Autophagy and other vacuolar protein degradation mechanisms (Q36777566)

16 August 2017

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title

Autophagy and other vacuolar protein degradation mechanisms (English)

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16 August 2017

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13 November 2022

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13 November 2022

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13 November 2022

author name string

P. O. Seglen

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1740188

13 November 2022

P. Bohley

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1740188

13 November 2022

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1740188

13 November 2022

publication date

1 February 1992

1 reference

16 August 2017

15 February 1992

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1740188

full work available at URL

13 November 2022

http://link.springer.com/content/pdf/10.1007/BF01923509.pdf

file format

Portable Document Format

1 reference

http://link.springer.com/article/10.1007/BF01923509/fulltext.html

13 November 2022

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http://link.springer.com/content/pdf/10.1007/BF01923509

13 November 2022

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13 November 2022

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16 August 2017

48

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16 August 2017

2

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16 August 2017

158-172

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Effect of microtubular or translational inhibitors on general cell protein degradation. Evidence for a dual catabolic pathway

16 August 2017

1 reference

https://api.crossref.org/works/10.1007%2FBF01923509

Proteolytic processing in endosomal vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01923509

Differential effects of leupeptin, monensin and colchicine on ligand degradation mediated by the two asialoglycoprotein receptor pathways in isolated rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01923509

Use of digitonin extraction to distinguish between autophagic-lysosomal sequestration and mitochondrial uptake of [14C]sucrose in hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01923509

Both endocytic and endogenous protein degradation in fibroblasts is stimulated by serum/amino acid deprivation and inhibited by 3-methyladenine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01923509

Selective control of the degradation of normal and aberrant proteins in Reuber H35 hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01923509

Post-translational arginylation of ornithine decarboxylase from rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01923509

The identification of the major excreted protein (MEP) from a transformed mouse fibroblast cell line as a catalytically active precursor form of cathepsin L

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01923509

Effects of weakly basic amines on proteolytic processing and terminal glycosylation of secretory proteins in cultured rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01923509

Extensive destruction of newly synthesized casein in mammary explants in organ culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01923509

Intracellular protein degradation in serum-deprived human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01923509

Amino acid and hormonal control of macromolecular turnover in perfused rat liver. Evidence for selective autophagy

21 January 2018

1 reference

12 December 2020

6-substituted purines: a novel class of inhibitors of endogenous protein degradation in isolated rat hepatocytes

1 reference

12 December 2020

Intracellular transport, sorting, and turnover of acetylcholinesterase. Evidence for an endoglycosidase H-sensitive form in Golgi apparatus, sarcoplasmic reticulum, and clathrin-coated vesicles and its rapid degradation by a non-lysosomal mechanism.

1 reference

12 December 2020

Metalloendoprotease inhibitors which block the differentiation of L6 myoblasts inhibit insulin degradation by the endogenous insulin-degrading enzyme

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12 December 2020

Quantitative correlation between proteolysis and macro- and microautophagy in mouse hepatocytes during starvation and refeeding

1 reference

12 December 2020

Secretion of intact proteins and peptide fragments by lysosomal pathways of protein degradation

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12 December 2020

Stimulation of lysosomal enzyme secretion by growth factors

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12 December 2020

Rates of RNA degradation in isolated rat hepatocytes. Effects of amino acids and inhibitors of lysosomal function

1 reference

12 December 2020

Ammonium chloride causes reversible inhibition of low density lipoprotein receptor recycling and accelerates receptor degradation.

1 reference

12 December 2020

Mechanism for selective secretion of a lysosomal protease by transformed mouse fibroblasts.

1 reference

12 December 2020

Effects of adrenergic agonists and antagonists on autophagic activity in isolated rat liver cells

1 reference

12 December 2020

Intracellular degradation of the transport-impaired human PiZ alpha 1-antitrypsin variant. Biochemical mapping of the degradative event among compartments of the secretory pathway

1 reference

12 December 2020

Ammonia inhibits protein secretion in isolated rat hepatocytes

1 reference

12 December 2020

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

1 reference

12 December 2020

3-Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism

1 reference

12 December 2020

Intracellular degradation of asialoglycoproteins in hepatocytes starts in a subgroup of lysosomes

1 reference

12 December 2020

Regulation of intracellular casein degradation by secreted milk proteins.

