S-Nitrosylation and uncompetitive/fast off-rate (UFO) drug therapy in neurodegenerative disorders of protein misfolding (Q36790561)

16 August 2017

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title

S-Nitrosylation and uncompetitive/fast off-rate (UFO) drug therapy in neurodegenerative disorders of protein misfolding (English)

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16 August 2017

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Nakamura T

1

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PubMed ID

17431424

16 August 2017

Lipton SA

series ordinal

2

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16 August 2017

13 April 2007

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16 August 2017

10

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Cell Death & Differentiation

inferred from page(s)

published in

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16 August 2017

14

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16 August 2017

7

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16 August 2017

1305-1314

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4402138

16 August 2017

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Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond

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7 January 2021

Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate

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7 January 2021

Excitatory amino acids as a final common pathway for neurologic disorders.

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7 January 2021

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Attenuation of NMDA receptor activity and neurotoxicity by nitroxyl anion, NO-.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Cysteine regulation of protein function--as exemplified by NMDA-receptor modulation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Suppression of apoptosis by nitric oxide via inhibition of interleukin-1beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Fas-induced caspase denitrosylation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

S-Nitrosylation of mitochondrial caspases

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Suppression of neuronal apoptosis by S-nitrosylation of caspases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Comment on "S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function".

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Magnesium gates glutamate-activated channels in mouse central neurones

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

NMDA-dependent superoxide production and neurotoxicity.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Experimental models of Parkinson's disease

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Expanding insights of mitochondrial dysfunction in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: implications for oxygen sensing and hypoxic signaling in eukaryotes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Nitric oxide: a physiologic messenger molecule

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Locally distributed synaptic potentiation in the hippocampus.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Protein S-nitrosylation: purview and parameters

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

(S)NO signals: translocation, regulation, and a consensus motif

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

S-nitrosylation regulates apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Protein S-nitrosylation: a physiological signal for neuronal nitric oxide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Characterization of the S-denitrosation activity of protein disulfide isomerase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Redox signaling: nitrosylation and related target interactions of nitric oxide

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Nitrosylation. the prototypic redox-based signaling mechanism.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Oxidative modifications in nitrosative stress

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Nitroxyl disulfides, novel intermediates in transnitrosation reactions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Regulation of apoptosis by protein S-nitrosylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Impairment of the ubiquitin-proteasome system by protein aggregation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Modulation of neurodegeneration by molecular chaperones

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Acceleration of amyloid beta-peptide aggregation by physiological concentrations of calcium

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

The unfolded protein response: a stress signaling pathway critical for health and disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Redox modulation of the NMDA receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Hypoxia enhances S-nitrosylation-mediated NMDA receptor inhibition via a thiol oxygen sensor motif

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Screening for nitric oxide-dependent protein-protein interactions.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Nitrosative and oxidative stress links dysfunctional ubiquitination to Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Dopamine covalently modifies and functionally inactivates parkin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

The translocon: more than a hole in the ER membrane?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Setting the standards: quality control in the secretory pathway

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

The unfolded protein response: an intracellular signalling pathway with many surprising features

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Tripartite management of unfolded proteins in the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Catalysis of the oxidative folding of ribonuclease A by protein disulfide isomerase: dependence of the rate on the composition of the redox buffer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Site-directed mutagenesis of human protein disulphide isomerase: effect on the assembly, activity and endoplasmic reticulum retention of human prolyl 4-hydroxylase in Spodoptera frugiperda insect cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Protein aggregation after transient cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Misfolded proteins, endoplasmic reticulum stress and neurodegeneration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Up-regulation of protein-disulfide isomerase in response to hypoxia/brain ischemia and its protective effect against apoptotic cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Protein disulfide isomerase in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Chaperones increase association of tau protein with microtubules

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Ubiquitin, proteasomes, and the aging brain

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Cellular environment facilitates protein accumulation in aged rat hippocampus.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Glyceraldehyde-3-phosphate dehydrogenase: nuclear translocation participates in neuronal and nonneuronal cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Glyceraldehyde-3-phosphate dehydrogenase antisense oligodeoxynucleotides protect against cytosine arabinonucleoside-induced apoptosis in cultured cerebellar neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Mutant huntingtin: nuclear translocation and cytotoxicity mediated by GAPDH

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Nuclear targeting of mutant Huntingtin increases toxicity

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Overexpression and nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase in a transgenic mouse model of Huntington’s disease

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Neuroprotection by pharmacologic blockade of the GAPDH death cascade

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Glyceraldehyde-3-phosphate dehydrogenase, the putative target of the antiapoptotic compounds CGP 3466 and R-(-)-deprenyl

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

The chemical biology of clinically tolerated NMDA receptor antagonists

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Nitrate therapy may retard glaucomatous optic neuropathy, perhaps through modulation of glutamate receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Nitrosative stress in the ER: a new role for S-nitrosylation in neurodegenerative diseases.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402138

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4402138

1 reference

16 August 2017

1 reference

PubMed ID

17431424