Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication. (Q36752433)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18579778%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

title

Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication (English)

1 reference

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9 January 2020

2

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9 January 2020

Juan Méndez

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18579778%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

author name string

Arkaitz Ibarra

series ordinal

1

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9 January 2020

language of work or name

English

0 references

publication date

25 June 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18579778%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

9 January 2020

published in

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9 January 2020

volume

105

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9 January 2020

issue

26

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9 January 2020

page(s)

8956-8961

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Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.

9 January 2020

cites work

1 reference

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Differential requirements for MCM proteins in DNA replication in Drosophila S2 cells

29 September 2017

1 reference

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Cell cycle regulation of DNA replication.

29 September 2017

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Replication foci dynamics: replication patterns are modulated by S-phase checkpoint kinases in fission yeast.

29 September 2017

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

29 September 2017

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Cdc45-MCM-GINS, a new power player for DNA replication.

29 September 2017

1 reference

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Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase

29 September 2017

1 reference

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Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449346

The DNA replication factor MCM5 is essential for Stat1-mediated transcriptional activation

29 September 2017

1 reference

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Pumps, paradoxes and ploughshares: mechanism of the MCM2-7 DNA helicase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449346

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

29 September 2017

1 reference

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Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449346

ATR and ATM regulate the timing of DNA replication origin firing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449346

Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases

29 September 2017

1 reference

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Deregulation of cyclin E in human cells interferes with prereplication complex assembly

29 September 2017

1 reference

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The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation

29 September 2017

1 reference

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Perpetuating the double helix: molecular machines at eukaryotic DNA replication origins

29 September 2017

1 reference

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Replication protein A-mediated recruitment and activation of Rad17 complexes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449346

Paradoxes of eukaryotic DNA replication: MCM proteins and the random completion problem.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449346

A rotary pumping model for helicase function of MCM proteins at a distance from replication forks.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449346

Deregulated G1-cyclin expression induces genomic instability by preventing efficient pre-RC formation

29 September 2017

1 reference

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To cycle or not to cycle: a critical decision in cancer.

29 September 2017

1 reference

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Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

29 September 2017

1 reference

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Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449346

Dynamic molecular combing: stretching the whole human genome for high-resolution studies.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449346

Physical interactions among Mcm proteins and effects of Mcm dosage on DNA replication in Saccharomyces cerevisiae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449346

Chk1 regulates the density of active replication origins during the vertebrate S phase.

29 September 2017

1 reference

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Deregulated cyclin E induces chromosome instability

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2449346

Reduced Mcm2 expression results in severe stem/progenitor cell deficiency and cancer.

28 June 2018

1 reference

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A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice.

5 September 2018

1 reference

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Control of replication origin density and firing time in Xenopus egg extracts: role of a caffeine-sensitive, ATR-dependent checkpoint.

5 September 2018

1 reference

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The yeast CDK inhibitor Sic1 prevents genomic instability by promoting replication origin licensing in late G(1)

5 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18579778

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibiting the expression of DNA replication-initiation proteins induces apoptosis in human cancer cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18579778

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0803978105

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18579778%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

0 references

1 reference

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9 January 2020

1 reference