1 reference

12 December 2020

Differences in the rates of protein degradation in untransformed and transformed cell lines

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12 December 2020

In vitro uptake of particles by lysosomes

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12 December 2020

Induction of autophagy by amino-acid deprivation in perfused rat liver

1 reference

12 December 2020

59 Inhibitors of lysosomal function

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12 December 2020

Intermediate cells of the pancreas. 3. Selective autophagy and destruction of beta-granules in intermediate cells of the rat pancreas induced by alloxan and streptozotocin

1 reference

12 December 2020

Pinocytosis and intracellular degradation of exogenous protein: modulation by amino acids

1 reference

12 December 2020

Rapid turnover of low-density lipoprotein receptor by a non-lysosomal pathway in mouse macrophage J774 cells and inhibitory effect of brefeldin A.

1 reference

12 December 2020

Swainsonine inhibits glycoprotein degradation by isolated rat liver lysosomes

1 reference

12 December 2020

Use of electrical methods in the study of hepatocytic autophagy

1 reference

12 December 2020

Studies on the mechanisms of autophagy: formation of the autophagic vacuole

1 reference

12 December 2020

Paradoxical stimulation by amino acids of the degradation of [35S]methionine-labelled, short-lived protein in isolated rat hepatocytes

1 reference

12 December 2020

Characterization of an endopeptidase involved in pre-protein processing

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12 December 2020

Inhibition of mouse macrophage degradation of acetyl-low density lipoprotein by interferon-gamma

1 reference

12 December 2020

Differences in targeting and secretion of cathepsins B and L by BALB/3T3 fibroblasts and Moloney murine sarcoma virus-transformed BALB/3T3 fibroblasts.

1 reference

12 December 2020

Protein degradation in cultured cells. The effect of fresh medium, fluoride, and iodoacetate on the digestion of cellular protein of rat fibroblasts.

1 reference

12 December 2020

Intracellular protein degradation in growing, in density-inhibited, and in serum-restricted fibroblast cultures

1 reference

12 December 2020

Lysosomal acid phosphatase is transported via endosomes to lysosomes

1 reference

12 December 2020

Mechanisms of membrane protein turnover

1 reference

12 December 2020

Chloroquine diverts ACTH from a regulated to a constitutive secretory pathway in AtT-20 cells

1 reference

12 December 2020

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1 reference

12 December 2020

Regulation of endocytic pH by the Na+,K+-ATPase in living cells

1 reference

12 December 2020

Macrophage endosomes contain proteases which degrade endocytosed protein ligands

1 reference

12 December 2020

Autophagic sequestration of [14C]sucrose, introduced into rat hepatocytes by reversible electro-permeabilization

1 reference

12 December 2020

Conversion of dense lysosomes into light lysosomes during hepatocytic autophagy

1 reference

12 December 2020

Selective degradation of insulin within rat liver endosomes

1 reference

12 December 2020

Amino acid control of protein degradation in normal and leukemic human lymphocytes

1 reference

12 December 2020

3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

1 reference

12 December 2020

Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases

1 reference

12 December 2020

Quantitative relationship between autophagy and proteolysis during graded amino acid deprivation in perfused rat liver.

1 reference

12 December 2020

Experimental characterization of the autophagic-lysosomal pathway in isolated rat hepatocytes

1 reference

12 December 2020

Disparate effects of monensin and colchicine on intracellular processing of secretory proteins in cultured rat hepatocytes

1 reference

12 December 2020

Autophagic sequestration of [14C]sucrose introduced into isolated rat hepatocytes by electrical and non-electrical methods

1 reference

12 December 2020

Prelysosomal convergence of autophagic and endocytic pathways

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12 December 2020

In exocrine pancreas, the basolateral endocytic pathway converges with the autophagic pathway immediately after the early endosome

1 reference

12 December 2020

Kinetics of hydrolysis of endocytosed substrates by mammalian cultured cells: early introduction of lysosomal enzymes into the endocytic pathway

1 reference

12 December 2020

Intracellular transport of class II MHC molecules directed by invariant chain.

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12 December 2020

Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment

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12 December 2020

Cell-free protein sorting to the regulated and constitutive secretory pathways

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12 December 2020

Degradation of ornithine decarboxylase in mammalian cells is ATP dependent but ubiquitin independent

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12 December 2020

Purification and characterization of a novel calcium-dependent serine proteinase secreted from malignant hamster embryo fibroblast Nil2C2

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12 December 2020

RNA degradation in perfused rat liver as determined from the release of [14C]cytidine

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12 December 2020

Protein degradation in the endoplasmic reticulum

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12 December 2020

Calcium ion-dependent vesicle fusion in the conversion of proalbumin to albumin

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12 December 2020

Differential effects of proteinase inhibitors and amines on the lysosomal and non-lysosomal pathways of protein degradation in isolated rat hepatocytes

