Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease (Q36753752)

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29 December 2019

title

Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease (English)

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29 December 2019

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coronary artery disease

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9

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29 December 2019

author name string

Carlos Fernández-Hernando

1

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29 December 2019

Eric Ackah

2

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29 December 2019

Jun Yu

3

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29 December 2019

Yajaira Suárez

4

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29 December 2019

Takahisa Murata

5

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29 December 2019

Yasuko Iwakiri

6

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29 December 2019

Jay Prendergast

7

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29 December 2019

Robert Q Miao

8

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29 December 2019

William C Sessa

10

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29 December 2019

publication date

1 December 2007

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29 December 2019

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29 December 2019

volume

6

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29 December 2019

issue

6

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29 December 2019

page(s)

446-457

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Cytokines in atherosclerosis: pathogenic and regulatory pathways

29 December 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3621848

Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3621848

Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3621848

Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency

29 September 2017

1 reference

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A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development

29 September 2017

1 reference

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Role for Akt3/protein kinase Bgamma in attainment of normal brain size

29 September 2017

1 reference

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Reduced macrophage apoptosis is associated with accelerated atherosclerosis in low-density lipoprotein receptor-null mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3621848

Novel features of nitric oxide, endothelial nitric oxide synthase, and atherosclerosis

29 September 2017

1 reference

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Apoptotic cell death in atherosclerosis

29 September 2017

1 reference

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Inflammation in atherosclerosis

29 September 2017

1 reference

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Role of Akt/protein kinase B in metabolism.

29 September 2017

1 reference

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Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies.

29 September 2017

1 reference

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The macrophage foam cell as a target for therapeutic intervention

29 September 2017

1 reference

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Consequences of cellular cholesterol accumulation: basic concepts and physiological implications

29 September 2017

1 reference

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The phosphoinositide 3-kinase pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3621848

Laser capture microdissection analysis of gene expression in macrophages from atherosclerotic lesions of apolipoprotein E-deficient mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3621848

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3621848

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3621848

Atherosclerosis. the road ahead

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3621848

Myocardial infarction mediated by endothelin receptor signaling in hypercholesterolemic mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3621848

Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL

29 September 2017

1 reference

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Mechanisms of atherosclerosis--a review.

29 September 2017

1 reference

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Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3621848

Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3621848

Phenotypic and functional changes in regenerated porcine coronary endothelial cells : increased uptake of modified LDL and reduced production of NO.

28 June 2018

1 reference

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Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions.

28 June 2018

1 reference

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Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure

5 September 2018

1 reference

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Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3621848

Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis

5 September 2018

1 reference

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Macrophage-targeted overexpression of urokinase causes accelerated atherosclerosis, coronary artery occlusions, and premature death

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3621848

Decreased endothelial nitric-oxide synthase (eNOS) activity resulting from abnormal interaction between eNOS and its regulatory proteins in hypoxia-induced pulmonary hypertension

5 September 2018

1 reference

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Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3621848

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3621848

Relation Between Endothelial Cell Apoptosis and Blood Flow Direction in Human Atherosclerotic Plaques

5 September 2018

1 reference

12 December 2020

Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice

1 reference

12 December 2020

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree

1 reference

12 December 2020

Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression

1 reference

12 December 2020

Evidence that the death of macrophage foam cells contributes to the lipid core of atheroma

1 reference

12 December 2020

Apoptosis of endothelial cells. Contribution to the pathophysiology of atherosclerosis?

1 reference

12 December 2020

10.1016/J.CMET.2007.10.007

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18054314%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

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29 December 2019

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