America

16 August 2017

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16 August 2017

105

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16 August 2017

9059-9064

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26

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Evidence-based annotation of the malaria parasite's genome using comparative expression profiling

16 August 2017

1 reference

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Folate metabolism as a source of molecular targets for antimalarials.

29 September 2017

1 reference

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Large-scale annotation of small-molecule libraries using public databases

29 September 2017

1 reference

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Drugs for bad bugs: confronting the challenges of antibacterial discovery

29 September 2017

1 reference

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Knowledge-based chemoinformatic approaches to drug discovery

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1 reference

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High-throughput Plasmodium falciparum growth assay for malaria drug discovery

29 September 2017

1 reference

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Searching for new antimalarial therapeutics amongst known drugs

29 September 2017

1 reference

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A clinical drug library screen identifies astemizole as an antimalarial agent

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Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems

29 September 2017

1 reference

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Novel statistical approach for primary high-throughput screening hit selection

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1 reference

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Malarial (Plasmodium falciparum) dihydrofolate reductase-thymidylate synthase: structural basis for antifolate resistance and development of effective inhibitors

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1 reference

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Mechanisms of resistance of malaria parasites to antifolates

29 September 2017

1 reference

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Novel, rapid, and inexpensive cell-based quantification of antimalarial drug efficacy.

29 September 2017

1 reference

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Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening.

29 September 2017

1 reference

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Insights into antifolate resistance from malarial DHFR-TS structures

29 September 2017

1 reference

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Inhibitors of the Plasmodium falciparum parasite aspartic protease plasmepsin II as potential antimalarial agents

29 September 2017

1 reference

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Fulfilling the promise: drug discovery in the post-genomic era.

29 September 2017

1 reference

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A colorimetric in vitro drug sensitivity assay for Plasmodium falciparum based on a highly sensitive double-site lactate dehydrogenase antigen-capture enzyme-linked immunosorbent assay.

29 September 2017

1 reference

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

29 September 2017

1 reference

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Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.

29 September 2017

1 reference

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An information-intensive approach to the molecular pharmacology of cancer.

29 September 2017

1 reference

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Methionine recycling pathways and antimalarial drug design

29 September 2017

1 reference

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Antimalarial properties of bredinin. Prediction based on identification of differences in human host-parasite purine metabolism

29 September 2017

1 reference

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Use of radioactive ethanolamine incorporation into phospholipids to assess in vitro antimalarial activity by the semiautomated microdilution technique

29 September 2017

1 reference

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Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

29 September 2017

1 reference

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Assessment and continued validation of the malaria SYBR green I-based fluorescence assay for use in malaria drug screening

29 September 2017

1 reference

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In vitro and in vivo evaluation of betulinic acid as an antimalarial

28 June 2018

1 reference

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Genomic profiling of drug sensitivities via induced haploinsufficiency.

28 June 2018

1 reference

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Folate antagonists. 22. Antimalarial and antibacterial effects of 2,4-diamino-6-quinazolinesulfonamides

28 June 2018

1 reference

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Evaluation of in vitro drug sensitivity of human Plasmodium falciparum by incorporation of radioactive isoleucine

28 June 2018

1 reference

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Prolonged inhibition of protein and glycoprotein synthesis in tumor cells treated with muconomycin A.

28 June 2018

1 reference

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A novel DNA-based microfluorimetric method to evaluate antimalarial drug activity.

28 June 2018

1 reference

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Cytotoxicity and the inhibition of ribosomal RNA processing in human colon carcinoma cells

5 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18579783

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibition of bovine and rat liver dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(4-substituted-phenyl)-s-triazines

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18579783

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Calcium channel blockers inhibit cellular uptake of thymidine, uridine and leucine: the incorporation of these molecules into DNA, RNA and protein in the presence of calcium channel blockers is not a valid measure of lymphocyte activation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18579783

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0802982105

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16 August 2017

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16 August 2017

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