Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling (Q36790410)

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scientific article published on 25 June 2008

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English	Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling	scientific article published on 25 June 2008

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scholarly article

1 reference

Europe PubMed Central

16 August 2017

Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling (English)

1 reference

Europe PubMed Central

16 August 2017

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Johanne Martel-Pelletier

5

object named as

Johanne Martel-Pelletier

1 reference

Europe PubMed Central

16 August 2017

Jean-Pierre Pelletier

3

object named as

Jean-Pierre Pelletier

1 reference

Europe PubMed Central

16 August 2017

Christelle Boileau

1

object named as

Christelle Boileau

1 reference

Europe PubMed Central

16 August 2017

Steeve Kwan Tat

2

object named as

Steeve Kwan Tat

1 reference

Europe PubMed Central

16 August 2017

Saranette Cheng

4

object named as

Saranette Cheng

1 reference

Europe PubMed Central

16 August 2017

publication date

25 June 2008

1 reference

Europe PubMed Central

16 August 2017

Arthritis Research and Therapy

1 reference

Europe PubMed Central

16 August 2017

10

1 reference

Europe PubMed Central

16 August 2017

3

1 reference

Europe PubMed Central

16 August 2017

R71

1 reference

Europe PubMed Central

16 August 2017

https://scigraph.springernature.com/pub.10.1186/ar2444

0 references

The differential expression of osteoprotegerin (OPG) and receptor activator of nuclear factor kappaB ligand (RANKL) in human osteoarthritic subchondral bone osteoblasts is an indicator of the metabolic state of these disease cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

29 September 2017

The role of Ca+2 on rhein-induced apoptosis in human cervical cancer Ca Ski cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

29 September 2017

Induction of apoptosis of osteoclasts by targeting transcription factors with decoy molecules.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

29 September 2017

Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

29 September 2017

Relevance of an in vitro osteoclastogenesis system to study receptor activator of NF-kB ligand and osteoprotegerin biological activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

29 September 2017

Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

29 September 2017

Transcriptional regulation of collagenase‐3 by interleukin‐1 alpha in osteoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

29 September 2017

Can altered production of interleukin-1beta, interleukin-6, transforming growth factor-beta and prostaglandin E(2) by isolated human subchondral osteoblasts identify two subgroups of osteoarthritic patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

29 September 2017

IL-1 regulates cytoskeletal organization in osteoclasts via TNF receptor-associated factor 6/c-Src complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

29 September 2017

Minireview: the OPG/RANKL/RANK system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

29 September 2017

Rhein, an active metabolite of diacerein, suppresses the interleukin-1alpha-induced proteoglycan degradation in cultured rabbit articular chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

29 September 2017

Cellular mechanisms and the role of cytokines in bone erosions in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

29 September 2017

Regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) by bone resorptive factors in osteoblastic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

29 September 2017

Localization of rat cathepsin K in osteoclasts and resorption pits: inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

29 September 2017

Cysteine proteinase cathepsin K mRNA is expressed in synovium of patients with rheumatoid arthritis and is detected at sites of synovial bone destruction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

29 September 2017

Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

29 September 2017

Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

29 September 2017

Prostaglandin E2 strongly inhibits human osteoclast formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

27 June 2018

Differential expression patterns of matrix metalloproteinases and their inhibitors during development of osteoarthritis in a transgenic mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

27 June 2018

Caspases (interleukin-1beta-converting enzyme family proteases) are involved in the regulation of the survival of osteoclasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

27 June 2018

Osteoarthritis in cynomolgus macaques. III: Effects of age, gender, and subchondral bone thickness on the severity of disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

27 June 2018

Protein synthetic activity and adenylate energy charge in Rhein-treated cultured human glioma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

27 June 2018

Rhein, a diacerhein-derived metabolite, modulates the expression of matrix degrading enzymes and the cell proliferation of articular chondrocytes by inhibiting ERK and JNK-AP-1 dependent pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

5 September 2018

RANKL-stimulated osteoclast-like cell formation in vitro is partially dependent on endogenous interleukin-1 production.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

5 September 2018

Effects of rhein on activity of caspase-3 in kidney and cell apoptosis on the progression of renal injury in glomerulosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

5 September 2018

The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

5 September 2018

Rhein inhibits interleukin-1 beta-induced activation of MEK/ERK pathway and DNA binding of NF-kappa B and AP-1 in chondrocytes cultured in hypoxia: a potential mechanism for its disease-modifying effect in osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

5 September 2018

Rhein induces apoptosis in cancer cells and shows synergy with mitomycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

5 September 2018

A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

5 September 2018

Pharmacological studies of diacerein in animal models of inflammation, arthritis and bone resorption

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

5 September 2018

Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

5 September 2018

The effects of orally administered diacerein on cartilage and subchondral bone in an ovine model of osteoarthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

5 September 2018

Diacerein reduces the excess synthesis of bone remodeling factors by human osteoblast cells from osteoarthritic subchondral bone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

5 September 2018

Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

5 September 2018

Osteoblast-like cells from human subchondral osteoarthritic bone demonstrate an altered phenotype in vitro: possible role in subchondral bone sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2483463

5 September 2018

Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18578867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-interleukin-1 effects of diacerein and rhein in human osteoarthritic synovial tissue and cartilage cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/18578867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiological scoring of osteoarthritis progression in STR/ORT mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18578867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for increased bone resorption in patients with progressive knee osteoarthritis: longitudinal results from the Chingford study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18578867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tibial cancellous bone changes in patients with knee osteoarthritis. A short-term longitudinal study using Fractal Signature Analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18578867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production

1 reference

https://pubmed.ncbi.nlm.nih.gov/18578867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of rhein on the biosynthesis of prostaglandin-like substances in-vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18578867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteoarthritis in cynomolgus macaques: a primate model of naturally occurring disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18578867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A longitudinal study of subchondral plate and trabecular bone in cruciate-deficient dogs with osteoarthritis followed up for 54 months

1 reference

https://pubmed.ncbi.nlm.nih.gov/18578867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rhein inhibits glucose uptake in Ehrlich ascites tumor cells by alteration of membrane-associated functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18578867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degenerative joint disease in the guinea pig. Use of magnetic resonance imaging to monitor progression of bone pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/18578867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of matrix metalloproteinases (MMP-2, -3, -9, and -13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorption

1 reference

https://pubmed.ncbi.nlm.nih.gov/18578867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro effects of diacerhein and rhein on interleukin 1 and tumor necrosis factor-alpha systems in human osteoarthritic synovium and chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18578867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Study of immunoelectron microscopic localization of cathepsin K in osteoclasts and other bone cells in the mouse femur

1 reference

https://pubmed.ncbi.nlm.nih.gov/18578867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diacerhein and rhein reduce the interleukin 1beta stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18578867

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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Europe PubMed Central

16 August 2017

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Europe PubMed Central

16 August 2017

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Europe PubMed Central

16 August 2017

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