A clickable inhibitor reveals context-dependent autoactivation of p90 RSK (Q36790127)

16 August 2017

A clickable inhibitor reveals context-dependent autoactivation of p90 RSK (English)

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16 August 2017

Michael S Cohen

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16 August 2017

Haralambos Hadjivassiliou

series ordinal

2

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16 August 2017

Jack Taunton

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3

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16 August 2017

28 January 2007

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16 August 2017

Nature Chemical Biology

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16 August 2017

3

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16 August 2017

3

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16 August 2017

156-160

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describes a project that uses

16 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3634365/fullTextXML

inferred from PubMed Central ID database lookup

cites work

BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

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The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

29 September 2017

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Inhibiting p90 ribosomal S6 kinase prevents (Na+)-H+ exchanger-mediated cardiac ischemia-reperfusion injury

29 September 2017

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Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium

29 September 2017

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Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes

29 September 2017

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Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling

29 September 2017

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Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis

29 September 2017

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Structural bioinformatics-based design of selective, irreversible kinase inhibitors

29 September 2017

1 reference

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Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation

29 September 2017

1 reference

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Polytriazoles as copper(I)-stabilizing ligands in catalysis

29 September 2017

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Upstream and downstream of mTOR

29 September 2017

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Profiling enzyme activities in vivo using click chemistry methods

29 September 2017

1 reference

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S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

29 September 2017

1 reference

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Mycobacterium marinum Escapes from Phagosomes and Is Propelled by Actin-based Motility

29 September 2017

1 reference

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Characterization of the p90 ribosomal S6 kinase 2 carboxyl-terminal domain as a protein kinase

29 September 2017

1 reference

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Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

29 September 2017

1 reference

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A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

29 September 2017

1 reference

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90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

29 September 2017

1 reference

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Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK.

29 September 2017

1 reference

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Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo

29 September 2017

1 reference

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Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK

29 September 2017

1 reference

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Evidence for two catalytically active kinase domains in pp90rsk

29 September 2017

1 reference

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A MAP kinase docking site is required for phosphorylation and activation of p90(rsk)/MAPKAP kinase-1.

29 September 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO859

A strategy for functional proteomic analysis of glycosidase activity from cell lysates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO859

Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO859

Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO859

RSK and MSK in MAP kinase signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO859

Identification of serine 380 as the major site of autophosphorylation of Xenopus pp90rsk

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17259979

12 December 2020

inferred from PubMed ID database lookup

Comparison of the specificities of p70 S6 kinase and MAPKAP kinase-1 identifies a relatively specific substrate for p70 S6 kinase: the N-terminal kinase domain of MAPKAP kinase-1 is essential for peptide phosphorylation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17259979

12 December 2020

inferred from PubMed ID database lookup

Divergent Functional Roles for p90 Kinase Domains

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17259979

12 December 2020

inferred from PubMed ID database lookup

Attenuation of proteasome-induced proteolysis in skeletal muscle by {beta}-hydroxy-{beta}-methylbutyrate in cancer-induced muscle loss

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO859

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCHEMBIO859

1 reference

Dimensions Publication ID

16 August 2017

0 references

1 reference

16 August 2017

PubMed publication ID

17259979

1 reference