1 reference

12 December 2020

Covalent linkage of ribonuclease S-peptide to microinjected proteins causes their intracellular degradation to be enhanced during serum withdrawal

1 reference

12 December 2020

Transferrin receptors and cation-independent mannose-6-phosphate receptors deliver their ligands to two distinct subpopulations of multivesicular endosomes

1 reference

12 December 2020

In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells

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12 December 2020

Cathepsin D is membrane-associated in macrophage endosomes

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12 December 2020

Energy dependence of different steps in the autophagic-lysosomal pathway

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12 December 2020

Reduced autophagic activity, improved protein balance and enhanced in vitro survival of hepatocytes isolated from carcinogen-treated rats

1 reference

12 December 2020

Resolution of multiple endosomal compartments associated with the internalization of epidermal growth factor and transferrin

1 reference

12 December 2020

Functions of lysosomes

1 reference

12 December 2020

Methods in laboratory investigation. Application of test substances to the surface of rat liver in situ: opposite effects of insulin and isoproterenol on cellular autophagy

1 reference

12 December 2020

Mannose 6-phosphate receptor dependent secretion of lysosomal enzymes

1 reference

12 December 2020

Phosphorylation of native 97-kDa 3-hydroxy-3-methylglutaryl-coenzyme A reductase from rat liver. Impact on activity and degradation of the enzyme

1 reference

12 December 2020

Inhibitors and pathways of hepatocytic protein degradation.

1 reference

12 December 2020

Ammonia inhibition of protein degradation in isolated rat hepatocytes. Quantitative ultrastructural alterations in the lysosomal system

1 reference

12 December 2020

Regulation of catabolism of microinjected ribonuclease A requires the amino-terminal 20 amino acids

1 reference

12 December 2020

Solubilization and characterization of yeast signal peptidase.

1 reference

12 December 2020

The relationship between beta-adrenoceptor regulation and beta-adrenergic responsiveness in hepatocytes. Studies on acquisition, desensitization and resensitization of isoproterenol-sensitive adenylate cyclase in primary culture

1 reference

12 December 2020

Inhibition of autophagic vacuole formation and protein degradation by amino acids in isolated hepatocytes

1 reference

12 December 2020

The mannose 6-phosphate receptor and the biogenesis of lysosomes

1 reference

12 December 2020

Hepatocytic autophagy

1 reference

12 December 2020

Inhibition of protein breakdown in cultured cells is a consistent response to growth factors

1 reference

12 December 2020

Regulation of hepatic HMG-CoA reductase in vivo by reversible phosphorylation

1 reference

12 December 2020

Inhibition of lysosomal protein degradation inhibits the basal degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase

1 reference

12 December 2020

Metalloendoprotease inhibitors block protein synthesis, intracellular transport, and endocytosis in hepatoma cells

1 reference

12 December 2020

Amino acid control of autophagic sequestration and protein degradation in isolated rat hepatocytes

1 reference

12 December 2020

Degradation from the endoplasmic reticulum: disposing of newly synthesized proteins

1 reference

12 December 2020

Inhibition by insulin of valine turnover in liver. Evidence for a general control of proteolysis

1 reference

12 December 2020

Intracellular degradation of unassembled asialoglycoprotein receptor subunits: a pre-Golgi, nonlysosomal endoproteolytic cleavage

1 reference

12 December 2020

Temperature dependence of protein degradation, autophagic sequestration and mitochondrial sugar uptake in rat hepatocytes

1 reference

12 December 2020

Effects of acidotropic compounds on the secretory pathway: inhibition of secretion and processing of the third and fourth components of complement

1 reference

12 December 2020

B lymphocyte differentiation and the control of IgM mu chain expression

1 reference

12 December 2020

A possible role for Na+,K+-ATPase in regulating ATP-dependent endosome acidification

1 reference

12 December 2020

Localization of transferrin receptors and insulin-like growth factor II receptors in vesicles from 3T3-L1 adipocytes that contain intracellular glucose transporters

1 reference

12 December 2020

Activation of neutrophil calpain following its translocation to the plasma membrane induced by phorbol ester or fMet-Leu-Phe

1 reference

12 December 2020

Inhibition of hepatocytic protein degradation by methylaminopurines and inhibitors of protein synthesis.

