Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9. (Q36740874)

16 August 2017

Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9. (English)

1 reference

16 August 2017

0 references

Ekambar R Kandimalla

1

1 reference

16 August 2017

Lakshmi Bhagat

2

1 reference

16 August 2017

Daqing Wang

3

1 reference

16 August 2017

Dong Yu

4

1 reference

16 August 2017

Tim Sullivan

5

1 reference

16 August 2017

Nicola La Monica

6

1 reference

16 August 2017

Sudhir Agrawal

7

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16 August 2017

language of work or name

English

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publication date

8 February 2013

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16 August 2017

Nucleic Acids Research

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16 August 2017

41

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16 August 2017

6

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16 August 2017

3947-3961

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Creative Commons Attribution-NonCommercial 3.0 Unported

16 August 2017

start time

12 May 2017

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Hydroxychloroquine in lupus: emerging evidence supporting multiple beneficial effects

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Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus

29 September 2017

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Emerging therapies for systemic lupus erythematosus--focus on targeting interferon-alpha

29 September 2017

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TLR7 and TLR9 in SLE: when sensing self goes wrong

29 September 2017

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The discovery and development of belimumab: the anti-BLyS-lupus connection

29 September 2017

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The role of antimalarial agents in the treatment of SLE and lupus nephritis

29 September 2017

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Interferon alpha as a primary pathogenic factor in human lupus

29 September 2017

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Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines

29 September 2017

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Optimal oligonucleotide sequences for TLR9 inhibitory activity in human cells: lack of correlation with TLR9 binding

29 September 2017

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Hydroxychloroquine: from malaria to autoimmunity

29 September 2017

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TLR8 deficiency leads to autoimmunity in mice

29 September 2017

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TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

29 September 2017

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Classification, mechanisms of action, and therapeutic applications of inhibitory oligonucleotides for Toll-like receptors (TLR) 7 and 9.

29 September 2017

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

29 September 2017

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TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus

29 September 2017

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DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Fas(lpr/lpr) mice in vivo

29 September 2017

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Oligodeoxyribonucleotide-based antagonists for Toll-like receptors 7 and 9.

29 September 2017

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Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

29 September 2017

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Stabilized immune modulatory RNA compounds as agonists of Toll-like receptors 7 and 8.

29 September 2017

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Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.

29 September 2017

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Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis

29 September 2017

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Interferon pathway activation in systemic lupus erythematosus

29 September 2017

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Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

29 September 2017

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G-rich DNA suppresses systemic lupus.

29 September 2017

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Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616729

Suppressive oligodeoxynucleotides inhibit Th1 differentiation by blocking IFN-gamma- and IL-12-mediated signaling.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616729

Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation

29 September 2017

1 reference

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Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616729

'Immunomers'--novel 3'-3'-linked CpG oligodeoxyribonucleotides as potent immunomodulatory agents

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616729

Conjugation of ligands at the 5'-end of CpG DNA affects immunostimulatory activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616729

Antisense and/or immunostimulatory oligonucleotide therapeutics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616729

CpG stimulation of primary mouse B cells is blocked by inhibitory oligodeoxyribonucleotides at a site proximal to NF-kappaB activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616729

Inhibition of murine macrophage IL-12 production by natural and synthetic DNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616729

Site of chemical modifications in CpG containing phosphorothioate oligodeoxynucleotide modulates its immunostimulatory activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616729

Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616729

Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: in vitro and in vivo studies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616729

Anti-malarial drugs: possible mechanisms of action in autoimmune disease and prospects for drug development.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616729

Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616729

Toll-like receptor 7 selective synthetic oligoribonucleotide agonists: synthesis and structure-activity relationship studies

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616729

Agonists of Toll-like receptor 9 containing synthetic dinucleotide motifs

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616729

Suppressive oligonucleotides protect against collagen-induced arthritis in mice.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616729

Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB × NZW mice

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3616729

Immunostimulatory activity of CpG oligonucleotides containing non-ionic methylphosphonate linkages

4 December 2018

1 reference

12 December 2020

In vivo pharmacokinetics of phosphorothioate oligonucleotides containing contiguous guanosines

1 reference

12 December 2020

A Suppressive Oligodeoxynucleotide Enhances the Efficacy of Myelin Cocktail/IL-4-Tolerizing DNA Vaccination and Treats Autoimmune Disease

1 reference

12 December 2020

DNA and RNA autoantigens as autoadjuvants

1 reference

12 December 2020

Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms

1 reference

12 December 2020

Regression of systemic lupus erythematosus after development of an acquired toll-like receptor signaling defect and antibody deficiency

1 reference

12 December 2020

Peptide conjugation at the 5'-end of oligodeoxynucleotides abrogates toll-like receptor 9-mediated immune stimulatory activity

1 reference

12 December 2020

Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice

1 reference

12 December 2020

Immunostimulatory activity of CpG containing phosphorothioate oligodeoxynucleotide is modulated by modification of a single deoxynucleoside

1 reference

12 December 2020

Accessible 5'-end of CpG-containing phosphorothioate oligodeoxynucleotides is essential for immunostimulatory activity

1 reference

12 December 2020

Modifications incorporated in CpG motifs of oligodeoxynucleotides lead to antagonist activity of toll-like receptors 7 and 9

1 reference

12 December 2020

Identifiers

DOI

10.1093/NAR/GKT078

1 reference

16 August 2017

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16 August 2017

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