A leukotriene C4 synthase inhibitor with the backbone of 5-(5-methylene-4-oxo-4,5-dihydrothiazol-2-ylamino) isophthalic acid. (Q36792066)

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23 February 2020

title

A leukotriene C4 synthase inhibitor with the backbone of 5-(5-methylene-4-oxo-4,5-dihydrothiazol-2-ylamino) isophthalic acid (English)

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23 February 2020

1

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23 February 2020

Makoto Taiji

7

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23 February 2020

author name string

Noriaki Okimoto

2

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23 February 2020

Yoshihide Kanaoka

3

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23 February 2020

Gentaro Morimoto

4

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23 February 2020

Yoko Ukita

5

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23 February 2020

Hiromichi Saino

6

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23 February 2020

Masashi Miyano

8

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23 February 2020

publication date

31 January 2013

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23 February 2020

published in

Journal of Biochemistry

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23 February 2020

volume

153

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23 February 2020

issue

5

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23 February 2020

page(s)

421-429

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The Catalytic Architecture of Leukotriene C4 Synthase with Two Arginine Residues

23 February 2020

cites work

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GPR17 regulates immune pulmonary inflammation induced by house dust mites

29 September 2017

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Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor

29 September 2017

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The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications

29 September 2017

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Endothelial cysteinyl leukotriene 2 receptor expression mediates myocardial ischemia-reperfusion injury.

29 September 2017

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Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis

29 September 2017

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Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase

29 September 2017

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Crystal structure and possible catalytic mechanism of microsomal prostaglandin E synthase type 2 (mPGES-2).

29 September 2017

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Cutting edge: agonistic effect of indomethacin on a prostaglandin D2 receptor, CRTH2

29 September 2017

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

29 September 2017

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Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4

29 September 2017

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Molecular cloning and expression of human leukotriene-C4 synthase

29 September 2017

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Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response

29 September 2017

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Leukotrienes and lipoxins: structures, biosynthesis, and biological effects

29 September 2017

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Zafirlukast for symptomatic mild-to-moderate asthma: a 13-week multicenter study. The Zafirlukast Trialists Group

29 September 2017

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Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs

27 June 2018

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Efficacy of leukotriene receptor antagonists and synthesis inhibitors in asthma.

27 June 2018

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Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice

5 September 2018

1 reference

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

5 September 2018

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Identification of dual cyclooxygenase-eicosanoid oxidoreductase inhibitors: NSAIDs that inhibit PG-LX reductase/LTB(4) dehydrogenase.

5 September 2018

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Attenuated zymosan-induced peritoneal vascular permeability and IgE-dependent passive cutaneous anaphylaxis in mice lacking leukotriene C4 synthase

5 September 2018

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Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities.

5 September 2018

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Local effects of synthetic leukotrienes (LTC4, LTD4, LTE4, and LTB4) in human skin

5 September 2018

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12 December 2020

Solubilization and partial purification of leukotriene C4 synthase from guinea-pig lung: a microsomal enzyme with high specificity towards 5,6-epoxide leukotriene A4

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12 December 2020

The effect of montelukast (MK-0476), a cysteinyl leukotriene receptor antagonist, on allergen-induced airway responses and sputum cell counts in asthma

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12 December 2020

Cysteinyl leukotrienes regulate Th2 cell-dependent pulmonary inflammation

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12 December 2020

Crystal Structure of Anti-Configuration of Indomethacin and Leukotriene B4 12-Hydroxydehydrogenase/15-Oxo-Prostaglandin 13-Reductase Complex Reveals the Structural Basis of Broad Spectrum Indomethacin Efficacy

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12 December 2020

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Leukotrienes are potent constrictors of human bronchi

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Identifiers

DOI

10.1093/JB/MVT007

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23 February 2020

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23 February 2020

PubMed publication ID

23378248

1 reference