1 reference

12 December 2020

Characterization of pro-opiocortin-converting activity in purified secretory granules from rat pituitary neurointermediate lobe

1 reference

12 December 2020

Sequestration of cytoplasmic enzymes in an autophagic vacuole-lysosomal system induced by injection of leupeptin

1 reference

12 December 2020

Weakly basic amines inhibit the proteolytic conversion of proalbumin to serum albumin in cultured rat hepatocytes

1 reference

12 December 2020

Pathways of intracellular sequestration and protein degradation in isolated rat hepatocytes

1 reference

12 December 2020

[Morphological and functional aspects of cellular autophagy]

1 reference

12 December 2020

The role of protein accumulation in the cell cycle control of human NHIK 3025 cells

1 reference

12 December 2020

The dissociation and degradation of internalized insulin occur in the endosomes of rat hepatoma cells

1 reference

12 December 2020

Effect of serum step-down on protein metabolism and proliferation kinetics of NHIK 3025 cells

1 reference

12 December 2020

A unique membrane-bound, calcium-dependent endopeptidase with specificity toward paired basic residues in rat liver Golgi fractions

1 reference

12 December 2020

Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes

1 reference

12 December 2020

Amino acid inhibition of the autophagic/lysosomal pathway of protein degradation in isolated rat hepatocytes

1 reference

12 December 2020

Cleavage of parathyroid hormone in macrophage endosomes illustrates a novel pathway for intracellular processing of proteins

1 reference

12 December 2020

Energy dependence of autophagic protein degradation in isolated rat hepatocytes

1 reference

12 December 2020

Degradation of structurally characterized proteins injected into HeLa cells. Basic measurements

1 reference

12 December 2020

Glucagon-induced autophagy and proteolysis in rat liver: mediation by selective deprivation of intracellular amino acids

1 reference

12 December 2020

Lysosomes and autophagy (author's transl)

1 reference

12 December 2020

Protein transport across the ER membrane

1 reference

12 December 2020

Heparin decreases the degradation rate of lipoprotein lipase in adipocytes

1 reference

12 December 2020

A morphometric study of the removal of phenobarbital-induced membranes from hepatocytes after cessation of threatment

1 reference

12 December 2020

Dissection of Semliki Forest virus glycoprotein delivery from the trans-Golgi network to the cell surface in permeabilized BHK cells

1 reference

12 December 2020

The effect of protein degradation on cellular growth characteristics

1 reference

12 December 2020

Mannose 6-phosphate receptors and lysosomal enzyme targeting

1 reference

12 December 2020

Lysosomal acid phosphatase is transported to lysosomes via the cell surface

1 reference

12 December 2020

Modulation of the transport of a lysosomal enzyme by PDGF.

1 reference

12 December 2020

Inhibition of catabolism of radiolabeled antibodies by tumor cells using lysosomotropic amines and carboxylic ionophores.

1 reference

12 December 2020

Sequestration and hydrolysis of electroinjected [14C]lactose as a means of investigating autophagosome-lysosome fusion in isolated rat hepatocytes.

1 reference

12 December 2020

A novel pathway for secretory proteins?

1 reference

12 December 2020

Protein synthesis and protein degradation through the cell cycle of human NHIK 3025 cells in vitro

1 reference

12 December 2020

Regulation of intracellular protein degradation in IMR-90 human diploid fibroblasts

1 reference

12 December 2020

Control of protein degradation and growth phase in normal and neoplastic cells

1 reference

12 December 2020

Autophagy of metabolically inert substances injected into fibroblasts in culture

1 reference

12 December 2020

The condensing vacuole of exocrine cells is more acidic than the mature secretory vesicle

1 reference

12 December 2020

Ammonium chloride alters secretory protein sorting within the maturing exocrine storage compartment

1 reference

12 December 2020

Proteolytic processing in a non-lysosomal compartment is required for transcytosis of protein-polylysine conjugates in cultured Madin-Darby canine kidney cells

1 reference

12 December 2020

Degradation of structurally characterized proteins injected into HeLa cells. Effects of intracellular location and the involvement of lysosomes

1 reference

12 December 2020

A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins

1 reference

12 December 2020

Secretion-coupled protein degradation: studies on mammary casein

1 reference

12 December 2020

Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment

1 reference

12 December 2020

Radiolabelled sugars as probes of hepatocytic autophagy

1 reference

12 December 2020

Mitochondrial protein import

1 reference

12 December 2020

Estradiol increases the secretion by MCF7 cells of several lysosomal pro-enzymes

1 reference

12 December 2020

Vesicles and cisternae in the trans Golgi apparatus of human fibroblasts are acidic compartments

1 reference

12 December 2020

The retention signal for soluble proteins of the endoplasmic reticulum

1 reference

12 December 2020

Selective degradation of T cell antigen receptor chains retained in a pre-Golgi compartment

1 reference

12 December 2020

Reconstitution of endosomal proteolysis in a cell-free system. Transfer of immune complexes internalized via Fc receptors to an endosomal proteolytic compartment.

