Molecular mechanisms in chronic obstructive pulmonary disease: potential targets for therapy (Q36779299)

16 August 2017

1 reference

title

Molecular mechanisms in chronic obstructive pulmonary disease: potential targets for therapy (English)

1 reference

chronic obstructive pulmonary disease

16 August 2017

1 reference

Willem I de Boer

1

1 reference

16 August 2017

Vijay K T Alagappan

series ordinal

2

1 reference

16 August 2017

Hari S Sharma

series ordinal

3

1 reference

16 August 2017

1 January 2007

1 reference

Cell Biochemistry and Biophysics

16 August 2017

1 reference

16 August 2017

47

1 reference

16 August 2017

1

1 reference

16 August 2017

131-148

1 reference

https://scigraph.springernature.com/pub.10.1385/cbb:47:1:131

16 August 2017

0 references

cites work

Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Burden and clinical features of chronic obstructive pulmonary disease (COPD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Asthma as a risk factor for COPD in a longitudinal study

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Association of tumor necrosis factor-alpha gene promoter polymorphism with low attenuation areas on high-resolution CT in patients with COPD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Antioxidant gene polymorphisms and susceptibility to a rapid decline in lung function in smokers

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

ROS in the local and systemic pathogenesis of COPD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Pathophysiology of airflow limitation in chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Enhanced expression of fibroblast growth factors and receptor FGFR-1 during vascular remodeling in chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Chronic obstructive pulmonary disease: molecular and cellularmechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Inflammatory features of nasal mucosa in smokers with and without COPD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Cytokines and therapy in COPD: a promising combination?

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

The relations between structural changes in small airways and pulmonary-function tests

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

The impact of smoking cessation on respiratory symptoms, lung function, airway hyperresponsiveness and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Viral infections in obstructive airway diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Involvement of the epidermal growth factor receptor in epithelial repair in asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Structural basis for fibroblast growth factor receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Fibroblast growth factors in epithelial repair and cytoprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Chronic obstructive pulmonary disease is associated with enhanced bronchial expression of FGF-1, FGF-2, and FGFR-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Epithelial expression and release of FGF-2 from heparan sulphate binding sites in bronchial tissue in asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Enhanced bronchial expression of vascular endothelial growth factor and receptors (Flk-1 and Flt-1) in patients with chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Overexpression of placenta growth factor contributes to the pathogenesis of pulmonary emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Lung-targeted VEGF inactivation leads to an emphysema phenotype in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Vascular endothelial growth factor receptor Flt-1 negatively regulates developmental blood vessel formation by modulating endothelial cell division.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Inhibition of VEGF receptors causes lung cell apoptosis and emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Decreased expression of TGF-beta type II receptor in bronchial glands of smokers with COPD

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Synthetic responses in airway smooth muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Role of extracellular matrix and its regulators in human airway smooth muscle biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Matrix metalloproteinase expression and activity in human airway smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Angiotensin II induces hypertrophy of human airway smooth muscle cells: expression of transcription factors and transforming growth factor-beta1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Expression of connective tissue growth factor in asthmatic airway smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Potential new drugs for therapy of chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Perspectives for cytokine antagonist therapy in COPD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Impaired healing of nitrogen mustard wounds in CXCR2 null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Bioactive interleukin-8 is expressed in wounds and enhances wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Induction of MCP-1 expression in airway epithelial cells: role of CCR2 receptor in airway epithelial injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Expression and functional implications of CCR2 expression on murine alveolar epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Costimulation of fibroblast collagen and transforming growth factor beta1 gene expression by monocyte chemoattractant protein-1 via specific receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

TGF-beta1 stimulates monocyte chemoattractant protein-1 expression in mesangial cells through a phosphodiesterase isoenzyme 4-dependent process

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Management of chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Therapy for chronic obstructive pulmonary disease in the 21st century.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Prospects for new drugs for chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Expression of ErbB receptors and mucins in the airways of long term current smokers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Use of the humanized anti-epidermal growth factor receptor monoclonal antibody h-R3 in combination with radiotherapy in the treatment of locally advanced head and neck cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Mechanism of action of anti-HER2 monoclonal antibodies: scientific update on trastuzumab and 2C4

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

United States Food and Drug Administration Drug Approval summary: Gefitinib (ZD1839; Iressa) tablets

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Molecular mechanisms of ZD1839-induced G1-cell cycle arrest and apoptosis in human lung adenocarcinoma A549 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

The biology of VEGF and its receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Anti-vascular endothelial growth factor monoclonals in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Development of vascular endothelial growth factor receptor (VEGFR) kinase inhibitors as anti-angiogenic agents in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Resistance to anti-VEGF agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Upregulated expression of fibroblast growth factor (FGF) receptors by transforming growth factor-beta1 (TGF-beta1) mediates enhanced mitogenic responses to FGFs in cultured human lung fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Adenoviral expression of a transforming growth factor-beta1 antisense mRNA is effective in preventing liver fibrosis in bile-duct ligated rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Tumor necrosis factor-alpha +489G/A gene polymorphism is associated with chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Tumor necrosis factor-alpha is central to acute cigarette smoke-induced inflammation and connective tissue breakdown

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Tumor necrosis factor-alpha drives 70% of cigarette smoke-induced emphysema in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

First study of infliximab treatment in patients with chronic obstructive pulmonary disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Effect of tumor necrosis factor antagonism on allergen-mediated asthmatic airway inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Evidence of a role of tumor necrosis factor alpha in refractory asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Biological agents for rheumatoid arthritis: targeting both physical function and structural damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-alpha-converting enzyme in human airway epithelial (NCI-H292) cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Therapeutic inhibition of matrix metalloproteinases for the treatment of chronic obstructive pulmonary disease (COPD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment o

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Anti-TNF-alpha therapies: the next generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Blockade of CCR2 ameliorates progressive fibrosis in kidney.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

The role of nuclear factor kappa B in the pathogenesis of pulmonary diseases: implications for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Signaling molecules as therapeutic targets in allergic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

The IKK NF-kappa B system: a treasure trove for drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

A murine model of chronic inflammation-induced intestinal fibrosis down-regulated by antisense NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Air pollution particles produce airway wall remodeling in rat tracheal explants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Application of small interfering RNA (siRNA) for modulation of airway epithelial gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Mechanisms of drug inhibition of signalling molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells, via PKC, EGF/TGF-alpha, Ras/Raf, MEK, ERK and Sp1-dependent mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Smads as intracellular mediators of airway inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

SMAD-signaling in chronic obstructive pulmonary disease: transcriptional down-regulation of inhibitory SMAD 6 and 7 by cigarette smoke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Systemic effects of chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

Infections and Airway Inflammation in Chronic Obstructive Pulmonary Disease Severe Exacerbations

21 January 2018

1 reference

https://api.crossref.org/works/10.1385%2FCBB%3A47%3A1%3A131

21 January 2018

Identifiers

DOI

10.1385/CBB:47:1:131

1 reference

Dimensions Publication ID

16 August 2017

0 references

1 reference