Therapeutic potential of TGF-beta inhibition in chronic renal failure (Q36739752)

16 August 2017

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title

Therapeutic potential of TGF-beta inhibition in chronic renal failure (English)

1 reference

16 August 2017

Elena Gagliardini

1

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PubMed ID

17309322

16 August 2017

Ariela Benigni

series ordinal

2

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PubMed ID

17309322

16 August 2017

language of work or name

English

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publication date

1 March 2007

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Expert Opinion on Biological Therapy

16 August 2017

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16 August 2017

7

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16 August 2017

3

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16 August 2017

293-304

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Strategies for making more organs available for transplantation

16 August 2017

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https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Role of transforming growth factor beta in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximal-tubule epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Signaling mechanism of TGF-beta1 in prevention of renal inflammation: role of Smad7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Tubulo-interstitial lesions mediate renal damage in adriamycin glomerulopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Is glomerulosclerosis a consequence of altered glomerular permeability to macromolecules?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Albumin up-regulates the type II transforming growth factor-beta receptor in cultured proximal tubular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Albumin induces cellular fibrosis by upregulating transforming growth factor-beta ligand and its receptors in renal distal tubule cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Transforming growth factor-beta1 is up-regulated by podocytes in response to excess intraglomerular passage of proteins: a central pathway in progressive glomerulosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

TGF-beta concentration specifies differential signaling profiles of growth arrest/differentiation and apoptosis in podocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Smad7 mediates transforming growth factor-beta-induced apoptosis in mesangial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Transforming growth factor-beta1 potentiates renal tubular epithelial cell death by a mechanism independent of Smad signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Hypoxia-enhanced expression of the proprotein convertase furin is mediated by hypoxia-inducible factor-1: impact on the bioactivation of proproteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

TGF-beta and glomerulonephritis: anti-inflammatory versus prosclerotic actions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Divergent effects of low versus high dose anti-TGF-beta antibody in puromycin aminonucleoside nephropathy in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Proximal tubular cells promote fibrogenesis by TGF-beta1-mediated induction of peritubular myofibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

How to fully protect the kidney in a severe model of progressive nephropathy: a multidrug approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Renin-angiotensin system blockade prevents the increase in plasma transforming growth factor beta 1, and reduces proteinuria and kidney hypertrophy in the streptozotocin-diabetic rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Expression of transforming growth factor-beta1 and type IV collagen in the renal tubulointerstitium in experimental diabetes: effects of ACE inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Add-on anti-TGF-beta antibody to ACE inhibitor arrests progressive diabetic nephropathy in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Angiotensin converting enzyme inhibitor suppresses glomerular transforming growth factor beta receptor expression in experimental diabetes in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

A role of oxidative stress-generated eicosanoid in the progression of arteriosclerosis in type 2 diabetes mellitus model rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

TGF-beta receptor expression and binding in rat mesangial cells: modulation by glucose and cyclic mechanical strain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Elevated glucose stimulates TGF-beta gene expression and bioactivity in proximal tubule

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Advanced glycation end-products induce connective tissue growth factor-mediated renal fibrosis predominantly through transforming growth factor beta-independent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Activation of the TGF-beta/Smad signaling pathway in focal segmental glomerulosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Urinary concentration of transforming growth factor-beta-inducible gene-h3(beta ig-h3) in patients with Type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Gene therapy by transforming growth factor-beta receptor-IgG Fc chimera suppressed extracellular matrix accumulation in experimental glomerulonephritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Antibody to transforming growth factor-beta ameliorates tubular apoptosis in unilateral ureteral obstruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Treatment with anti-TGF-beta antibody ameliorates chronic progressive nephritis by inhibiting Smad/TGF-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Effect of anti-transforming growth factor-beta antibodies in cyclosporine-induced renal dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Therapeutic role of TGF-beta-neutralizing antibody in mouse cyclosporin A nephropathy: morphologic improvement associated with functional preservation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Reversibility of established diabetic glomerulopathy by anti-TGF-beta antibodies in db/db mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Transforming growth factor-beta, 20-HETE interaction, and glomerular injury in Dahl salt-sensitive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

TGF-beta1 siRNA suppresses the tubulointerstitial fibrosis in the kidney of ureteral obstruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

N-acetyl-seryl-aspartyl-lysyl-proline ameliorates the progression of renal dysfunction and fibrosis in WKY rats with established anti-glomerular basement membrane nephritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Modulation of the transforming growth factor beta1 by vitamin E in early nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Pirfenidone treatment decreases transforming growth factor-beta1 and matrix proteins and ameliorates fibrosis in chronic cyclosporine nephrotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Pirfenidone improves renal function and fibrosis in the post-obstructed kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Peroxisome proliferator-activated receptor-gamma agonist troglitazone protects against nondiabetic glomerulosclerosis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Hyaluronan attenuates transforming growth factor-beta1-mediated signaling in renal proximal tubular epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Role of ERK1/2 and p38 mitogen-activated protein kinases in the regulation of thrombospondin-1 by TGF-beta1 in rat proximal tubular cells and mouse fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Thrombospondin-1 is a major activator of TGF-beta in fibrotic renal disease in the rat in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Neutralization of transforming growth factor-beta attenuates hypertension and prevents renal injury in uremic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Emilin1 links TGF-beta maturation to blood pressure homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Effects of hypertension, diabetes mellitus, and hypercholesterolemia on endothelin type B receptor-mediated nitric oxide release from rat kidney.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Clinical renoprotection trials involving angiotensin II-receptor antagonists and angiotensin-converting-enzyme inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Preventing microalbuminuria in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Antiproteinuric efficacy of losartan in comparison with amlodipine in non-diabetic proteinuric renal diseases: a double-blind, randomized clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Reversal of lesions of diabetic nephropathy after pancreas transplantation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

ACE inhibition reduces glomerulosclerosis and regenerates glomerular tissue in a model of progressive renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Effect of angiotensin II antagonism on the regression of kidney disease in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Application of antibody array technology in the analysis of urinary cytokine profiles in patients with chronic kidney disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Urinary transforming growth factor-beta1 in feline chronic renal failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Urinary Transforming Growth Factor-beta 1 as a marker of response to immunosuppressive treatment, in patients with crescentic nephritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Beneficial effect of TGFbeta antagonism in treating diabetic nephropathy depends on when treatment is started

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.3.293

21 January 2018

Identifiers

DOI

10.1517/14712598.7.3.293

1 reference

16 August 2017

1 reference

PubMed ID

17309322