1 reference

12 December 2020

Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER

1 reference

12 December 2020

Inhibition of autophagic-lysosomal delivery and autophagic lactolysis by asparagine

1 reference

12 December 2020

Immunology. The invariant dating service

1 reference

12 December 2020

Degradation of insulin in isolated liver endosomes is functionally linked to ATP-dependent endosomal acidification

1 reference

12 December 2020

Ammonium chloride inhibits basal degradation of newly synthesized collagen in human fetal lung fibroblasts

1 reference

12 December 2020

The origin and fate of microbodies in the fat body of an insect

1 reference

12 December 2020

Regulation of microautophagy and basal protein turnover in rat liver. Effects of short-term starvation

1 reference

12 December 2020

Kinetics of intracellular degradation of newly synthesized collagen

1 reference

12 December 2020

Internalization of cytoplasmic protein by hepatic lysosomes in basal and deprivation-induced proteolytic states.

1 reference

12 December 2020

Effects of insulin and anchorage on hepatocytic protein metabolism and amino acid transport

1 reference

12 December 2020

Effect of amino acid metabolites on lysosomal protein degradation. A regulatory role for kynurenine?

1 reference

12 December 2020

Trypanosome ornithine decarboxylase is stable because it lacks sequences found in the carboxyl terminus of the mouse enzyme which target the latter for intracellular degradation.

1 reference

12 December 2020

Degradation of horseradish peroxidase after microinjection into mammalian cells

1 reference

12 December 2020

Peptide signals for protein degradation within lysosomes

1 reference

12 December 2020

Uptake and degradation of proteins by isolated rat liver lysosomes. Suggestion of a microautophagic pathway of proteolysis

1 reference

12 December 2020

Use of [3H]raffinose as a specific probe of autophagic sequestration

1 reference

12 December 2020

Peptide sequences that target cytosolic proteins for lysosomal proteolysis

1 reference

12 December 2020

Lysosomal degradation of ribonuclease A and ribonuclease S-protein microinjected into the cytosol of human fibroblasts.

1 reference

12 December 2020

Transport of acid phosphatase to lysosomes does not involve passage through the cell surface

1 reference

12 December 2020

Inhibition of the Lysosomal Pathway of Protein Degradation in Isolated Rat Hepatocytes by Ammonia, Methylamine, Chloroquine and Leupeptin

1 reference

12 December 2020

Effects of puromycin and hydroxynorvaline on net production and intracellular degradation of collagen in human fetal lung fibroblasts.

1 reference

12 December 2020

Protein degradation in isolated rat hepatocytes is inhibited by ammonia

1 reference

12 December 2020

Studies on the mechanisms of autophagy: maturation of the autophagic vacuole

1 reference

12 December 2020

Protein synthesis and degradation in growth regulation in rat embryo fibroblasts: role of fast-turnover and slow-turnover protein

1 reference

12 December 2020

Role of cyclic nucleotides in the control of hepatic autophagy

1 reference

12 December 2020

Ultrastructural studies on prostatic involution in the rat. Mechanism of autophagy in epithelial cells, with special reference to the rough-surfaced endoplasmic reticulum

1 reference

12 December 2020

Lysosome function in the regulation of the secretory process in cells of the anterior pituitary gland

1 reference

12 December 2020

Rapid turnover of adenovirus E1A is determined through a co-translational mechanism that requires an aminoterminal domain.

1 reference

12 December 2020

Increased degradation in rat liver induced by vinblastine. II. Morphologic characterization

1 reference

12 December 2020

Use of a hydrolysable probe, [14C]lactose, to distinguish between pre-lysosomal and lysosomal steps in the autophagic pathway

1 reference

12 December 2020

Participation of lysosomes in basal proteolysis in perfused rat liver. Discrepancy between leupeptin-induced lysosomal enlargement and inhibition of proteolysis

1 reference

12 December 2020

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48

3688

P. Briozzo

1988

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383

P.B. Gordon

1991

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45

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P. B. Gordon

1986

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389

I. Holen

1991

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50

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O. W. Press

1990

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50

373

P. O. Seglen

1991

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P. O. Seglen

1986

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13 November 2022

Identifiers

DOI

10.1007/BF01923509

1 reference

16 August 2017

1 reference